Browsing NTNU Open by Author "Xing, Mengtan"
Now showing items 1-9 of 9
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53BP1 and BRCA1 control pathway choice for stalled replication restart
Xu, Yixi; Ning, Shaokai; Wei, Zheng; Xu, Ran; Xu, Xinlin; Xing, Mengtan; Guo, Rong; Xu, Dongyi (Journal article; Peer reviewed, 2017)The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated ... -
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Røsand, Øystein; Sarno, Antonio; Xing, Mengtan; Zhang, Qindong; Alirezaylavasani, Amin; Werner, Julia; Ji, Ping; Liabakk, Nina-Beate; Wang, Wei; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ... -
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells
Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ... -
Genetic interaction between the non-homologous end joining factors in mice and humans
Xing, Mengtan (Doctoral theses at NTNU;2019:117, Doctoral thesis, 2019) -
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF
Beck, Carole; Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2020)DNA double-strand breaks (DSBs) trigger the Ataxia telangiectasia mutated (ATM)-dependent DNA damage response (DDR), which consists of histone H2AX, MDC1, RNF168, 53BP1, PTIP, RIF1, Rev7, and Shieldin. Early stages of B ... -
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ... -
Robust DNA repair in PAXX-deficient mammalian cells
Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ... -
Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
Castañeda-Zegarra, Sergio; Xing, Mengtan; Gago-Fuentes, Raquel; Sæterstad, Siri; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ... -
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70
Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A.; Alt, Frederick W.; Oksenych, Valentyn (Journal article; Peer reviewed, 2017)DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds ...