• Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF 

      Nymo, Stig Haugset; Niyonzima, Nathalie; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2014)
      Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. ...
    • Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis 

      Pilely, Katrine; Rosbjerg, Anne; Genster, Ninette; Gál, Peter; Pál, Gábor; Halvorsen, Bente; Holm, Sverre; Aukrust, Pål; Bakke, Siril Skaret; Sporsheim, Bjørnar; Nervik, Ingunn; Niyonzima, Nathalie; Bartels, Emil D.; Stahl, Gregory L.; Mollnes, Tom Eirik; Espevik, Terje; Garred, Peter (Journal article, 2016)
      Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown. We hypothesized ...
    • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis 

      Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)
      Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ...
    • Complement activation by cholesterol crystals triggers a subsequent cytokine response 

      Niyonzima, Nathalie; Halvorsen, Bente; Sporsheim, Bjørnar; Garred, Peter; Aukrust, Pål; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)
      In the host a diverse collection of endogenous danger signals is constantly generated consisting of waste material as protein aggregates or crystalline materials that are recognized and handled by soluble pattern recognition ...
    • Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism 

      Arbore, Giuseppina; West, Erin; Rahman, Jubayer; Le Friec, Gaelle; Niyonzima, Nathalie; Mehdi, Pirooznia; Ilker, Tunc; Polychronis, Pavlidis; Nicholas, Powell; Li, Yuesheng; Liu, Poching; Servais, Aude; Couzi, Lionel; Fremeaux-Bacchi, Veronique; Placais, Leo; Ferraro, Alastair; Walsh, Patrick R.; Kavanagh, David; Afzali, Behdad; Lavender, Paul; Lachmann, Helen J.; Kemper, Claudia (Journal article; Peer reviewed, 2018)
      The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ ...
    • Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation 

      Niyonzima, Nathalie; Samstad, Eivind; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Rokstad, Anne Mari; Wright, Samuel; Damås, Jan Kristian; Mollnes, Tom Eirik; Latz, Eicke; Espevik, Terje (Journal article; Peer reviewed, 2015)
      Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ...
    • Role of the complement system in inflammatory responses to cholesterol crystals 

      Niyonzima, Nathalie (Doctoral thesis at NTNU;2015:78, Doctoral thesis, 2015)
      Komplementsystemets rolle i kolesterolkrystall induserte inflammatoriske responser Hjerte- og karsykdommer forårsaker globalt 17,3 millioner dødsfall pr. år og var med dette den ledende dødsårsaken i 2008. De vanligste ...