• Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use 

      Liu, Ming; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M.; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; Mitchell, Amy; Skogholt, Anne Heidi; Sivertsen, Børge; Stordal, Eystein; Morken, Gunnar; Kallestad, Håvard; Heuch, Ingrid; Zwart, John-Anker; Fjukstad, Katrine Kveli; Pedersen, Linda Margareth; Johnsen, Marianne Bakke; Skrove, Marit Synnøve; Indredavik, Marit Sæbø; Drange, Ole Kristian; Bjerkeset, Ottar; Børte, Sigrid; Stensland, Synne; Choquet, Hélène; Docherty, Anna R.; Faul, Jessica D.; Foerster, Johanna R.; Fritsche, Lars; Gabrielsen, Maiken Elvestad; Gordon, Scott D.; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R.; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrú, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W.; Smith, Jennifer A.; Taylor, Amy E.; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A.; Zajac, Gregory J.M.; Zhao, Wei; Zhou, Wei; Björnsdóttir, Gyda Thora; Boardman, Jason D.; Boehnke, Michael; Boomsma, Dorret I.; Chen, Chu; Davies, Gareth E.; Eaton, Charles B.; Winsvold, Bendik K S; Hveem, Kristian; Vrieze, Scott (Journal article; Peer reviewed, 2019)
      Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery ...
    • Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study 

      Åsberg, Anders Nikolai; Hagen, Knut; Stovner, Lars Jacob; HEUCH, INGRID; Zwart, John-Anker; Winsvold, Bendik K S (Journal article; Peer reviewed, 2018)
      Background Musculoskeletal complaints (MSC) are common in the general population, causing a major disease burden to the individual and society. The association between MSC and mortality is still unclear. To our knowledge, ...
    • Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial 

      Bråten, Lars Christian Haugli; Rolfsen, Mads Peder; Espeland, Ansgar; Wigemyr, Monica; Assmus, Jörg; Froholdt, Anne; Haugen, Anne Julsrud; Marchand, Gunn Hege; Kristoffersen, Per M; Lutro, Olav; Randen, Sigrun; Wilhelmsen, Maja; Winsvold, Bendik K S; Kadar, Thomas; Holmgard, Thor Einar; Vigeland, Maria Dehli; Vetti, Nils; Nygaard, Øystein Petter; Lie, Benedicte Alexandra; Hellum, Christian; Anke, Audny; Grotle, Margreth; Schistad, Ellina Iordanova; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2019)
      Objective To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design Double ...
    • Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes 

      Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben Michael; Winsvold, Bendik K S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ...
    • Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008 

      Hagen, Knut; Åsberg, Anders Nikolai; Stovner, Lars Jacob; Linde, Mattias; Zwart, John-Anker; Winsvold, Bendik K S; HEUCH, INGRID (Journal article; Peer reviewed, 2018)
      Aims The aim of this population-based historical cohort study was to investigate the influence of lifestyle factors on the risk of developing migraine or tension-type headache (TTH). Methods Data from the Nord-Trøndelag ...
    • Migraine, obesity and body fat distribution - a population-based study 

      Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background: Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship ...
    • Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Stensland, Synne; Hagen, Knut; Winsvold, Bendik K S (Journal article; Peer reviewed, 2019)
      Background Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based ...
    • Praktisk håndtering av hodepine 

      Aamodt, Anne Hege; Bjørk, Marte-Helene; Alstadhaug, Karl Bjørnar; Eldøen, Guttorm; Dueland, Aud Nome; Poole, Tine; Hagen, Knut; Vetvik, Kjersti; Ofte, Hilde Karen; Sønnervik, Julie; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Lundqvist, Christofer; Sagabråten, Ståle Onsgår (Journal article; Peer reviewed, 2019)
      Korrekt diagnostikk av ulike hodepinetyper kan være utfordrende, men det er den viktigste forutsetningen for optimal behandling. Det anbefales kontrollert bruk av anfallsmedisin og forebyggende tiltak. Hodepinesykdommer ...
    • Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995–1997 and 2006–2008 

      Hagen, Knut; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Stovner, Lars Jacob; Zwart, John-Anker (Journal article; Peer reviewed, 2018)
      Objectives To estimate remission rates of chronic headache and predictors of remission. Methods In this longitudinal population-based cohort study, we used validated headache questionnaire data from the second (1995–1997, ...
    • Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants 

      Winsvold, Bendik K S; Bettella, Francesco; Witoelar, A; Anttila, Verneri; Gormley, Padhraig; Kurth, Tobias; Terwindt, Gisela M; Freilinger, Tobias; Frei, Oleksandr; Shadrin, Alexey A.; Wang, Yunpeng; Dale, Anders; Van Den Maagdenberg, Arn M.J.M.; Chasman, Daniel I; Nyholt, Dale R; Palotie, Aarno; Andreassen, Ole Andreas; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Migraine is a recurrent pain condition traditionally viewed as a neurovascular disorder, but little is known of its vascular basis. In epidemiological studies migraine is associated with an increased risk of cardiovascular ...
    • The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study 

      Johnsen, Marianne Bakke; Winsvold, Bendik K S; Børte, Sigrid; Vie, Gunnhild Åberge; Pedersen, Linda Margareth; Storheim, Kjersti; Skorpen, Frank; Hagen, Knut; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)
      Background and purpose Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity ...
    • The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study 

      Johnsen, Marianne Bakke; Vie, Gunnhild Åberge; Winsvold, Bendik K S; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Pedersen, Linda Margareth; Hellevik, Alf Inge; Langhammer, Arnulf; Furnes, Ove; Flugsrud, Gunnar B; Skorpen, Frank; Romundstad, Pål Richard; Storheim, Kjersti; Nordsletten, Lars; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Objective Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ...
    • The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008 

      Hagen, Knut; Stovner, Lars Jacob; Nilsen, Kristian Bernhard; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S (Journal article; Peer reviewed, 2019)
      Background Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see ...