Browsing NTNU Open by Author "Thommesen, Liv"
Now showing items 1-20 of 39
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A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
Flobak, Åsmund; Niederdorfer, Barbara; To, Vu; Thommesen, Liv; Klinkenberg, Geir; Lægreid, Astrid (Journal article; Peer reviewed, 2019)While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual ... -
Automatisert ELISA metode for påvisning av IAA
Dørum, Therese; Andersen, Jenny Lund (Bachelor thesis, 2023)Bakgrunn: Enhet for immunologi har automatisert flere ELISA-tester, men fortsatt er det fem tester som utføres manuelt. Prosjektets hensikt er derfor å undersøke om en automatisering av en ELISA-test for insulin autoantistoff ... -
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles
Heck, Kathleen; Lindholm, Håvard Takle; Niederdorfer, Barbara; Tsirvouli, Eirini; Kuiper, Martin; Flobak, Åsmund; Lægreid, Astrid Renner; Thommesen, Liv (Journal article; Peer reviewed, 2023) -
Characterization of Mam301 in Fission yeast
Eidsmo, Nina Winje (Bachelor thesis, 2022)Background: Magnesium is an essential ion that is a cofactor for many important proteins and enzymes in the body. It also functions as a counterion for negative ions and thus helps stabilize many important molecules. ... -
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Kuiper, Martin; Lægreid, Astrid; Flobak, Åsmund; Thommesen, Liv; Team, Dream (Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Digital opplæring i urinmikroskopi
Hjelleset, Terese; Thomassen, Madelen Kristine (Bachelor thesis, 2020)Det er utfordrende å få tak i ferske nok uriner som inneholder tilstrekkelige variasjoner av normale og patologiske funn til opplæring i urinmikroskopi. Det har derfor lenge vært av interesse for både bioingeniørutdanningene ... -
Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling
Flobak, Åsmund; Baudot, Anaïs; Remy, Elisabeth; Thommesen, Liv; Thieffry, Denis; Kuiper, Martin; Lægreid, Astrid (Peer reviewed; Journal article, 2015)Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses ... -
Etablering av Real-Time PCR for deteksjon av Cutibacterium acnes
Kupen, Marita; Fredheim, Katrine Weilin (Bachelor thesis, 2021)Cutibacterium acnes er en gram positiv, anaerob stavbakterie som inngår i hudens normalflora. Bakterien kan være årsak til postoperative infeksjoner, da bakterien fester seg til proteser og kirurgisk utstyr. Per i dag ... -
Experimental-Computational Approaches to Identify Synergistic Effects of Anti-Cancer Drugs
Niederdorfer, Barbara (Doctoral theses at NTNU;2019:384, Doctoral thesis, 2019)Drug combinations are hoped to improve treatment response to anti-cancer drugs by targeting the cancers vulnerabilities at diverse trajectories. With a large number of approved agents of chemotherapeutic and targeted ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
Rao, Shalini; Solum, Guri; Niederdorfer, Barbara; Nørsett, Kristin; Bjørkøy, Geir; Thommesen, Liv (Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort
Tripathi, Sushil; Christie, K R; Balakrishnan, Ravin; Huntley, R; Hill, D P; Thommesen, Liv; Blake, J A; Kuiper, Martin; Lægreid, Astrid (Journal article; Peer reviewed, 2013)Transcription factors control which information in a genome becomes transcribed to produce RNAs that function in the biological systems of cells and organisms. Reliable and comprehensive information about transcription ... -
Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort
Tripathi, Sushil; Christie, KR; Balakrishnan, Ravin; Huntley, R; Hill, DP; Thommesen, Liv; Blake, JA; Kuiper, Martin; Lægreid, Astrid (Journal article; Peer reviewed, 2013)Transcription factors control which information in a genome becomes transcribed to produce RNAs that function in the biological systems of cells and organisms. Reliable and comprehensive information about transcription ... -
Gene regulation knowledge commons: community action takes care of DNA binding transcription factors
Tripathi, Sushil; Vercruysse, Steven; Chawla, Konika; Christie, Karen R.; Blake, Judith A; Huntley, Rachael P.; Orchard, Sandra; Hermjakob, Henning; Thommesen, Liv; Lægreid, Astrid; Kuiper, Martin (Journal article; Peer reviewed, 2016)A large gap remains between the amount of knowledge in scientific literature and the fraction that gets curated into standardized databases, despite many curation initiatives. Yet the availability of comprehensive knowledge ... -
Gene regulation knowledge commons: community action takes care of DNA binding transcription factors
Tripathi, Sushil; Vercruysse, Steven; Chawla, Konika; Christie, Karen R.; Blake, Judith A; Huntley, Rachael P.; Orchard, Sandra; Hermjakob, Henning; Thommesen, Liv; Lægreid, Astrid; Kuiper, Martin (Journal article; Peer reviewed, 2016)A large gap remains between the amount of knowledge in scientific literature and the fraction that gets curated into standardized databases, despite many curation initiatives. Yet the availability of comprehensive knowledge ... -
High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
Folkesson, Evelina; Niederdorfer, Barbara; To, Vu; Thommesen, Liv; Klinkenberg, Geir; Lægreid, Astrid; Flobak, Åsmund (Peer reviewed; Journal article, 2020)Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on ... -
Holdbarhetsstudie - kjølig oppbevaring av prøver til analyse av PT-INR
Matberg, Karianne; Martinsen, Stine Karoline (Bachelor thesis, 2020)I dette forsøket ble det utført en holdbarhetsstudie hvor det ble undersøkt om blodprøver oppbevart kjølig (5°C) kunne gi et signifikant endret analysesvar i forhold tilsvarende prøve oppbevart i romtemperatur. Dette ble ... -
Identification of metastasis-associated microRNAs in serum from rectal cancer patients
Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ... -
Identification of MicroRNA Expression in Gastrin Stimulated Adenocarcinoma Cells
Bergly, Laila H. (Master thesis, 2011)The Gastrin System Biology group studies the molecular responses to gastrin using cell line model systems. Recently microRNAs (miRNAs) have been acknowledged as essential participants in the regulation of gene expression, ... -
In vitro validation of anticancer drug combinations on colon cancer cell lines SW620 and HCT116
Greina, Marianne (Master thesis, 2018)Combinatory drug treatment, e.g. targeting different proteins in specific signaling pathways tailored to an individual’s tumor, is expected to overcome problems related to individual variation in drug efficacy, resistance ... -
Molecular mechanisms involved in TNF - and gastrin-mediated gene regulation
Thommesen, Liv (Dissertations at the Faculty of Medicine, 0805-7680; 189, Doctoral thesis, 2001)Cells in a multicellular organism depend on extensive communication with each other. Eukaryotic cells have developed elaborate signal transduction systems by which externally provided information (hormones, cytokines, ...