Blar i NTNU Open på forfatter "Klepstad, Pål"
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Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
Barratt, Daniel T.; Klepstad, Pål; Dale, Ola; Kaasa, Stein; Somogyi, Andrew A. (Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
Intensive care for the very old
Andersen, Finn Husøy (Doctoral theses at NTNU;2017:166, Doctoral thesis, 2017)Introduction: The older population is expected to increase markedly during the next decades. The life expectancy of older patients is increasing, but the prevalence of conditions that require ICU treatment is also growing. ... -
Interventional techniques to management of cancer-related pain: Clinical and critical aspects
Kurita, Geana Paula; Sjøgren, Per Johan E; Klepstad, Pål; Mercadante, Sebastiano (Journal article; Peer reviewed, 2019)Interventional techniques to manage cancer-related pain may be efficient treatment modalities in patients unresponsive or unable to tolerate systemic opioids. However, indication and selection of the right technique demand ... -
Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study
Thronæs, Morten; Løhre, Erik T; Kvikstad, Anne; Brenne, Elisabeth; Norvaag, Robin; Aalberg, Kathrine Otelie; Moen, Martine Kjølberg; Jakobsen, Gunnhild; Klepstad, Pål; Solberg, Arne; Solheim, Tora S (Journal article; Peer reviewed, 2021)Purpose To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services. Methods All ... -
Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study
Farbu, Bjørn Hoftun; Langeland, Halvor; Ueland, Thor; Michelsen, Annika Elisabet; Krüger, Andreas Jørstad; Klepstad, Pål; Nordseth, Trond (Peer reviewed; Journal article, 2023)Background The impact of intestinal injury in cardiac arrest is not established. The first aim of this study was to assess associations between clinical characteristics in out-of-hospital cardiac arrest (OHCA) and a ... -
Is there a genetic cause of appetite loss? - An explorative study in 1853 cancer patients
Solheim, Tora Skeidsvoll; Fayers, Peter; Fladvad, Torill; Tan, Ben; Skorpen, Frank; Fearon, Kenneth C.; Baracos, Vickie; Klepstad, Pål; Strasser, Florian; Kaasa, Stein (Journal article; Peer reviewed, 2012)Background Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi‐factorial syndrome defined by a ... -
«Lindrende behandling i livets sluttfase - dokumentert praksis på en intensivavdeling» - Et kvalitetssikringsprosjekt med retrospektiv journalgjennomgang
Fjøsne, Kari (Master thesis, 2022)Bakgrunn Helsedirektoratet har utgitt nasjonale faglige råd for lindrende behandling i livets sluttfase. Mange intensivpasienter i livets sluttfase har stor symptombyrde og for å sikre at lindrende behandling er av god ... -
Long-term survival and quality of life after intensive care for patients 80 years of age or older
Andersen, Finn H; Flaatten, Hans; Klepstad, Pål; Romild, Ulla Kristina; Kvåle, Reidar (Journal article; Peer reviewed, 2015)Background Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. Methods We retrospectively analyzed survival of ... -
Morphine for cancer pain
Klepstad, Pål (Dissertations at the Faculty of Medicine, 0805-7680; 209, Doctoral thesis, 2002)The objectives of the present study were: I. To assess the effect from start of morphine treatment to cancer pain patients in respect to time needed for dose-finding, dose needed for pain control and adverse symptoms. II. ... -
Norwegian trauma care: a national cross-sectionalsurvey of all hospitals involved in the managementof major trauma patients
Uleberg, Oddvar; Vinjevoll, Ole-Petter; Kristiansen, Thomas; Klepstad, Pål (Journal article; Peer reviewed, 2014)Background: Approximately 10% of the Norwegian population is injured every year, with injuries ranging from minor injuries treated by general practitioners to major and complex injuries requiring specialist in-hospital ... -
Pain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Study
Løhre, Erik Torbjørn; Hjermstad, Marianne Jensen; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2018)Introduction Different definitions of breakthrough pain (BTP) influence the observed BTP prevalence. This study examined BTP prevalence variability due to use of different cutoffs for controlled background pain, different ... -
Pain management index (PMI)-does it reflect cancer patients? wish for focus on pain?
Thronæs, Morten; Balstad, Trude Rakel; Brunelli, Cinzia; Løhre, Erik Torbjørn; Klepstad, Pål; Vagnildhaug, Ola Magne; Kaasa, Stein; Knudsen, Anne Kari; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background The pain management index (PMI) was developed to combine information about the prescribed analgesics and the self-reported pain intensity in order to assess physicians’ response to patients’ pain. However, ... -
Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning
Estrup Olesen, Anne; Grønlund, Debbie; Gram, Mikkel; Skorpen, Frank; Drewes, Asbjørn Mohr; Klepstad, Pål (Journal article; Peer reviewed, 2018)Objective Use of opioids for pain management has increased over the past decade; however, inadequate analgesic response is common. Genetic variability may be related to opioid efficacy, but due to the many possible ... -
Quality in physician-staffed pre-hospital emergency medical services– developing a method for continuous quality estimation
Haugland, Helge (Doctoral theses at NTNU;2020:89, Doctoral thesis, 2020) -
Quality measurement in physician-staffed emergency medical services: a systematic literature review
Haugland, Helge Nystad; Uleberg, Oddvar; Klepstad, Pål; Krüger, Andreas; Rehn, Marius (Peer reviewed; Journal article, 2018)Purpose Quality measurement of physician-staffed emergency medical services (P-EMS) is necessary to improve service quality. Knowledge and consensus on this topic are scarce, making quality measurement of P-EMS a high-priority ... -
REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial
Brede, Jostein Rødseth; Skulberg, Arne Kristian; Rehn, Marius; Thorsen, Kjetil; Klepstad, Pål; Tylleskär, Ida; Farbu, Bjørn; Dale, Jostein; Nordseth, Trond; Wiseth, Rune; Krüger, Andreas Jørstad (Journal article; Peer reviewed, 2021)Background: Survival after out-of-hospital cardiac arrest (OHCA) is poor and dependent on high-quality cardiopulmonary resuscitation. Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be advantageous ... -
Resuscitative endovascular balloon occlusion of the aorta (REBOA) in non-traumatic out-of-hospital cardiac arrest: Evaluation of an educational programme
Brede, Jostein Rødseth; Lafrenz, Thomas; Krüger, Andreas; SØVIK, EDMUND; Steffensen, Torjus Lines; Kriesi, Carlo; Steinert, Martin; Klepstad, Pål (Journal article; Peer reviewed, 2019)Background Out-of-hospital cardiac arrest (OHCA) is a critical incident with a high mortality rate. Augmentation of the circulation during cardiopulmonary resuscitation (CPR) might be beneficial. Use of resuscitative ... -
Resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest
Brede, Jostein Rødseth (Doctoral theses at NTNU;2022:55, Doctoral thesis, 2022) -
Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: An observational study Cancer palliative care
Lee, Yong Joo; Suh, Sang-Yeon; Song, Junghan; Lee, Sanghee Shiny; Seo, Ah-Ram; Ahn, Hong-Yup; Lee, Myung Ah; Kim, Chul-Min; Klepstad, Pål (Peer reviewed; Journal article, 2015)Background:The feasibility and clinical implication of drug monitoring of morphine, morphine-6-glucuronide (M6G)and morphine-3-glucuronide (M3G) need further investigation. This study aimed to determine what predicts ... -
Short-term Effects of Endotracheal Suctioning in Post-Cardiac Arrest Patients
Eggen, Idunn Banschbach; Brønstad, Gunhild (Master thesis, 2020)Introduksjon: Endotrakeal suging er en intensivprosedyre som er nødvendig for å opprettholde åpne luftveier, men som ofte kan føre til uheldige fysiologiske effekter. Vi studerte insidensen av og risikofaktorer for slike ...