• A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

      Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2019)
      Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ...
    • Mechanical properties of 67NR tumours are broadly independent of the immune status of the host mouse 

      Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Dille, Morten Johnsen; Steigedal, Tonje S.; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)
      Tumour stiffness is increasingly seen as a clinically relevant parameter, with increased stiffness being linked to poorer prognosis, but it is also one that is not inherently easy to measure either in vivo or ex vivo. We ...
    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Peer reviewed; Journal article, 2021)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ...
    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...
    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2018)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ...
    • Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judit; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg (Peer reviewed; Journal article, 2020)
      This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial ...
    • Systems Medicine: From Modeling Systems Perturbations to Predicting Drug Synergies 

      Flobakk, Åsmund (Doctoral thesis at NTNU;2016:55, Doctoral thesis, 2016)
      Computational approaches to systems biology and systems medicine enable the study of systems properties that emerge from integrating knowledge about complex interactions, such as in the study of cancer cell phenotypes ...
    • Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy 

      Søgaard, Caroline Krogh; Nepal, Anala; Petrovic, Voin; Sharma, Animesh; Liabakk, Nina-Beate; Steigedal, Tonje S.; Otterlei, Marit (Journal article, 2019)
      Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ...