Blar i NTNU Open på forfatter "Sæterstad, Siri"
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Characterization of a Paxx Knockout Mouse Model - Growth and immune system development in mice deficient of DNA repair factor PAXX
Sæterstad, Siri (Master thesis, 2018)Non-Homologous End-Joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in higher eukaryotes, functional throughout the cell cycle. NHEJ involves a variety of proteins; some are essential, whereas others ... -
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ... -
Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Robust DNA repair in PAXX-deficient mammalian cells
Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ... -
Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
Castañeda-Zegarra, Sergio; Xing, Mengtan; Gago-Fuentes, Raquel; Sæterstad, Siri; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ...