Browsing NTNU Open by Author "Zhang, Jianhai"
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Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: Insights from the promoter fusion studies
Sekurova, Olga N.; Zhang, Jianhai; Kristiansen, Kåre Andre; Zotchev, Sergey B (Peer reviewed; Journal article, 2016)Background Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES), respectively. Biosynthesis of Cml and Jad was shown ... -
Synthetic Biology of Antibiotic Production: Assembly and Re-factoring of Secondary Metabolite Biosynthesis Gene Clusters for Heterologous Expression in Genetically Engineered Bacterial Host
Zhang, Jianhai (Master thesis, 2014)The issues in new antibiotic discovery are pressing, because the frequent re-discovery of antibiotic scaffolds leads to few novel antibiotics discovered, besides, with the widespread use of antibacterial agents, multi-resistant ...