Blar i NTNU Open på forfatter "Sofias, Alexandros Marios"
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Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes
Combes, Francis; Sofias, Alexandros Marios; Mc Cafferty, Séan; Huysmans, Hanne; De Temmerman, Joyca; Hak, Sjoerd; Meyer, Evelyne; Sanders, Niek N (Peer reviewed; Journal article, 2019)Tumor associated macrophages are an essential part of the tumor microenvironment. Consequently, bone marrow-derived monocytes (BMDMs) are continuously recruited to tumors and are therefore seen as ideal delivery vehicles ... -
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice
Sofias, Alexandros Marios; Åslund, Andreas; Hagen, Nils; Grendstad, Kristin; Hak, Sjoerd (Peer reviewed; Journal article, 2019)Purpose The endeavor of deciphering intricate phenomena within the field of molecular medicine dictates the necessity to investigate tumor/disease microenvironment real-time on cellular level. We, hereby, design simple and ... -
Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment
de Maar, Josanne Sophia; Sofias, Alexandros Marios; Porta Siegel, Tiffany; Vreeken, Rob J.; Moonen, Chrit; Bos, Clemens; Deckers, Roel (Journal article; Peer reviewed, 2020) -
Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation
Toner, Yohana C.; Ghotbi, Adam A.; Naidu, Sonum; Sakurai, Ken; van Leent, Mandy M. T.; Jordan, Stefan; Ordikhani, Farideh; Amadori, Letizia; Sofias, Alexandros Marios; Fisher, Elizabeth L.; Maier, Alexander; Sullivan, Nathaniel; Munitz, Jazz; Senders, Max L.; Mason, Christian; Reiner, Thomas; Soultanidis, Georgios; Tarkin, Jason M.; Rudd, James H. F.; Giannarelli, Chiara; Ochando, Jordi; Pérez-Medina, Carlos; Kjaer, Andreas; Mulder, Willem J. M.; Fayad, Zahi A.; Calcagno, Claudia (Peer reviewed; Journal article, 2022)In recent years, cardiovascular immuno-imaging by positron emission tomography (PET) has undergone tremendous progress in preclinical settings. Clinically, two approved PET tracers hold great potential for inflammation ... -
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ... -
Unraveling the multifaceted in vivo fate of cancer nanomedicine
Sofias, Alexandros Marios (Doctoral theses at NTNU;2019:369, Doctoral thesis, 2019)