Blar i NTNU Open på forfatter "Andreassen, Trygve"
-
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
Petrovic, Voin; Nepal, Anala; Olaisen, Camilla; Bachke, Siri; Hira, Jonathan; Søgaard, Caroline Krogh; Røst, Lisa Marie; Misund, Kristine; Andreassen, Trygve; Melø, Torun Margareta; Bartosova, Zdenka; Bruheim, Per; Otterlei, Marit (Journal article; Peer reviewed, 2018)The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract ... -
Associations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort study
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Peer reviewed; Journal article, 2022)Background: Our understanding of the mechanisms through which physical activity might benefit lipoprotein metabolism is inadequate. Here we characterise the continuous associations between physical activity of different ... -
Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Journal article; Peer reviewed, 2019)Background and aims: Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine ... -
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Biomarker discovery using NMR based metabolomics of tissue
Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ... -
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA
Frahm, Anne; Hill, Deborah Katherine; Katsikis, Sotirios; Andreassen, Trygve; Ardenkjær-Larsen, Jan Henrik; Bathen, Tone Frost; Moestue, Siver Andreas; Jensen, Pernille Rose; Lerche, Mathilde (Peer reviewed; Journal article, 2021)Hyperpolarized 13C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue ... -
Cross-sectional and prospective associations between aerobic fitness and lipoprotein particle profile in a cohort of Norwegian schoolchildren
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Peer reviewed; Journal article, 2021)Background and aims The associations between aerobic fitness and traditional measures of lipid metabolism in children are uncertain. We investigated whether higher levels of aerobic fitness benefit lipoprotein metabolism ... -
Effect of Repeated Freeze‒Thaw Cycles on NMR-Measured Lipoproteins and Metabolites in Biofluids
Wang, Feng; Debik, Julia; Andreassen, Trygve; Euceda, Leslie R.; Haukaas, Tonje Husby; Cannet, Claire; Schäfer, Hartmut; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)Metabolic profiling of biofluids by nuclear magnetic resonance (NMR) spectroscopy serves as an important tool in disease characterization, and its accuracy largely depends on the quality of samples. We aimed to explore ... -
Estrogen receptor α promotes breast cancer by reprogramming choline metabolism
Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui; Zhao, Chunyan; Haldosen, Lars-Arne; Cao, Yihai; Girnita, Leonard; Moestue, Siver Andreas; Dahlman-Wright, Karin (Journal article; Peer reviewed, 2016)Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated ... -
Identification of Metabolites from 2D 1H-13C HSQC NMR using Peak Correlation Plots
Öman, Tommy; Tessem, May-Britt; Bathen, Tone Frost; Bertilsson, Helena; Angelsen, Anders; Hedenström, Mattias; Andreassen, Trygve (Journal article; Peer reviewed, 2014)Background Identification of individual components in complex mixtures is an important and sometimes daunting task in several research areas like metabolomics and natural product studies. NMR spectroscopy is an excellent ... -
Identifying metabolic alterations in newly diagnosed small cell lung cancer patients
Pedersen, Shona; Hansen, Joachim Bavnhøj; Maltesen, Raluca Georgiana; Szejniuk, Weronica Maria; Andreassen, Trygve; Falkmer, Ursula; Kristensen, Søren Risom (Peer reviewed; Journal article, 2021)Background Small cell lung cancer (SCLC) is a malignant disease with poor prognosis. At the time of diagnosis most patients are already in a metastatic stage. Current diagnosis is based on imaging, histopathology, and ... -
Identifying possible biomarkers of lower urinary tract symptoms using metabolomics and partial least square regression
Hopland-Nechita, Florin Vasile; Andersen, John Roger; Rajalahti, Tarja; Andreassen, Trygve; Beisland, Christian (Peer reviewed; Journal article, 2023)Introduction The objective of this study was to explore potential novel biomarkers for moderate to severe lower urinary tract symptoms (LUTS) using a metabolomics-based approach, and statistical methods with significant ... -
Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study
Debik, Julia; Schäfer, Hartmut; Andreassen, Trygve; Wang, Feng; Fang, Fang; Cannet, Claire; Spraul, Manfred; Bathen, Tone Frost; Giskeødegård, Guro F. (Peer reviewed; Journal article, 2022)Background The aim of this study was to gain an increased understanding of the aetiology of breast cancer, by investigating possible associations between serum lipoprotein subfractions and metabolites and the long-term ... -
Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment
Giskeødegård, Guro F.; Madssen, Torfinn Støve; Sangermani, Matteo; Lundgren, Steinar; Wethal, Torgeir; Andreassen, Trygve; Reidunsdatter, Randi Johansen; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein ... -
New Methods for Preparationof Optically Active Unsaturated Amines
Andreassen, Trygve (Doktoravhandlinger ved NTNU, 1503-8181; 2009:12, Doctoral thesis, 2009) -
Perfusion system for studying dynamic metabolomics in rat brain slices exposed to oxygen–glucose deprivation using proton and phosphorus nuclear magnetic resonance
Molska, Alicja Anna; Hill, Deborah Katherine; Andreassen, Trygve; Widerøe, Marius (Peer reviewed; Journal article, 2022)The aim of the current study was to establish a controlled and reproducible model to study metabolic changes during oxygen–glucose deprivation (OGD) in rat brain using a nuclear magnetic resonance (NMR)-compatible perfusion ... -
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma
Abdollahi, Pegah; Vandsemb, Esten; Elsaadi, Samah; Røst, Lisa Marie; Yang, Rui; Hjort, Magnus Aassved; Andreassen, Trygve; Misund, Kristine; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Sponaas, Anne-Marit; Moestue, Siver Andreas; Bruheim, Per; Børset, Magne (Peer reviewed; Journal article, 2021)Cancer cells often depend on microenvironment signals from molecules such as cytokines for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic phosphatase, is highly expressed in multiple myeloma ... -
Serum NMR-Based Metabolomics Profiling Identifies Lipoprotein Subfraction Variables and Amino Acid Reshuffling in Myeloma Development and Progression
Pedersen, Shona; Mikkelstrup, Morten Faarbæk; Kristensen, Søren Risom; Anwardeen, Najeha Rizwana; Elrayess, Mohamed A.; Andreassen, Trygve (Peer reviewed; Journal article, 2023)Multiple myeloma (MM) is an incurable hematological cancer. It is preceded by monoclonal gammopathy of uncertain significance (MGUS)—an asymptomatic phase. It has been demonstrated that early detection increases the 5-year ... -
The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids
Giskeødegård, Guro F.; Andreassen, Trygve; Bertilsson, Helena; Tessem, May-Britt; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)Metabolomics analysis of biofluids is a feasible tool for disease characterization and monitoring due to its minimally invasive nature. To reduce unwanted variation in biobanks and clinical studies, it is important to ...