Blar i NTNU Open på forfatter "Klepstad, Pål"
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Continuous subcutaneous infusion for pain control in dying patients: experiences from a tertiary palliative care center
Fürst, Per; Lundström, Staffan; Klepstad, Pål; Strang, Peter (Peer reviewed; Journal article, 2020)Background Continuous subcutaneous infusion (CSCI) via ambulatory infusion pump (AIP) is a valuable method of pain control in palliative care. When using CSCI, low-dose methadone as add-on to other opioids might be an ... -
Corticosteroids for Cancer Pain
Paulsen, Ørnulf (Doctoral theses at NTNU;2017:117, Doctoral thesis, 2017) -
Desflurane consumption with automated vapour control systems in two different anaesthesia machines. A randomized controlled study
Mostad, Dagmar; Klepstad, Pål; Follestad, Turid; Pleym, Hilde (Peer reviewed; Journal article, 2021)Background: In general anaesthesia practice a fresh gas flow (FGF) of ≥0.5 L/min is usually applied. Automated gas delivery devices are developed to reduce volatile anaesthetic consumption by limiting gas flow. This study ... -
Developing quality indicators for physician-staffed emergency medical services: a consensus process
Haugland, Helge Nystad; Rehn, Marius; Klepstad, Pål; Krüger, Andreas Jørstad (Journal article; Peer reviewed, 2017)Background There is increasing interest for quality measurement in health care services; pre-hospital emergency medical services (EMS) included. However, attempts of measuring the quality of physician-staffed EMS (P-EMS) ... -
Diagnostic and antimicrobial aspects of ventilator-associated pneumonia in an intensive care, low antimicrobial resistance prevalence setting
Gjønnes, Geir Tormod (Master thesis, 2021)Introduksjon. Håndteringen av ventilator-assosiert pneumoni (VAP) representerer dilemmaet mellom å sikre dekning av potensielt multiresistente patogener på den ene siden og på den andre siden redusere forbruket av bredspektret ... -
Effectiveness of Opioid Switching in Advanced Cancer Pain: A Prospective Observational Cohort Study
Wong, Aaron K.; Somogyi, Andrew A.; Rubio, Justin; Pham, Tien Dung; Le, Brian; Klepstad, Pål; Philip, Jennifer (Peer reviewed; Journal article, 2023)Opioid switching is a common practice of substituting one opioid for another to improve analgesia or adverse effects; however, it has limited evidence. This study aimed to examine the effectiveness of opioid switching in ... -
Emergency Palliative Cancer Care: Dexmedetomidine Treatment Experiences—A Retrospective Brief Report on Nine Consecutive Cases
Løhre, Erik Torbjørn; Svedahl, Augstein; Jakobsen, Gunnhild; Solheim, Tora S; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)Introduction Dexmedetomidine, an alpha-2 adrenergic receptor agonist with potential opioid sparing properties, is utilized in palliative medicine, but the knowledge base for this practice is limited. We describe concomitant ... -
An exploratory study examining the relationship between performance status and systemic inflammation frameworks and cytokine profiles in patients with advanced cancer
Dolan, Ross D.; Laird, Barry J.A.; Klepstad, Pål; Kaasa, Stein; Horgan, Paul G.; Paulsen, Ørnulf; McMillan, Donald C. (Peer reviewed; Journal article, 2019)The role of cytokines in the systemic inflammatory response (SIR) is now well established. This is in keeping with the role of the SIR in tumorigenesis, malignant spread, and the development of cachexia. However, the ... -
Feasibility of Pre-Hospital Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-Traumatic Out-of-Hospital Cardiac Arrest
Brede, Jostein Rødseth; Lafrenz, Thomas; Klepstad, Pål; Skjærseth, Eivinn Årdal; Nordseth, Trond; Søvik, Edmund; Krüger, Andreas (Journal article; Peer reviewed, 2019)Background Few patients survive after out‐of‐hospital cardiac arrest and any measure that improve circulation during cardiopulmonary resuscitation is beneficial. Animal studies support that resuscitative endovascular ... -
Frailty and survival in elderly intensive care patients in Norway
Andersen, Finn Husøy; Haaland, Øystein Ariansen; Klepstad, Pål; Flaatten, Hans (Journal article; Peer reviewed, 2021)Background Today, 10%-15% of Norwegian intensive care patients are ≥80 years. This proportion will increase significantly over the next 20 years, but it is unlikely that resources for intensive care increase correspondingly. ... -
From "breakthrough" to "episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations
Løhre, Erik T; Klepstad, Pål; Bennett, Michael I.; Brunelli, Cinzia; Caraceni, Augusto; Fainsinger, Robin L.; Knudsen, Anne Kari; Mercadante, Sebastiano; Sjøgren, Per; Kaasa, Stein (Journal article; Peer reviewed, 2016)Context Cancer pain can appear with spikes of higher intensity. Breakthrough cancer pain (BTCP) is the most common term for the transient exacerbations of pain, but the ability of the nomenclature to capture relevant ... -
Genetic and Non-genetic Factors Associated WithConstipation in Cancer Patients Receiving Opioids
Laugsand, Eivor Alette; Skorpen, Frank; Kaasa, Stein; Sabatowski, Rainer; Strasser, Florian; Fayers, Peter; Klepstad, Pål (Journal article; Peer reviewed, 2015)Objectives: To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors. Methods: Cancer patients receiving ... -
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer
Kurita, Geana Paula; Ekholm, Ola; Kaasa, Stein; Klepstad, Pål; Skorpen, Frank; Sjøgren, Per (Peer reviewed; Journal article, 2016)Background and purpose The effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to ... -
Health care providers underestimate symptom intensities of cancer patients: A multicenter European study
Laugsand, Eivor Alette; Sprangers, Mirjam A. G.; Bjordal, Kristin; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2010)Background: Many patients with advanced cancer depend upon health care providers for symptom assessment. The extent of agreement between patient and provider symptom assessments and the association of agreement with ... -
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ... -
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients
Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tomasso Giovanni (Peer reviewed; Journal article, 2020)Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ... -
Improper monitoring and deviations from physiologic treatment goals in patients with brain injury in the early phases of emergency care.
Andersen, Siri Kojen; Hustveit, Ragnhild; Frøland, Erlend; Uleberg, Oddvar; Kruger, Andreas; Klepstad, Pål; Nordseth, Trond (Peer reviewed; Journal article, 2020)Severe traumatic brain injury (TBI), out-of-hospital cardiac arrest (OHCA) and intracerebral- and subarachnoid hemorrhage (ICH/SAH) are conditions associated with high mortality and morbidity. The aim of this study was to ... -
Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia; Rossi, Romina; Garcia-Alonso, Elena; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2022)Context Inflammation is proposed to influence tumor response in radiotherapy (RT). Clinical studies to investigate the relationship between inflammatory markers and RT response is warranted to understand the variable RT ... -
The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
Langeland, Halvor Johannes Breivik; Damås, Jan Kristian; Mollnes, Tom Eirik; Ludviksen, Judith K; Ueland, Thor; Michelsen, Annika Elisabet; Løberg, Magnus; Bergum, Daniel; Nordseth, Trond; Skjærvold, Nils Kristian; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background: Whole body ischemia and reperfusion injury after cardiac arrest leads to the massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous studies on the inflammatory effect on ... -
Influenza and associated co-infections in critically ill immunosuppressed patients
Martin-Loeches, Ignacio; Lemiale, Virginie; Geoghegan, Pierce; McMahon, Mary Aisling; Pickkers, Peter; Soares, Marcio; Perner, Anders; Meyhoff, Tine Sylvest; Bukan, Ramin Brandt; Rello, Jordi; Bauer, Philippe R.; van de Louw, Andry; Taccone, Fabio Silvio; Salluh, Jorge; Hemelaar, Pleun; Schellongowski, Peter; Rusinova, Katerina; Terzi, Nicolas; Mehta, Sangeeta; Antonelli, Massimo; Kouatchet, Achille; Klepstad, Pål; Valkonen, Miia; Landburg, Precious Pearl; Barratt-Due, Andreas; Bruneel, Fabrice; Pène, Frédéric; Metaxa, Victoria; Moreau, Anne Sophie; Souppart, Virginie; Burghi, Gaston; Girault, Christophe; Silva, Ulysses V.A.; Montini, Luca; Barbier, Francois; Nielsen, Lene B.; Gaborit, Benjamin; Mokart, Djamel; Chevret, Sylvie; Azoulay, Elie (Journal article; Peer reviewed, 2019)Background It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure. Methods Preplanned ...