Browsing NTNU Open by Author "Anthonsen, Marit Walbye"
Now showing items 1-20 of 21
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Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection
Loevenich, Simon; Malmo, Jostein; Liberg, Ann Magritt; Sherstova, Tatyana; Li, Youxian; Rian, Kristin; Johnsen, Ingvild Bjellmo; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2019)Human metapneumovirus (HMPV) may cause severe respiratory disease. The early innate immune response to viruses like HMPV is characterized by induction of antiviral interferons (IFNs) and proinflammatory immune mediators ... -
Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection
Li, Youxian; Lund, Cecilie; Nervik, Ida; Loevenich, Simon; Døllner, Henrik; Anthonsen, Marit Walbye; Johnsen, Ingvild Bjellmo (Journal article; Peer reviewed, 2018)Thymic stromal lymphopoietin (TSLP) is associated with several allergic diseases including asthma. Two isoforms of TSLP exist in humans, a long form (lfTSLP) and a short form (sfTSLP), displaying distinct immunological ... -
Common nodes of virus–host interaction revealed through an integrated network analysis
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Cytokine profiles in human metapneumovirus infected children: Identification of genes involved in the antiviral response and pathogenesis
Malmo, Jostein; Moe, Nina; Krokstad, Sidsel; Ryan, Liv; Loevenich, Simon; Johnsen, Ingvild Bjellmo; Espevik, Terje; Nordbø, Svein Arne; Døllner, Henrik; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2016)Human metapneumovirus (hMPV) causes severe airway infection in children that may be caused by an unfavorable immune response. The nature of the innate immune response to hMPV in naturally occurring infections in children ... -
Deciphering the pathomolecular mechanisms underlying thoracic aortic aneurysm formation in syndromic patients
Pulli, Hanna Riina Elina (Master thesis, 2022)A thoracic aortic aneurysm (TAA) is local dilatation that occurs in the major blood vessel from which blood flows to the aorta. In the worst case, weakened dilation can lead to rupture. Clinical decision making for the ... -
Exploring cell death mechanisms upon infection with respiratory syncytial virus
Trøen, Synne-Louise (Master thesis, 2024)Respiratorisk syncytialt virus (RSV) utgjør en betydelig helseutfordring, og rammer spesielt eldre, immunkompromitterte individer og små barn. Akutt lungeskade indusert av virus er knyttet til celledød en frigjøring av ... -
Exploring endoplasmic reticulum stress responses and senescence upon infection with respiratory syncytial virus
Grønli, Elisabeth (Master thesis, 2024)Respiratorisk syncytialt-virus (RS-virus) er et av de vanligste årsakene til akutt respiratorisk infeksjon hos nyfødte og infeksjonen påvirker cellulære mekanismer i vertscellene. Tidligere studier har vist at RS-virus kan ... -
Exploring the cGAS-STING axis and DNA damage after infection with respiratory syncytial virus
Frossdal, Fredrik Simonsen (Master thesis, 2024)Cyclic GMP-AMP synthase (cGAS) er primært kjent som en cytosolisk DNA-sensor, som aktiverer medfødte immunresponser gjennom stimulator of interferon genes (STING). cGAS har nylig også blitt funnet lokalisert til kjernen i ... -
Exploring the cGAS-STING immune pathway in infection with respiratory syncytial virus
Damlien, Elise (Master thesis, 2023)Respiratorisk syncytialvirus (RSV) er en av hovedårsakene til akutt luftveisinfeksjon. Den sykliske GMP-AMP-syntase (cGAS) - stimulator av interferon-gener (STING)-signalveien gjenkjenner DNA-virus for å stimulere interferon ... -
Exploring the hepatitis C virus encoded protease NS3/4A in relation to Autophagy
Leirvik, Gunnhild Vatne (Master thesis, 2011)Autophagy is an evolutionarily conserved intracellular bulk degradation system essential for the cell homeostasis. In addition, autophagy is emerging as a central component in viral host defense. Many pathogens have evolved ... -
Genomics of Staphylococcus aureus and Enterococcus faecalis isolated from the ocular surface of dry eye disease sufferers
Amer, Ahmed M. (Master thesis, 2024)Tørre øyne er en utbredt okulær tilstand som rammer millioner av mennesker verden over. Ubehag, betennelse og smerte er fremtredende symptomer på sykdommen og påvirker pasientens livskvalitet. Nyere forskning viser at ... -
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M
Hansen, Marianne Dore; Johnsen, Ingvild Bjellmo; Stiberg, Kim Andre Ha; Sherstova, Tatyana; Wakita, Takaji; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Meurs, Eliane F.; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2017)Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral replication complexes by remodeling host intracellular membranes to a membranous web. The precise composition of these replication complexes ... -
Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens
Loevenich, Simon; Montaldo, Nicola Pietro; Wickenhagen, Arthur; Sherstova, Tatyana; van Loon, Barbara; Boyartchuk, Victor; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2023) -
Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN
Loevenich, Simon; Spahn, Alix Saskia; Rian, Kristin; Boyartchuk, Victor; Anthonsen, Marit Walbye (Peer reviewed; Journal article, 2021)The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory ... -
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network
van den Hoogen, Bernadette; Santoni, Angela; Sciume, Giuseppe; Bowie, Andrew; O'Farrelly, Cliona; O'Neill, Luke; Anthonsen, Marit Walbye; Pardali, Katerina; Young, Simon; Bergthaler, Andreas; Manel, Nicolas; Zahn, Roland; Kikkert, Marjolein; Snijder, Eric J.; van Kuppeveld, Frank; Fouchier, Ron A. M.; Hiscott, John B. (Peer reviewed; Journal article, 2020)The past century has witnessed major advances in the control of many infectious diseases, yet outbreaks and epidemics caused by (re-) emerging RNA viruses continue to pose a global threat to human health. As illustrated ... -
The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the golgi apparatus during hepatitis C virus infection
Daussy, Coralie F.; Monard, Sarah C.; Guy, Coralie; Muñoz-González, Sara; Chazal, Maxime; Anthonsen, Marit Walbye; Jouvenet, Nolwenn; Henry, Thomas; Dreux, Marlène; Meurs, Eliane F.; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)Hepatitis C virus (HCV) infection triggers Golgi fragmentation through the Golgi-resident protein immunity-related GTPase M (IRGM). Here, we report the roles of NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) and ... -
Innate immune responses to human metapneumovirus - Exploring cellular models and molecular mechanisms of interferon regulation and action
Loevenich, Simon (Doctoral theses at NTNU;2020:101, Doctoral thesis, 2020)Luftveisinfeksjoner forårsaket av virus og bakterier er et betydelig folkehelseproblem. Særlig for barn, gamle mennesker og personer med lungesykdom eller svekket immunsystem kan disse infeksjonene være livstruende. For ... -
Interactions of Single-stranded RNA Viruses With Autophagy Components and Innate Immune Signaling
Stiberg, Kim André Ha (Doctoral thesis at NTNU;2016:206, Doctoral thesis, 2016)NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET DET MEDISINSKE FAKULTET Vekselvirkninger mellom enkelttrådete RNA-virus, autofagikomponenter og det medfødte immunforsvaret I dette arbeidet har vi sett på samspillet ... -
LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
Oestvang, Janne; Anthonsen, Marit Walbye; Johansen, Berit (Journal article; Peer reviewed, 2011)Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine ... -
Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine
Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon; Koit, Sandra; Tenson, Tanel; Hukkanen, Veijo; Anthonsen, Marit Walbye; Bjørås, Magnar; Evander, Magnus; Windisch, Marc P; Zusinaite, Eva; Kainov, Denis (Peer reviewed; Journal article, 2019)Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral ...