Browsing NTNU Open by Author "Sandvik, Arne Kristian"
Now showing items 1-20 of 31
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BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Rustad, Even Holth; Dai, Hong Yan; Hov, Håkon; Coward, Eivind; Beisvag, Vidar; Myklebost, Ola; Hovig, Eivind; Nakken, Sigve; Vodak, Daniel; Meza-Zepeda, Leonardo A.; Sandvik, Arne Kristian; Wader, Karin Fahl; Misund, Kristine; Sundan, Anders; Aarset, Harald; Waage, Anders (Journal article; Peer reviewed, 2015)In this study, we analyzed the prevalence and clone size of BRAF V600E mutation in 209 patients with multiple myeloma and related the results to clinical phenotype, response and survival. Biopsies were screened for BRAF ... -
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2018)The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria. The present study ... -
Contributions of the EMERALD project to assessing and improving microarray data quality
Beisvag, Vidar; Kauffmann, Audrey; Malone, James; Foy, Carole; Salit, Marc; Schimmel, H; Bongcam-Rudloff, Eric; Landegren, Ulf; Parkinson, Helen; Huber, Wolfgang; Brazma, Alvis; Sandvik, Arne Kristian; Kuiper, Martin (Journal article; Peer reviewed, 2011)While minimum information about a microarray experiment (MIAME) standards have helped to increase the value of the microarray data deposited into public databases like ArrayExpress and Gene Expression Omnibus (GEO), limited ... -
Differences between the HT29 and HT29- MTX epithelial cell lines - An analysis of gene expression data
Skovdahl, Helene Kolstad (Master thesis, 2016)Introduction: Epithelial cancerous cell lines are used in a wide variety of research because of the unique possibility to study isolated cellular mechanisms in detail. This can be used for wider understanding of pathological ... -
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article, 2013)We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD), in an extensive material of ulcerative colitis (UC) and Crohn`s disease (CD). The chemokine CXCL10 and its receptor ... -
Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Bruland, Torunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are ... -
Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells
Mjønes, Patricia; Nordrum, Ivar Skjåk; Sørdal, Øystein Finset; Sagatun, Liv; Fossmark, Reidar; Sandvik, Arne Kristian; Waldum, Helge (Journal article, 2017)Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In ... -
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Anti-microbial peptides might influence the pathogenesis and course of inflammatory bowel disease (IBD). We sought to clarify the role of the anti-microbial glycoprotein lipocalin 2 (LCN2) in the colon by determining its ... -
Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease
Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2017)Background and Aim Accurate, noninvasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin 2, is expressed in inflamed ... -
Forekomst av kolorektalkreft i en 5-års periode etter negativ colonoscopi, eller etter påvist adenomatøs polypp
Vallner, Sindre (Master thesis, 2013)Introduksjon: Norge har i dag den høyeste forekomsten av CRC i Norden. Insidensen av CRC har i mange tiår vært økende, men tall fra det siste tiåret viser stabilisering. Gullstandarden for å diagnostisere CRC og premaligne ... -
Gammadelta T cells in Crohn's disease: a new player in the disease pathogenesis?
catalan-Serra, Ignacio; Sandvik, Arne Kristian; Bruland, Torunn; Andreu-Ballester, Juan Carlos (Journal article; Peer reviewed, 2017)Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. An altered immune response to commensal intestinal bacteria takes place in genetically predisposed individuals, resulting ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis
Bruland, Torunn; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ... -
Immunoregulatory roles of chemokines and epithelium in inflammatory bowel disease - CCL20 in mucosa, human colonoids and peripheral blood mononuclear cells
Skovdahl, Helene Kolstad (Doctoral theses at NTNU;2020:382, Doctoral thesis, 2020)Inflammatory bowel diseases (IBD) are characterized by chronic inflammation in the intestinal tract, which leads to substantial cost for the individual and for society. The pathogenesis is described as an inflammation ... -
Inflammatory bowel disease
Vatn, Morten H; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Scandinavian researchers have contributed to the present understanding of inflammatory bowel disease (IBD). Important epidemiological data and family risk factors have been reported from all the Nordic countries, original ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
Intestinal epithelial ISG15 interactions with the immune system
Walaas, Gunnar Andreas (Master thesis, 2022)Introduksjon Inflammatorisk tarmsykdom (IBD) er en tilstand med kronisk inflammasjon i gastrointestinal traktus som utgjøres av sykdommene Crohns sykdom og ulcerøs kolitt. Det finnes ingen kur for IBD, men behandlingen er ... -
Microbiota in inflammatory bowel disease
Olaisen, Maya (Doctoral theses at NTNU;2021:86, Doctoral thesis, 2021) -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ...