Browsing NTNU Open by Author "Witter, Menno Peter"
Now showing items 1-11 of 11
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Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin
Courcelles, Erik Justin; Kjelsberg, Kasper; Convertino, Laura; Raveendran Nair, Rajeevkumar; Witter, Menno Peter; Nigro, Maximiliano Jose (Journal article; Peer reviewed, 2024)GABAergic neurons represent 10–15% of the neuronal population of the cortex but exert a powerful control over information flow in cortical circuits. The largest GABAergic class in the neocortex is represented by the ... -
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir (Peer reviewed; Journal article, 2023)Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part ... -
Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease
Stouffer, Kaitlin M.; Chen, Claire; Kulason, Sue; Xu, Eileen; Witter, Menno Peter; Ceritoglu, Can; Albert, Marilyn S.; Mori, Susumu; Troncoso, Juan; Tward, Daniel J.; Miller, Michael I. (Journal article; Peer reviewed, 2023) -
The efferent connections of theorbitofrontal, posterior parietal,and insular cortex of the rat brain
Reiten, Ingrid; Olsen, Grethe Mari; Bjaalie, Jan G.; Witter, Menno Peter; Leergaard, Trygve B. (Peer reviewed; Journal article, 2023)The orbitofrontal, posterior parietal, and insular cortices are sites of higher-order cognitive processing implicated in a wide range of behaviours, including working memory, attention guiding, decision making, and spatial ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
Norevik, Cecilie Skarstad; Huuha, Aleksi Matias; Røsbjørgen, Ragnhild; Bergersen, Linda Hildegard; Jacobsen, Kamilla; Miguel dos Santos, Rodrigo; Ryan, Liv; Skender, Belma; Bianco Nascimento Moreira, Jose; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Scrimgeour, Nathan Robert; Rafiee Tari, Atefe (Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents
Ohara, Shinya; Rannap, Märt; Tsutsui, Ken-Ichiro; Draguhn, Andreas; Egorov, Alexei V.; Witter, Menno Peter (Peer reviewed; Journal article, 2023)The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing ... -
Investigating the connectivity of the Hippocampus in a mouse model of congenital hypoplasia of the Dentate Gyrus
Kleven Tina (Master thesis, 2021)Hippocampus (HC) har en viktig rolle i læring og minne, og subregionen dentate gyrus (DG) er antatt å være av spesiell betydelig for å løse komplekse minneoppgaver ved å filtrere ny informasjon. For å gjøre dette utøver ... -
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter (Peer reviewed; Journal article, 2023)Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal Alzheimer’s disease. A ... -
Organization of projections from the entorhinal cortex to the hippocampal formation of the Egyptian fruit bat Rousettus aegyptiacus
Jacobsen, Bente; Kleven, Heidi; Gatome, Wairimu; Las, Liora; Ulanovsky, Nachum; Witter, Menno Peter (Peer reviewed; Journal article, 2023)The hippocampal formation and entorhinal cortex are crucially involved in learning and memory as well as in spatial navigation. The conservation of these structures across the entire mammalian lineage demonstrates their ... -
Projections of the insular cortex to orbitofrontal and medial prefrontal cortex: A tracing study in the rat
Mathiasen, Mathias; Aggleton, John P.; Witter, Menno Peter (Peer reviewed; Journal article, 2023)The dense fiber pathways that connect the insular cortex with frontal cortices are thought to provide these frontal areas with interoceptive information, crucial for their involvement in executive functions. Using anterograde ... -
Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways
Hovde, Karoline; Rautio, Ida Välikangas; Hegstad, Andrea Marie; Witter, Menno Peter; Whitlock, Jonathan Robert (Peer reviewed; Journal article, 2023)Introduction: The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. ...