Blar i NTNU Open på forfatter "Steinkjer, Bjørg"
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Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
Gravastrand, Caroline; Hamad, Shamal; Fure, Hilde; Steinkjer, Bjørg; Ryan, Liv; Oberholzer, José; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Brekke, Ole-Lars; Rokstad, Anne Mari (Journal article; Peer reviewed, 2017)Alginate microspheres are presently under evaluation for future cell-based therapy. Their ability to induce harmful host reactions needs to be identified for developing the most suitable devices and efficient prevention ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lacík, Igor; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Changes in serum cytokines throughout pregnancy in women with polycystic ovary syndrome
Stokkeland, Live Marie; Giskeødegård, Guro F.; Ryssdal, Mariell; Jarmund, Anders Hagen; Steinkjer, Bjørg; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Løvvik, Tone Shetelig; Iversen, Ann-Charlotte; Vanky, Eszter (Journal article; Peer reviewed, 2021)Context: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system in pregnancy ... -
Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje; Rokstad, Anne Mari (Journal article; Peer reviewed, 2019)Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we ... -
Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond
Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ... -
Functional Toll-like receptors in primary first-trimester trophoblasts
Tangerås, Line; Stødle, Guro; Olsen, Guro Dalheim; Leknes, Ann-Helen; Gundersen, Astrid; Skei, Bente; Vikdal, Anne Jorunn; Ryan, Liv; Steinkjer, Bjørg; Myklebost, Merete; Langaas, Mette; Austgulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2014)Toll-like receptors (TLRs) are an important part of the body's danger response system and crucial for initiating inflammation in response to cellular stress, tissue damage, and infections. Proper placental development is ... -
Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS
Ryssdal, Mariell; Vanky, Eszter Ilona; Stokkeland, Live Marie T; Jarmund, Anders Hagen; Steinkjer, Bjørg; Løvvik, Tone Shetelig; Madssen, Torfinn Støve; Iversen, Ann-Charlotte; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2023)Context: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade systemic inflammation and increased risk of pregnancy complications. Metformin treatment reduces the risk of late miscarriage ... -
In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads
Vaithilingam, Vijayaganapathy; Steinkjer, Bjørg; Ryan, Liv; Larsson, Rolf; Tuch, Bernard E.; Oberholzer, José; Rokstad, Anne Mari (Journal article; Peer reviewed, 2017)Host reactivity to biocompatible immunoisolation devices is a major challenge for cellular therapies, and a human screening model would be of great value. We designed new types of surface modified barium alginate microspheres, ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
Giambelluca, Miriam Soledad; Markova, Elena; Louet, Claire; Steinkjer, Bjørg; Sundset, Rune; Skalko Basnet, Natasa; Hak, Sjoerd (Journal article; Peer reviewed, 2023)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed ... -
Serum cytokine patterns in first half of pregnancy
Stokkeland, Live Marie Tobiesen; Giskeødegård, Guro F.; Stridsklev, Solhild; Ryan, Liv; Steinkjer, Bjørg; Tangerås, Line Haugstad; Vanky, Eszter; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Introduction Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex ...