Blar i NTNU Open på forfatter "Davies, Catharina de Lange"
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Method development and automated analysis of ultrasound images of phase-shift bubbles.
Sulheim, Snorre (Master thesis, 2015)Ultrasound mediated drug delivery is an important tool in the fight against cancer. A new concept called Acoustic Cluster Therapy (ACT ) is under development, and two pilot imaging studies have been performed on prostate cancer ... -
Modeling and data assimilation for improved ultrasound measurement of blood velocity fields
Grønli, Thomas (Master thesis, 2017)Cardiovascular disease is the leading cause of death worldwide, and echocardiography stands as a fundamental tool in assessing congenital or developed heart failure. A cornerstone of echocardiography is the ability to ... -
Modeling nanoparticle transport in tumors with a pore network model
Liavåg, Stig-Martin (Master thesis, 2019)Ei mogleg tilnærming i kreftbehandling er å innkapsle cytotoksiske medisinar i nanopartiklar for å auke spesifisiteten til medisinane samtidig som systemisk tokisitet blir redusert. Fokusert ultralyd i kombinasjon med ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Multi-timescale microscopy methods for the characterization of fluorescently-labeled microbubbles for ultrasound-triggered drug release
Nawijn, Charlotte; Segers, Tim; Lajoinie, Guillaume; Mørch, Ýrr Asbjørg; Berg, Sigrid; Snipstad, Sofie; Davies, Catharina de Lange; Versluis, Michel (Peer reviewed; Journal article, 2021)Microbubble contrast agents hold great promise for drug delivery applications with ultrasound. Encapsulating drugs in nanoparticles reduces systemic toxicity and increases circulation time of the drugs. In a novel approach ... -
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound
Einen, Caroline; Price, Sebastian Everard Nordby; Ulvik, Kim; Gjennestad, Magnus Aashammer; Hansen, Rune; Kjelstrup, Signe; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate ... -
Nanoparticles, ultrasound and microbubble mediated drug delivery in cancer models
Fagerland, Stein-Martin Tilrum (Doctoral theses at NTNU;2020:97, Doctoral thesis, 2020)Denne avhandlingen omhandler forbedring av kreftbehandling gjennom økt levering av cellegift til kreftvev ved bruk av nanopartikler eller ultralyd kombinert med mikrobobler. Ved å kapsle cellegift inn i nanopartikler kan ... -
Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study
Kumar, Rajesh; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Isaksen, vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2015)Biomolecular changes in the cartilage matrix during the early stage of osteoarthritis may be detected by Raman spectroscopy. The objective of this investigation was to determine vibrational spectral differences among ... -
Optimization and verification of dosimetric robustness of VMAT dose-plans
Hægeland, Camilla (Master thesis, 2016)Radiation therapy has for several years played an important role in the curative management of patients with early stage disease and also in the palliation of symptoms associated with advanced or metastatic disease. Organs ... -
Optimization, Cellular Uptake and Cytotoxicity of Lipid Nanoparticles
Jorstad, Ida Sofie (Master thesis, 2016)Chemotherapy can potentially be greatly improved by using nanoparticles as drug carriers to deliver chemotherapeutic drugs specifically to cancer cells. Lipid nanoparticles can encapsulate hydrophobic drugs that have low ... -
Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability
Poon, Charissa; Mühlenpfordt, Melina; Olsman, Marieke; Kotopoulis, Spiros; Davies, Catharina de Lange; Hynynen, Kullervo (Peer reviewed; Journal article, 2022)The blood-brain barrier (BBB) is a key challenge for the successful delivery of drugs to the brain. Ultrasound exposure in the presence of microbubbles has emerged as an effective method to transiently and locally increase ... -
Robot Control in Image-Guided Intervention
Østvik, Andreas (Master thesis, 2016)Introducing autonomous robot systems in clinical medicine is deemed extremely challenging due to the complex scene involved and variations between patients. The majority of commercialized systems are controlled directly ... -
Simulation of nonlinear wave propagation in ultrasound.
Seljåsen, Håkon (Master thesis, 2014)Nonlinear wave propagation has, for the last couple of decades, become an increasingly more important tool in medical ultrasound imaging. Creating ultrasound images from echoes in the second harmonic frequency band provides ... -
Solid Stress and Nanoparticle Microdistribution in Xenografts: Effects of Ultrasound and Microbubble Cavitation
Hanson, Ingunn (Master thesis, 2018)A drug delivery system (DDS) was characterized for two different xenografts in mice: OHS and PC3. Nanoparticles (NP) encapsulating fluorescent model drugs were used as stabilizing shells around gas microbubbles (MB), and ... -
Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ... -
Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation
Snipstad, Sofie; Sulheim, Einar; Davies, Catharina de Lange; Moonen, Chrit; Storm, Gert; Kiessling, Fabian; Schmid, Ruth; Lammers, Twan (Journal article; Peer reviewed, 2018)Introduction: Ultrasound in combination with microbubbles can make cells and tissues more accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we introduce the term ‘sonopermeation’, ... -
Sonopermeation with nanoparticle-stabilized microbubbles reduces solid stress and improves nanomedicine delivery to tumors
Sulheim, Einar; Hanson, Ingunn; Snipstad, Sofie; Vikedal, Krister; Mørch, Ýrr Asbjørg; Boucher, Yves; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Drug delivery to tumors is challenging due to biological barriers obstructing effective delivery. Sonopermeation with ultrasound and microbubbles has been shown to improve therapeutic effect of many classes of drugs, but ... -
Sonoporation using nanoparticle-loaded microbubbles increases cellular uptake of nanoparticles compared to co-incubation of nanoparticles and microbubbles
Snipstad, Sofie; Hanstad, Sigurd; Bjørkøy, Astrid; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Therapeutic agents can benefit from encapsulation in nanoparticles, due to improved pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake and sustained release. Microbubbles in ... -
Spheroid Coculture of Human Gingiva-Derived Progenitor Cells With Endothelial Cells in Modified Platelet Lysate Hydrogels
Shanbhag, Siddharth; Elsebahy, Ahmad Rashad; Helgeland Nymark, Ellen; Suliman, Salwa; Davies, Catharina de Lange; Stavropoulos, Andreas; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Elnour (Peer reviewed; Journal article, 2021)Cell coculture strategies can promote angiogenesis within tissue engineering constructs. This study aimed to test the angiogenic potential of human umbilical vein endothelial cells (HUVEC) cocultured with gingiva-derived ... -
Study of the chicken chorioallantoic membrane (CAM) as an in vivo-model for ultrasound-mediated delivery of drugs using nanoparticle-stabilized- and standard ultrasound microbubbles
Salomonsen, May Lise (Master thesis, 2018)The chick chorioallantoic membrane (CAM) model has been widely used in the fields of biology and medicine, and it provides a good in vivo model for studying vascularisation properties of a developing chicken embryo. The ...