• 150 Years of the Mass Action Law 

      Voit, Eberhard; Martens, Harald; Omholt, Stig William (Journal article; Peer reviewed, 2015)
      This year we celebrate the 150th anniversary of the law of mass action. This law is often assumed to have been “there” forever, but it has its own history, background, and a definite starting point. The law has had an ...
    • A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss) 

      Kahn, Uniza Wahid; Øverli, Øyvind; Hinkle, Patricia M.; Pasha, Farhan Ahmad; Johansen, Ida Beitnes; Berget, Ingunn; Silva, Patricia; Kittilsen, Silje; Höglund, Erik; Omholt, Stig William; Våge, Dag Inge (Journal article; Peer reviewed, 2016)
      In many vertebrate species visible melanin-based pigmentation patterns correlate with high stress- and disease-resistance, but proximate mechanisms for this trait association remain enigmatic. Here we show that a missense ...
    • Concerted Evolution of Life Stage Performances Signals Recent Selection on Yeast Nitrogen Use 

      Ibstedt, Sebastian; Stenberg, Simon; Bages, Sara; Gjuvsland, Arne Bjørke; Salinas, Francisco; Kourtchenko, Olga; Samy, Jeevan K.A.; Blomberg, Anders; Omholt, Stig William; Liti, Gianni; Beltran, Gemma; Warringer, Jonas (Journal article; Peer reviewed, 2015)
      Exposing natural selection driving phenotypic and genotypic adaptive differentiation is an extraordinary challenge. Given that an organism’s life stages are exposed to the same environmental variations, we reasoned that ...
    • Disentangling genetic and epigenetic determinants of ultrafast adaptation 

      Gjuvsland, Arne Bjørke; Zörgö, Enikö Beatrix; Antony Samy, Jeevan Karloss; Stenberg, Simon; Demirsoy, Ibrahim H; Roque, Francisco; Maciaszczyk-Dziubinska, Ewa; Migocka, Magdalena; Alonso-Perez, Elisa; Zackrisson, Martin; Wysocki, Robert; Tamas, Markus J; Jonassen, Inge; Omholt, Stig William; Warringer, Jonas (Journal article; Peer reviewed, 2016)
      A major rationale for the advocacy of epigenetically mediated adaptive responses is that they facilitate faster adaptation to environmental challenges. This motivated us to develop a theoretical–experimental framework for ...
    • Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture 

      Macqueen, Daniel J.; Primmer, Craig R.; Houston, Ross D.; Nowak, Barbara F.; Bernatchez, Louis; Bergseth, Steinar; Davidson, William S.; Gallardo-Escárate, Cristian; Goldammer, Tom; Guiguen, Yann; Iturra, Patricia; Kijas, James W.; Koop, Ben F.; Lien, Sigbjørn; Maass, Alejandro; Martin, Samuel A. M.; McGinnity, Philip; Montecino, Martin; Naish, Kerry; Nichols, Krista M.; Ólafsson, Kristinn; Omholt, Stig William; Palti, Yniv; Plastow, Graham S.; Rexroad, Caird E. 3rd; Rise, Matthew L.; Ritchie, Rachael J.; Sandve, Simen Rød; Schulte, Patricia M.; Tello, Alfredo; Vidal, Rodrigo; Vik, Jon Olav; Wargelius, Anna; Yáñez, José Manuel (Journal article; Peer reviewed, 2017)
      We describe an emerging initiative - the ‘Functional Annotation of All Salmonid Genomes’ (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ...
    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow 

      Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)
      The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...
    • Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale 

      Zackrisson, Martin; Hallin, Johan; Ottoson, Lars-Göran; Dahl, Peter; Fernandez-Parada, Esteban; Landström, Erik; Fernandez-Ricaud, Luciano; Kaferle, Petra; Skyman, Andreas; Stenberg, Simon; Omholt, Stig William; Petrovic, Uros; Warringer, Jonas; Blomberg, Anders (Journal article; Peer reviewed, 2016)
      The capacity to map traits over large cohorts of individuals-phenomics-lags far behind the explosive development in genomics. For microbes, the estimation of growth is the key phenotype because of its link to fitness. We ...
    • The Atlantic salmon genome provides insights into rediploidization 

      Lien, Sigbjørn; Koop, Ben F; Sandve, Simen Rød; Miller, Jason R.; Kent, Matthew Peter; Nome, Torfinn; Hvidsten, Torgeir Rhoden; Leong, Jong; Minkley, David R.; Zimin, Aleksey; Grammes, Fabian; Grove, Harald; Gjuvsland, Arne Bjørke; Walenz, Brian; Hermansen, Russell A.; von Schalburg, Kristian R.; Rondeau, Eric; Genova, Alex Di; Antony Samy, Jeevan Karloss; Vik, Jon Olav; Vigeland, Magnus Dehli; Caler, Lis; Grimholt, Unni; Jentoft, Sissel; Våge, Dag Inge; de Jong, Pieter J.; Moen, Thomas; Baranski, Matthew; Palti, Yniv; Smith, Douglas W.; Yorke, James A.; Nederbragt, Alexander J.; Tooming-Klunderud, Ave; Jakobsen, Kjetill Sigurd; Jiang, Xuanting; Fan, Dingding; Hu, Yan; Liberles, David A.; Vidal, Rodrigo; Iturra, Patricia; Jones, Steven J.M.; Jonassen, Inge; Maass, Alejandro; Omholt, Stig William; Davidson, William S (Journal article; Peer reviewed, 2016)
      The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate ...