• Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study 

      Johnsen, Marianne Bakke; Magnusson, Karin; Børte, Sigrid; Gabrielsen, Maiken Elvestad; Winsvold, Bendik K S; Skogholt, Anne Heidi; Thomas, Laurent; Storheim, Kjersti; Hveem, Kristian; Zwart, John-Anker (Peer reviewed; Journal article, 2020)
      Objective To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design We included 17,153 men and 18,682 ...
    • Inferring causative variants in microRNA target sites 

      Thomas, Laurent; Saito, Takaya; Sætrom, Pål (Journal article; Peer reviewed, 2011)
      MicroRNAs (miRNAs) regulate genes post transcription by pairing with messenger RNA (mRNA). Variants such as single nucleotide polymorphisms (SNPs) in miRNA regulatory regions might result in altered protein levels and ...
    • Mitochondrial genome-wide association study of migraine – the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ...
    • Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation 

      Thomas, Laurent; Sætrom, Pål (Journal article; Peer reviewed, 2012)
      Alternative polyadenylation (APA) can for example occur when a protein-coding gene has several polyadenylation (polyA) signals in its last exon, resulting in messenger RNAs (mRNAs) with different 3′ untranslated region ...
    • The eGenVar data management system-cataloguing and sharing sensitive data and metadata for the life sciences 

      Razick, Sabry; Mocnik, Rok; Thomas, Laurent; Ryeng, Einar; Drabløs, Finn; Sætrom, Pål (Journal article; Peer reviewed, 2014)
      Systematic data management and controlled data sharing aim at increasing reproducibility, reducing redundancy in work, and providing a way to efficiently locate complementing or contradicting information. One method of ...