Blar i NTNU Open på forfatter "Bjørås, Magnar"
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Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ... -
Expanding the activity spectrum of antiviral agents
Ianevski, Aleksandr; Andersen, Petter I.; Merits, Andres; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2019) -
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles
Ravlo, Erlend; Sousa, Mirta; Andresen, Lise Lima; Holberg-Petersen, Mona; Klundby, Ingvild; Aas, Per Arne; Hagen, Lars; Erlandsen, Sten Even; Fossum, Janne; Ali, Zeeshan; Sharma, Anuvansh; Ottesen, Vegar; Bandyopadhyay, Sulalit; Bjørås, Magnar (Peer reviewed; Journal article, 2023)The year of 2020 was profoundly marked by a global pandemic caused by a strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19). ... -
Functional Impact of the Autophagy Lysosomal Pathway in Neurodevelopment and Neuroprotection
Aune, Ingvild Haugnes (Master thesis, 2021)Proteinet ubiquitin C-terminal hydrolase L1 (UCHL1) tilhører en familie av enzymer som hydrolyserer ubiquitin. Enzymet uttrykkes sterkt i hjernen og spesielt i nevroner, men dens primære funksjoner ukjent. Nylig identifiserte ... -
Functional Impact of the Ubiquitin Proteasomal System in Neurodevelopment and Neuroprotection
Oanæs, Celine (Master thesis, 2021)Ubiquitin er et lite molekyl som regulerer en mengde vitale molekylære prosesser i cellene våre ved å binde seg til diverse målproteiner. Ubiquitinaser kan fjerne dette molekylet fra substrat. Blant 100 ubiquitinaser som ... -
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Røsand, Øystein; Sarno, Antonio; Xing, Mengtan; Zhang, Qindong; Alirezaylavasani, Amin; Werner, Julia; Ji, Ping; Liabakk, Nina-Beate; Wang, Wei; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ... -
Generation of stem cell derived retinal organoids for the disease modeling and treatment of Retinitis Pigmentosa
Schjølberg, Jørn-Ove (Master thesis, 2021)The hereditary retinal disease Retinitis pigmentosa (RP) leads to loss of photoreceptor cells and is a significant cause of blindness, affecting over 2 million worldwide. This project focus on Retinitis pigmentosa type 11 ... -
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
Lobie, Tekle Airgecho; Woldeamanuel, Yimtubezinash; Asrat, Daniel; Beyene, Demissew Balcha; Bjørås, Magnar; Aseffa, Abraham (Peer reviewed; Journal article, 2020)Introduction Tuberculosis (TB) remains a major global public health problem and is the leading cause of death from a single bacterium, Mycobacterium tuberculosis (MTB) complex. The emergence and spread of drug-resistant ... -
Genetic interaction between the non-homologous end joining factors in mice and humans
Xing, Mengtan (Doctoral theses at NTNU;2019:117, Doctoral thesis, 2019) -
Glioblastom hos voksne
Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Peer reviewed; Journal article, 2023)lioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ... -
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Xu, Kaiqi; Chatzitakis, Athanasios Eleftherios; Risbakk, Sanne; Yang, Mingyi; Backe, Paul Hoff; Grandcolas, Mathieu; Bjørås, Magnar; Norby, Truls Eivind (Peer reviewed; Journal article, 2020)In this work, Co-based cocatalysts are electrodeposited on mesoporous Ta3N5 nanotubes. The electrodeposition time is varied and the optimized photoelectrode reaches a photocurrent density of 6.3 mA/cm2 at 1.23 V vs. SHE, ... -
Histone methylations define neural stem/progenitor cell subtypes in the mouse subventricular zone
Zhang, Zhichao; Manaf, Adeel; Li, Yanjiao; Pérez, Sonia Peña; Suganthan, Rajikala; Dahl, John Arne; Bjørås, Magnar; Klungland, Arne (Journal article; Peer reviewed, 2019)Neural stem/progenitor cells (NSPCs) persist in the mammalian brain throughout life and can be activated in response to the physiological and pathophysiological stimuli. Epigenetic reprogramming of NPSC represents a novel ... -
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Farooq, Amna; Grønmyr, Sindre; Omer, Ali Avan; Rognes, Torbjørn; Scheffler, Katja; Bjørås, Magnar; Wang, Junbai (Peer reviewed; Journal article, 2020)DNA methylation (5mC) and hydroxymethylation (5hmC) are chemical modifications of cytosine bases which play a crucial role in epigenetic gene regulation. However, cost, data complexity and unavailability of comprehensive ... -
Identification and Tracking of Antiviral Drug Combinations
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ... -
Identification of UCHL1 Binding Partners in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Motor Neurons
Sæther, Anna Maria (Master thesis, 2022)Proper protein regulation is crucial for cell function. Ubiquitin is a 76 amino acid (aa) protein functioning as a post translational modification and thereby playing a central role in protein regulation. Ubiquitin (Ub) ... -
Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data
Yang, Mingyi; Ali, Omer; Bjørås, Magnar; Wang, Junbai (Peer reviewed; Journal article, 2023)Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases. We propose a non-encoding SNVs analysis tool bpb3, BayesPI-BAR ... -
The impact of the DNA glycosylase NEIL3 on neural coding of spatial learning and memory
Kunath, Nicolas (Doctoral theses at NTNU;2021:1, Doctoral thesis, 2021) -
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Bosshard, Matthias; Aprigliano, Rossana; Gattiker, Cristina; Palibrk, Vuk; Markkanen, Enni; Backe, Paul Hoff; Pellegrino, Stefania; Raymond, F. Lucy; Froyen, Guy; Altmeyer, Matthias; Bjørås, Magnar; Dianov, Grigory L.; van Loon, Barbara (Journal article; Peer reviewed, 2017)Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity ... -
In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell
Xu, Kaiqi; Chatzitakis, Athanasios Eleftherios; Backe, Paul Hoff; Ruan, Qiushi; Junwang, Tang; Rise, Frode; Bjørås, Magnar; Norby, Truls Eivind (Peer reviewed; Journal article, 2021)Mimicking natural photosynthesis by direct photoelectrochemical (PEC) reduction of CO2 to chemicals and fuels requires complex cell assemblies with limitations in selectivity, efficiency, cost, and stability. Here, we ... -
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Askeland, Georgina; Dosoudilova, Zaneta; Rodinova, Marie; Klempir, Jiri; Liskova, Irena; Kusnierczyk, Anna; Bjørås, Magnar; Nesse, Gaute; Klungland, Arne; Hansikova, Hana; Eide, Lars (Journal article; Peer reviewed, 2018)Huntington’s disease (HD) is a progressive neurodegenerative disorder primarily affecting the basal ganglia and is caused by expanded CAG repeats in the huntingtin gene. Except for CAG sizing, mitochondrial and nuclear DNA ...