• Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation 

      Thorolfsdottir, Rosa B; Sveinbjornsson, Gardar; Sulem, Patrick; Nielsen, Jonas B.; Jonsson, Stefan; Halldorsson, Gisli H; Melsted, Pall; Ivarsdottir, Erna V; Davidsson, Olafur B; Kristjansson, Ragnar P; Thorleifsson, Gudmar; Helgadottir, Anna; Gretarsdottir, Solveig; Norddahl, Gudmundur; Rajamani, Sridharan; Torfason, Bjarni; Valgardsson, Atli S; Sverrisson, Jon T.; Tragante, Vinicius; Holmen, Oddgeir Lingaas; Asselbergs, Folkert W; Roden, Dan M; Darbar, Dawood; Pedersen, Terje Rolf; Sabatine, Marc S.; Willer, Cristen J.; Løchen, Maja-Lisa; Halldorsson, Bjarni V; Jonsdottir, Ingileif; Hveem, Kristian; Arnar, David O; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel F.; Holm, Hilma; Stefansson, Kari (Journal article; Peer reviewed, 2018)
      Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding variants associated with risk through unknown mechanisms. We performed a meta-analysis of ...
    • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes 

      Gusarova, Viktoria; O'Dushlaine, Colm; Teslovich, Tanya M.; Benotti, Peter N.; Mirshahi, Tooraj; Gottesman, Omri; van Hout, Cristopher V.; Murray, Michael F.; Mahajan, Anubha; Nielsen, Jonas B.; Fritsche, Lars; Wulff, Anders Berg; Gudbjartsson, Daníel Fannar; Sjögren, Marketa; Emdin, Connor A.; Scott, Robert A.; Lee, Wen-Jane; Small, Aeron; Kwee, Lydia C.; Dwivedi, Om Prakash; Prasad, Rashmi B.; Bruse, Shannon; Lopez, Alexander E.; Penn, John; Marcketta, Anthony; Leader, Joseph B.; Still, Christopher D.; Kirchner, H. Lester; Mirshahi, Uyenlinh L.; Wardeh, Amr H.; Hartle, Cassandra M.; Habegger, Lukas; Fetterolf, Samantha N.; Tusie-Luna, Teresa; Morris, Andrew P.; Holm, Hilma; Steinthorsdóttir, Valgerdur; Sulem, Patrick; Thorsteinsdóttir, Unnur; Rotter, Jerome I.; Chuang, Lee-Ming; Damrauer, Scott; Birtwell, David; Brummett, Chad M.; Khera, Amit V.; Natarajan, Pradeep; Orho-Melander, Marju; Flannick, Jason; Lotta, Luca A.; Willer, Cristen J.; Holmen, Oddgeir Lingaas; Ritchie, Marylyn D.; Ledbetter, David H.; Murphy, Andrew J.; Borecki, Ingrid B.; Reid, Jeffrey G.; Overton, John D.; Hansson, Ola; Groop, Leif; Shah, Svati H.; Kraus, William E.; Rader, Daniel J.; Chen, Yii-Der Ida; Hveem, Kristian; Wareham, Nicholas J.; Kathiresan, Sekar; Melander, Olle; Stefansson, Kari; Nordestgaard, Børge G.; Tybjærg-Hansen, Anne; Abecasis, Goncalo; Altshuler, David; Florez, Jose C.; Boehnke, Michael; McCarthy, Mark I.; Yancopoulos, George D.; Carey, David J.; Shuldiner, Alan R.; Baras, Aris; Dewey, Frederick E.; Gromada, Jesper (Journal article; Peer reviewed, 2018)
      Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve ...
    • Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma 

      Swaminathan, Bhairavi; Thorleifsson, Gudmar; Jöud, Magnus; Ali, Mina; Johnsson, Ellinor; Ajore, Ram; Sulem, Patrick; Halvarsson, Britt-Marie; Eyjolfsson, Gudmundur I.; Haraldsdottir, Vilhelmina; Hultman, Christina; Ingelsson, Erik; Kristinsson, Sigurdur Y; Kähler, Anna Katarina; Lenhoff, Stig; Masson, Gisli; Mellqvist, Ulf-Henrik; Månsson, Robert; Nelander, Sven; Olafsson, Isleifur; Sigurdardóttir, Olöf Gudrun; Steingrimsdottir, Hlif; Vangsted, Annette; Vogel, Ulla; Waage, Anders; Nahi, Hareth; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Turesson, Ingemar; Gullberg, Urban; Stefansson, Kari; Hansson, Markus; Thorsteinsdottir, Unnur; Nilsson, Björn (Journal article; Peer reviewed, 2015)
      Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is ...