• 18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report 

      Johannessen, Knut; Berntsen, Erik Magnus; Johansen, Håkon; Solheim, Tora S; Karlberg, Anna Maria; Eikenes, Live (Peer reviewed; Journal article, 2021)
      Abstract Background: Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in ...
    • Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series 

      Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger; Bye, Asta; Greil, Christine; Arends, Jann; Baracos, Vickie; Brown, Leo R.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie; Fraser, Eilidh; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Kaasa, Stein; McDonald, James; Philips, Iain; Sayers, Judith; Simpson, Melanie Rae; Sousa, Mariana S.; Skipworth, Richard J.E.; Laird, Barry J.A.; Solheim, Tora S (Journal article; Peer reviewed, 2024)
      There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and ...
    • Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit 

      Helgesen, Elisabeth Hagen; Ulevåg, Ragnhild; Solheim, Tora S; Thronæs, Morten; Jakobsen, Gunnhild; Løhre, Erik Torbjørn; Balstad, Trude Rakel; Vagnildhaug, Ola Magne (Journal article; Peer reviewed, 2024)
      Appetite loss is prevalent in patients with advanced cancer and negatively affects their quality of life. However, understanding of the factors associated with appetite loss is limited. The current study aims to explore ...
    • Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series 

      Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Peer reviewed, 2024)
      Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement ...
    • Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series 

      Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Peer reviewed, 2024)
      Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most ...
    • Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines☆ 

      Arends, Jann; Strasser, Florian; Gonella, Silvia; Solheim, Tora S; Madeddu, Christina; Ravasco, Paula; Buonaccorso, Loredana; de van der Schueren, Marion; Baldwin, Christine; Chasen, Martin; Ripamonti, Carla (Peer reviewed; Journal article, 2021)
    • Diagnostic Value of 18F-FACBC PET/MRI in Brain Metastases 

      Øen, Silje Kjærnes; Johannessen, Knut; Pedersen, Lars Kjelsberg; Berntsen, Erik Magnus; Totland, Jon Andre; Johansen, Håkon; Bogsrud, Trond Velde; Solheim, Tora S; Karlberg, Anna Maria; Eikenes, Live (Peer reviewed; Journal article, 2022)
      Purpose The study aims to evaluate whether combined 18F-FACBC PET/MRI could provide additional diagnostic information compared with MRI alone in brain metastases. Patients and Methods Eighteen patients with newly ...
    • Do older patients with colorectal cancer experience more deterioration in health-related quality of life than younger patients during the first year of palliative chemotherapy? A prospective real-world observational study 

      Hatlevoll, Ingunn; Kristensen, Are Korsnes; Solheim, Tora S; Elvebakken, Hege; Salvesen, Øyvind Olav; Oldervoll, Line Merethe; Wibe, Arne; Hofsli, Eva (Journal article; Peer reviewed, 2024)
      Introduction: The primary aim was to evaluate changes in health-related quality of life (HRQoL) in a real-life population among younger (< 70 years) and older patients with metastatic colorectal cancer (mCRC) during the ...
    • Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients with Recurrent Glioblastoma: A Randomized Clinical Trial 

      Werlenius, Katja; Kinhult, Sara; Solheim, Tora S; Magelssen, Henriette; Löfgren, David; Mudaisi, Munila; Hylin, Sofia; Bartek, Jiri; Strandéus, Michael; Lindskog, Magnus; Rashid, Havyan Bahroz; Carstam, Louise; Gulati, Sasha; Solheim, Ole Skeidsvoll; Salvesen, Øyvind Olav; Jakola, Asgeir Store (Peer reviewed; Journal article, 2023)
      Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective To evaluate the efficacy and safety of ...
    • Emergency Palliative Cancer Care: Dexmedetomidine Treatment Experiences—A Retrospective Brief Report on Nine Consecutive Cases 

      Løhre, Erik Torbjørn; Svedahl, Augstein; Jakobsen, Gunnhild; Solheim, Tora S; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)
      Introduction Dexmedetomidine, an alpha-2 adrenergic receptor agonist with potential opioid sparing properties, is utilized in palliative medicine, but the knowledge base for this practice is limited. We describe concomitant ...
    • ESPEN practical guideline: Clinical Nutrition in cancer 

      Muscaritoli, Maurizio; Arends, Jann; Bachmann, Patrick; Baracos, Vickie E.; Barthelemy, Nicole; Bertz, Hartmut; Bozzetti, Federico; Hütterer, Elisabeth; Isenring, Elizabeth; Kaasa, Stein; Krznaric, Zeljko; Laird, Barry J.A.; Larsson, Maria; Laviano, Alessandro; Mühlebach, Stefan; Oldervoll, Line Merethe; Ravasco, Paula; Solheim, Tora S; Strasser, Florian; van Bokhorst- De van der Schue, M; Preiser, Jean-Charles; Bischoff, Stephan C. (Peer reviewed; Journal article, 2021)
      Background This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients. Methods ESPEN guidelines have been shortened and transformed into flow charts for easier use in ...
    • Exploring the barriers to diagnosing malnutrition in patients with cancer: A study on oncologists' perspectives 

      Koteng, Lisa Heide; Sand, Kari; Paur, Ingvild; Bye, Asta; Ervik, Bente; Solheim, Tora S; Ottestad, Inger; Balstad, Trude Rakel (Journal article; Peer reviewed, 2024)
      Background and aim: Patients with cancer are at high risk of malnutrition, yet relevant ICD-10 codes for malnutrition are underutilized in cancer clinics. Understanding oncologists' perspectives is crucial for optimizing ...
    • Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study 

      Thronæs, Morten; Løhre, Erik T; Kvikstad, Anne; Brenne, Elisabeth; Norvaag, Robin; Aalberg, Kathrine Otelie; Moen, Martine Kjølberg; Jakobsen, Gunnhild; Klepstad, Pål; Solberg, Arne; Solheim, Tora S (Journal article; Peer reviewed, 2021)
      Purpose To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services. Methods All ...
    • Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden 

      Heggebø, Liv Cathrine; Borgen, Ida Maria Henriksen; Rylander, Hillevi; Kiserud, Cecilie E.; Nordenmark, Tonje Kristin Haug; Hellebust, Taran Annette Paulsen; Evensen, Morten Egeberg; Gustavsson, Magnus; Ramberg, Christina; Sprauten, Mette; Magelssen, Henriette; Blakstad, Hanne; Moorthy, Janani; Andersson, Karin; Raunert, Ingela; Henry, Thomas; Moe, Cecilie; Granlund, Carin; Goplen, Dorota; Brekke, Jorunn; Johannessen, Tor-Christian Aase; Solheim, Tora S; Marienhagen, Kirsten; Humberset, Øyvind; Bergström, Per; Agrup, Måns; Dahl, Ludvig; Gubanski, Michael; Gojon, Helene; Brahme, Carl-Johan; Rydén, Isabelle; Jakola, Asgeir Store; Vik-Mo, Einar O.; Lie, Hanne Cathrine; Asphaug, Lars; Hervani, Maziar; Kristensen, Ingrid; Rüegg, Corina Silvia; Olsen, Inge Christoffer; Ledal, Rolf J; Degsell, Eskil; Werlenius, Katja; Blomstrand, Malin; Brandal, Petter (Peer reviewed; Journal article, 2023)
      Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ...
    • Midazolam Indications and Dosing in Palliative Medicine: Results from a Multinational Survey 

      Tranung, Morten; Solheim, Tora S; Løhre, Erik Torbjørn; Marsaa, Kristoffer; Haugen, Dagny Renata Faksvåg; Laird, Barry; Thronæs, Morten; Larsen, Michael Due (Peer reviewed; Journal article, 2024)
      Despite sparse evidence and limited guidance on indications, use, and dosing, midazolam is widely used in palliative care. We aimed to describe and compare the use of midazolam in three different countries to improve ...
    • Parenteral Nutrition in Advanced Cancer: The Healthcare Providers’ Perspective 

      Balstad, Trude Rakel; Løhre, Erik T; Thoresen, Lene; Thronæs, Morten; Skjelvan, Laila Strand; Helgås, Ragnhild Green; Solheim, Tora S; Sand, Kari (Peer reviewed; Journal article, 2022)
      Introduction The evidence base for parenteral nutrition (PN) in advanced cancer patients is limited. We studied healthcare providers’ (HCPs’) experiences with PN in cancer patients, focusing on perceived treatment benefits ...
    • Parenteral Nutrition in Palliative Cancer Care: Detrimental, Futile, or Beneficial? 

      Løhre, Erik Torbjørn; Solheim, Tora S; Jakobsen, Gunnhild; Vagnildhaug, Ola Magne; Karlsen, Terese Louise Schmidberger; Habberstad, Ragnhild Hansdatter; Balstad, Trude Rakel; Thronæs, Morten (Journal article; Peer reviewed, 2024)
      Palliative cancer care patients may live for a long time, but malnutrition worsens the prognosis. Parenteral nutrition (PN) is suitable for replenishing a calorie deficit, but its advantages and tolerance late in the cancer ...
    • Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series 

      McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie; Brown, Leo; Bye, Asta; Dajani, Olav; Dolan, Ross; Fallon, Marie T.; Fraser, Eilidh; Griel, Christine; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jamal-Hanjani, Mariam; Jakobsen, Gunnhild; Kaasa, Stein; McMillan, Donald; Maddocks, Matthew; Philips, Iain; Ottestad, Inger; Reid, Kieran F.; Sousa, Mariana S.; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Skipworth, Richard J. E.; Solheim, Tora S; Laird, Barry J (Peer reviewed; Journal article, 2023)
      In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, ...
    • Physical rehabilitation in patients with head and neck cancer: Impact on health-related quality of life and suitability of a post-treatment program 

      Sandmæl, Jon Arne; Bye, Asta; Solheim, Tora S; Balstad, Trude Rakel; Thorsen, Lene; Skovlund, Eva; Kaasa, Stein; Lund, Jo-Åsmund; Oldervoll, Line Merethe (Peer reviewed; Journal article, 2020)
      Objective: Physical rehabilitation programs hold the potential to mitigate deterioration in health-related quality of life (HRQoL) in patients with head and neck cancer. The objective was to assess development in relevant ...
    • Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series 

      Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Coats, Andrew J.S.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Grzyb, Alexandra; Kaasa, Stein; Koteng, Lisa Heide; May, Anne M.; McDonald, James; Ottestad, Inger; Philips, Iain; Roeland, Eric J.; Sayers, Judith; Simpson, Melanie Rae; Skipworth, Richard J.E.; Solheim, Tora S; Sousa, Mariana S.; Vagnildhaug, Ola Magne; Laird, Barry J.A. (Journal article; Peer reviewed, 2024)
      The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. ...