Browsing NTNU Open by Author "Sundby, Eirik"
Now showing items 1-20 of 47
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Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena
Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge (Journal article; Peer reviewed, 2012) -
Addressing Analytical Challenges in Global Metabolomics: Application of Isotope-labeled Internal Standards for Quality Assurance
Havikbotn, Ida (Bachelor thesis, 2024)Global metabolomikk er en omfattende analytisk tilnærming som er designet for å identifisere alle metabolitter i en biologiske prøve. Metoden er verdifull i klinisk diagnostikk, men den manglende spesifisiteten er en ... -
Alchemical Non-Equilibrium Free Energy Calculations Of CSF-1R Inhibitors
Tiller, Julie Lovise (Master thesis, 2022)Abstract will be available on 2025-02-01 -
Analyse av klorider i støvmålinger ved bruk av nye prøvepunkter og modifisert prøvetakingsutstyr for å kvalitetssikre utslippsdata
Jacobsen, Ida Emilie Malde; Mikalsen, Karina; Sanden, Ylva (Bachelor thesis, 2019)I denne rapporten var hovedmålet å bestemme om det var klorider i støvutslippet fra renseanlegget til Hydro Sunndal. Dette ble utført ved å ta i bruk nye prøvepunkter og modifisert prøvetakingsutstyr for å få nøyaktige ... -
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2016)The present study describes our continuous effort to develop epidermal growth factor receptor (EGFR) inhibitors based on the 6-aryl-pyrrolo[2,3-d]pyrimidin-4-amine scaffold. The activity-ADME space has been evaluated by ... -
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Biological reductions and esterifications for the production of enantiopure secondary alcohols : chemo-enzymatic synthesis of chiral building blocks with sulphur-containing rings
Sundby, Eirik (Doktoravhandlinger ved NTNU, 1503-8181, Doctoral thesis, 2003)Both enantiomers of 1-(1,3-dithian-2-yl)-2-propanol ( 5 ) 1-(1,3-dithiolan-2-yl)-2- propanol (6), and halogenated derivatives of 5 was obtained by microbial reductions and lipase catalyzed esterifications. (2S)-1-(1,3-di ... -
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit (Journal article; Peer reviewed, 2017)Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins ... -
Comparison of Students' Perceived Learning in Two Similar Lab Courses with Different Teaching Staffs
Sundby, Eirik; Haugen, Ingrid Naterstad (Journal article, 2020)At the Norwegian University of Science and Technology (NTN), two subjects with similar chemistry laboratory exercises have different practices with respect to the use of permanent and temporary staffs. In an ever-increasing ... -
Development of a Novel Archaeological Cleaning Method for Copper Alloys using Xanthan Gum
Bjerkeengen, Sunniva Sørlien; Bolghaug, Eirik Olav; Fromreide, Håvard Martin (Bachelor thesis, 2023)Hensikten med dette prosjektet var å teste ut en ny arkeologisk rensemetode ut fra forslag fra NTNU Universitetsmuseumet. Idéen bak rensemetoden var å teste ut xantan gel, en hydrogel som vil gjøre det enklere å ha kontroll ... -
Development of Reference Materials for Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH)
Markussen, Sandra Vedvik (Bachelor thesis, 2024)Denne bacheloroppgaven har som mål å utvikle referansematerialer for mineralolje mettede hydrokarboner (MOSH) og mineralolje aromatiske hydrokarboner (MOAH), som er avgjørende for kromatografisk analyse innen mattrygghet ... -
Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether
Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)Pyrrolopyrimidines are important scaffolds for the preparation of bioactive molecules. Therefore, developing efficient and flexible ways for selective functionalization of the pyrrolopyrimidine skeleton is of interest. We ... -
Enantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral amines
El-Behairy, Mohammed Farrag; Hassan, Rasha M.; Sundby, Eirik (Peer reviewed; Journal article, 2021)Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or ... -
Enantioselectivity, swelling and stability of 4-hydroxyprolinol containing acrylic polymer beads in the asymmetric reduction of ketones
Thvedt, Thor Håkon Krane; Kristensen, Tor Erik Holt; Sundby, Eirik; Hansen, Tore; Hoff, Bård Helge (Journal article; Peer reviewed, 2011)A new 4-hydroxy-a,a-diphenyl-L-prolinol containing polymethacrylate, prepared without chromatography by a large scale adaptable synthesis, has been evaluated as a catalyst in the asymmetric reduction of 1-arylethanones. ... -
Etablere, optimalisere og validere komposisjonsanalyse for rikgass i henhold til ASTM D1945, ISO6975, GPA2286, eller ekvivalent, med kvantifisering av metan til dekan
Åstrøm, Lars-Erik; Eriksen, Vermund (Bachelor thesis, 2020)Oppgavens hensikt var å etablere en gasskromatografisk analysemetode av naturgass for kvantifisering av hydrokarbonene metan til dekan i henhold til standardene ASTM D1945, ISO6975 og GPA2286. Gasskromatograf ble levert ... -
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lise Marie; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals and public healthcare systems. At the same time drug development is lagging behind. Therefore, finding new ways of treating ... -
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, ... -
Identification of fused pyrimidines as interleukin 17 secretion inhibitors
Reiersølmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2018)Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases. Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors using a phenotypic assay with peripheral ...