Blar i NTNU Open på forfatter "Ottestad, Anine Larsen"
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Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ... -
Assessment of Two Commercial Comprehensive Gene Panels for Personalized Cancer Treatment
Ottestad, Anine Larsen; Huang, Mo; Emdal, Elisabeth Fritzke; Mjelle, Robin; Skarpeteig, Veronica; Dai, Hong Yan (Peer reviewed; Journal article, 2023)(1) Background: Analysis of tumor DNA by next-generation sequencing (NGS) plays various roles in the classification and management of cancer. This study aimed to assess the performance of two similar and large, comprehensive ... -
Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
Ottestad, Anine Larsen; Johansen, Håkon; Halvorsen, Tarje Onsøien; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2023)Background The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic ... -
Associations between tumor mutations in cfDNA and survival in non-small cell lung cancer
Ottestad, Anine Larsen; Hong, Yan Dai; Halvorsen, Tarje Onsøien; Emdal, Elisabeth Fritzke; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Introduction: Studies have indicated that detection of mutated KRAS or EGFR in circulating tumor DNA (ctDNA) from pre-treatment plasma samples is a negative prognostic factor for non-small cell lung cancer (NSCLC) pa-tients. ... -
Challenges in implementing circulating tumor DNA analyses in lung cancer research
Ottestad, Anine Larsen (Doctoral theses at NTNU;2023:327, Doctoral thesis, 2023)Lung cancer is the leading cause of cancer-related deaths worldwide, including Norway. This study focused on non-small cell lung cancer (NSCLC), the most common subtype, and aimed to enhance the classification of NSCLC ... -
Fragmentation assessment of FFPE DNA helps in evaluating NGS library complexity and interpretation of NGS results
Ottestad, Anine Larsen; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Dai, Hong Yan (Journal article; Peer reviewed, 2022) -
The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study
Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Berg, Thomas; Halvorsen, Tarje Onsøien; Ottestad, Anine Larsen; Lund-Iversen, Marius; Brustugun, Odd; Førde, Dagny; Paulsen, Erna-Elise; Donnem, Tom; Andersen, Sigve; Grønberg, Bjørn Henning; Richardsen, Elin (Peer reviewed; Journal article, 2021)Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ... -
Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy
Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Dale, Vibeke Grotnes; Richardsen, Elin; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantication of nucleic acid sequences. We used absolute quantication of mutated v-Ki-ras2 Kirsten rat sarcoma viral oncogene ... -
The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients
Ottestad, Anine Larsen; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Skorpen, Frank; Dai, Hong Yan (Journal article; Peer reviewed, 2019)Studies have indicated that detection of circulating tumor DNA (ctDNA) prior to treatment is a negative prognostic marker in non-small cell lung cancer (NSCLC). ctDNA is currently identified by detection of tumor mutations. ...