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dc.contributor.authorUcar, Seniz
dc.date.accessioned2017-09-08T08:59:37Z
dc.date.available2017-09-08T08:59:37Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/11250/2453707
dc.description.abstractNature produces a variety of highly functional composite structures by the combination of organic and inorganic constituents and these composites stand as a central source of interest and inspiration for tissue engineering applications. In order to highlight the controlling mechanisms used by nature and employ these strategies to design efficient synthetic materials for clinical use, it is vital to study the interactions between organic and inorganic components. In this context, the purpose of this work has been to investigate the effects of alginate additives on different stages of calcium phosphate mineralization. The motivation for this study was founded on a model system composed of alginate hydrogel with calcium phosphate mineral content which has been comprehensively explored in our group as a potential scaffold material for bone tissue engineering applications. The intermolecular interactions of alginate with calcium phosphate minerals were investigated by using compositional variations of alginate in terms of block structure and molecular weight so that the operative interactions between the molecules and minerals could be assessed. The mineralization processes and regulatory roles of alginate additives were systematically studied by use of the complementary experimental techniques that combine monitoring of solution chemistry with material characterization. Detailed studies were conducted on brushite crystallization where the growth rates were determined quantitatively and the effects of alginate additives on growth mechanisms were investigated. By coupling of growth data and spontaneous precipitation experiments information on nucleation kinetics were also deduced. The kinetics of brushite transformation to hydroxyapatite in the presence of alginate was investigated in detail and the rate-determining reaction mechanisms were determined. Hydroxyapatite formation was also investigated via the amorphous calcium phosphate precursor. The course of reaction was studied in detail where the steps of hydroxyapatite formation and the operating mechanisms were discussed as well as the effects of varying alginate additives on these processes. The findings in this study may improve the understanding of the roles of additives with similar structure and functionality during mineralization such as other polysaccharides that are known to have regulatory roles in biomineral formation and contribute to the design of better controlled composite model structures.nb_NO
dc.language.isoengnb_NO
dc.publisherNTNUnb_NO
dc.relation.ispartofseriesDoctoral theses at NTNU;2017:231
dc.relation.haspartPaper 1: Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter. Nucleation and Growth of Brushite in the Presence of Alginate. Crystal Growth & Design 2015 ;Volum 15.(11) s. 5397-5405 https://doi.org/10.1021/acs.cgd.5b01032
dc.relation.haspartPaper 2: Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter. Transformation of brushite to hydroxyapatite and effects of alginate additives. Journal of Crystal Growth 2017 ;Volum 468. s. 774-780 https://doi.org/10.1016/j.jcrysgro.2016.11.019
dc.relation.haspartPaper 3: Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter. Transformation of Amorphous Calcium Phosphate to Hydroxyapatite in The Presence of Alginate Additives. The final published version is available in Crystal Growth & Design 2019 ;Volum 19.(12) s. 7077-7087 https://doi.org/10.1021/acs.cgd.9b00887
dc.relation.haspartSupplementary Paper 1: Bjørnøy, Sindre Hove; Bassett, David; Ucar, Seniz; Andreassen, Jens-Petter; Sikorski, Pawel. Controlled mineralisation and recrystallisation of brushite within alginate hydrogels. Biomedical Materials 2016 ;Volum 11.(1) https://doi.org/10.1088/1748-6041/11/1/015013
dc.relation.haspartSupplementary Paper 2: Bjørnøy, Sindre Hove; Bassett, David; Ucar, Seniz; Strand, Berit Løkensgard; Andreassen, Jens-Petter; Sikorski, Pawel. A correlative spatiotemporal microscale study of calcium phosphate formation and transformation within an alginate hydrogel matrix.. Acta Biomaterialia 2016 ;Volum 44. s. 254-266 https://doi.org/10.1016/j.actbio.2016.08.041
dc.titleThe Effects of Alginate Additives on Calcium Phosphate Mineralizationnb_NO
dc.typeDoctoral thesisnb_NO
dc.subject.nsiVDP::Technology: 500::Chemical engineering: 560nb_NO


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