Blar i NTNU Open på forfatter "Bathen, Tone Frost"
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Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts
van der Kemp, Wybe J. M.; Grinde, Maria Tunset; Malvik, Jon Olav; van Laarhoven, Hanneke W. M.; Prompers, Jeanine J.; Klomp, Dennis W. J.; Burgering, Boudewijn; Bathen, Tone Frost; Moestue, Siver Andreas (Peer reviewed; Journal article, 2022)Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ... -
Metabolic response to everolimus in patient-derived triple negative breast cancer xenografts
Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre; Hatem, Rana; Botty, Rania; Bieche, Ivan; Marangoni, Elisabetta; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2017)Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the ... -
Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment
Madssen, Torfinn Støve; Thune, Inger; Flote, Vidar Gordon; Lundgren, Steinar; Bertheussen, Gro Falkener; Frydenberg, Hanne; Wist, Erik; Schlichting, Ellen; Schäfer, Hartmut; Fjøsne, Hans Erikssønn; Vettukattil, Muhammad Riyas; Lømo, Jon; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2018)Background Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Modeling the diffusion-weighted imaging signal for breast lesions in the b = 200 to 3000 s/mm 2 range: quality of fit and classification accuracy for different representations
Vidic, Igor; Egnell, Liv Elisabet; Jerome, Neil Peter; White, Nathan; Karunamuni, Roshan; Rakow-Penner, Rebecca; Dale, Anders M.; Bathen, Tone Frost; Goa, Pål Erik (Peer reviewed; Journal article, 2020)Purpose To evaluate different non‐Gaussian representations for the diffusion‐weighted imaging (DWI) signal in the b‐value range 200 to 3000 s/mm2 in benign and malignant breast lesions. Methods Forty‐three patients ... -
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity
Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2015)Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ... -
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity
Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2014-12-23)Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ... -
MRS-based metabolic profiling of cardiac and skeletal muscle from rats with heart failure, low intrinsic fitness, aging and exercise training
Shi, Mingshu (Doctoral theses at NTNU;2019:371, Doctoral thesis, 2019)Background: Heart failure is associated with reduced exercise capacity and impaired myocardial and skeletal muscle metabolism. Other factors, such as inborn genetic difference, aging, and exercise training, can also lead ... -
Multi-Level Molecular Characterisation of Prostate Cancer
Sandsmark, Elise (Doctoral theses at NTNU;2017:174, Doctoral thesis, 2017)Prostate cancer is the most common malignancy in Norwegian men, and represents a substantial health burden. The disease is heterogeneous, ranging from slow growing and indolent, to very aggressive and lethal. One of the ... -
Multi-parametric Diffusion Weighted Magnetic Resonance Imaging and Analysis in Breast Cancer
Vidić, Igor (Doctoral theses at NTNU;2019:203, Doctoral thesis, 2019)Accurate noninvasive diagnostic and subtyping procedures for cancer are very important. Diffusion-weighted imaging (DWI) reflects the microscopic cellular environment and is sensitive to tumor characteristics such as cell ... -
Multi-parametric diffusion-weighted magnetic resonance imaging and microstructural tissue properties in breast cancer
Egnell, Liv Elisabet (Doctoral theses at NTNU;2021:208, Doctoral thesis, 2021)Breast cancer is the most common cancer in women worldwide. Although breast cancer survival has improved in recent years, it remains a leading cause of cancer death in the female population worldwide. Breast cancer prognosis ... -
Multimodal Imaging-derived Biomarkers for Early Detection and Personalized Treatment of Breast Cancer
Andreassen, Maren Marie Sjaastad (Doctoral theses at NTNU;2022:304, Doctoral thesis, 2022)Accurate segmentation of cancer from surrounding healthy breast tissues in magnetic resonance imaging (MRI) without intravenous administration of contrast agents, is a question of wide interest. Current standard-of-care ... -
Multiparametric Characterization of Response to Anti-angiogenic Therapy Using USPIO Contrast-enhanced MRI in Combination with Dynamic Contrast-enhanced MRI
Kim, Jana; Kim, Eugene; Euceda, Leslie R.; Meyer, Dan E.; Langseth, Karina; Bathen, Tone Frost; Moestue, Siver Andreas; Huuse, Else Marie (Journal article, 2017)Background Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. Purpose To investigate the utility of the ultrasmall superparamagnetic iron oxide particles ... -
Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies
Krüger-Stokke, Brage; Bertilsson, Helena; Langørgen, Sverre; Sjøbakk, Torill Eidhammer; Bathen, Tone Frost; Selnæs, Kirsten Margrete (Peer reviewed; Journal article, 2021)Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ... -
NMR-based metabolomics of biofluids in cancer
Giskeødegård, Guro F.; Madssen, Torfinn Støve; Euceda, Leslie R.; Tessem, May-Britt; Moestue, Siver Andreas; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Metabolomics is the branch of “omics” technologies that involves high‐throughput identification and quantification of small‐molecule metabolites in the metabolome. NMR‐based spectroscopy of biofluids represents a potential ... -
NMR-Based Prostate Cancer Metabolomics
Euceda, Leslie R.; Andersen, Maria Karoline; Tessem, May-Britt; Moestue, Siver Andreas; Grinde, Maria Tunset; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model
Hill, Deborah Katherine; Heindl, Andreas; Zormpas-Petridis, Konstantinos; Collins, David J.; Euceda, Leslie R.; Rodrigues, Daniel; Moestue, Siver Andreas; Jamin, Yann; Koh, Dow-Mu; Yuan, Yinyin; Bathen, Tone Frost; Leach, Martin O; Blackledge, Matthew D. (Journal article; Peer reviewed, 2017)Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced ...