Browsing NTNU Open by Author "Snipstad, Sofie"
Now showing items 1-20 of 38
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Acoustic Cluster Therapy (ACT) and Induced Immune Response
Sripalan, Gopana (Master thesis, 2021)Abstract will be available on 2024-08-01 -
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Peer reviewed; Journal article, 2021)We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl ... -
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Peer reviewed, 2018)The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary ... -
Characterization of immune cell populations in syngeneic murine tumor models
Snipstad, Sofie; Bremnes, Frida; Haugum, Mats Dehli; Sulheim, Einar (Peer reviewed; Journal article, 2023)Immunocompetent murine models are important tools for preclinical evaluation of immunotherapies. Here, six different immunocompetent tumor models based on four different cell lines were characterized, including metastatic ... -
Characterization of protein corona on poly(alkyl cyanoacrylate) nanoparticles in human plasma
Kjøsnes, Heidi Rørvik (Master thesis, 2020)Nanopartikler kan brukes som spesiallagde fremkomstmidler for forbedret medisinlevering. De kan brukes i behandling av ulike sykdommer og lidelser, inkludert kreft. Ulike materialer kan brukes i arkitekturen til nanopartiklene. ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles
Snipstad, Sofie; Westrøm, Sara; Mørch, Ýrr Asbjørg; Afadzi, Mercy; Åslund, Andreas; Davies, Catharina De Lange (Journal article; Peer reviewed, 2014)Encapsulation of drugs in nanoparticles can enhance the accumulation of drugs in tumours, reduce toxicity toward healthy tissue, and improve pharmacokinetics compared to administration of free drug. To achieve efficient ... -
Effect of Ultrasound and Microbubble Treatment on Tumor Vasculature and Liposomal Uptake in Murine Cancer Models
Kastellet, Andrea Berge (Master thesis, 2023)Hensikt: Målet med denne oppgaven var å undersøke om ultralyd- og mikroboblebehandling (USMB) kan forbedre levering av nanomedisin i murine tumormodeller. Nærmere bestemt ble effekten av USMB på tumorperfusjon og på opptak ... -
Effect of Ultrasound and Microbubbles on Vasculature and Extracellular Matrix Components in Murine Breast Cancer Tumors
Årseth, Charlotte (Master thesis, 2022)Suksessfull kreftbehandling har i mange år vært hindret av utilstrekkelig leveranse av medisiner. En tilnærming til dette problemet er å bruke ultralyd og mikrobobler (USMB) for å overkomme problemer relatert til vaskulatur ... -
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Yemane, Petros Tesfamichael; Åslund, Andreas K. O.; Snipstad, Sofie; Bjørkøy, Astrid; Grendstad, Kristin; Berg, Sigrid; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Hansen, Rune; Davies, Catharina de Lange (Journal article; Peer reviewed, 2019)Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect ... -
Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT)
Åslund, Karl Olof Andreas; Snipstad, Sofie; Healey, Andrew J.; Kvåle, Svein; Torp, Sverre Helge; Sontum, Per C.; Davies, Ruth Catharina de Lange; van Wamel, Annemieke (Journal article; Peer reviewed, 2017)The blood-brain barrier (BBB) is a major obstacle in drug delivery for diseases of the brain, and today there is no standardized route to surpass it. One technique to locally and transiently disrupt the BBB, is focused ... -
Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery
Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Peer reviewed; Journal article, 2022)The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ... -
High-Speed Optical Characterization of Protein-and-Nanoparticle–Stabilized Microbubbles for Ultrasound-Triggered Drug Release
Nawijn, Charlotte; Segers, Tim; Lajoinie, Guillaume; Berg, Sigrid; Snipstad, Sofie; Davies, Catharina de Lange; Versluis, Michel (Journal article; Peer reviewed, 2024)Objective: Ultrasound-triggered bubble-mediated local drug delivery has shown potential to increase therapeutic efficacy and reduce systemic side effects, by loading drugs into the microbubble shell and triggering delivery ... -
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach
Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick (Peer reviewed; Journal article, 2022)Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most ... -
Imaging microstreaming surrounding oscillating microbubbles in ultrasound mediated drug delivery
Larsen, Adrian (Master thesis, 2024)Denne avhandlingen utforsker avbildning og kvantifisering av mikrostrømning indusert av stabilt kaviterende mikrobobler eksponert av 1M Hz ultralyd i selvproduserte mikrokanaler, laget ved hjelp av fotolitografi-teknikker. ... -
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Labeling nanoparticles: Dye leakage and altered cellular uptake
Snipstad, Sofie; Hak, Sjoerd; Baghirov, Habib; Sulheim, Einar; Mørch, Ýrr Asbjørg; Lelu, Sylvie; von Haartman, Eva; Bäck, Marcus; Nilsson, Peter R; Klymchenko, Andrey S; Davies, Ruth Catharina de Lange; Åslund, Andreas (Journal article, 2016)In vitro and in vivo behavior of nanoparticles (NPs) is often studied by tracing the NPs with fluorescent dyes. This requires stable incorporation of dyes within the NPs, as dye leakage may give a wrong interpretation of ... -
Mechanisms for delivery of hydrophobic drugs from polymeric nanoparticles to cancer cells
Snipstad, Sofie (Master thesis, 2013)Encapsulation of drugs in nanoparticles could facilitate the accumulation of drugs in the tumor leading to less side effects and improved efficacy of the drug compared to conventional non-specific treatment interventions. ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...