• A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation 

      Ito, Hiroshi; Zhang, Sheng Jia; Witter, Menno; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2015)
      Spatial navigation requires information about the relationship between current and future positions. The activity of hippocampal neurons appears to reflect such a relationship, representing not only instantaneous position ...
    • Coherence among Head Direction Cells before Eye Opening in Rat Pups 

      Bjerknes, Tale L.; Langston, Rosamund Fay; Kruge, Ingvild Ulsaker; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Mammalian navigation is thought to depend on an internal map of space consisting of functionally specialized cells in the hippocampus and the surrounding parahippocampal cortices [1–7]. Basic properties of this map are ...
    • Coordination of entorhinal-hippocampal ensemble activity during associative learning 

      Igarashi, Kei M; Lu, Li; Colgin, Laura Lee; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)
      Accumulating evidence points to cortical oscillations as a mechanism for mediating interactions among functionally specialized neurons in distributed brain circuits1, 2, 3, 4, 5, 6. A brain function that may use such ...
    • Dissociation between postrhinal cortex and downstream parahippocampal regions in the representation of egocentric boundaries 

      Gofman, Xenia; Tocker, Gilad; Weiss, Shahaf; Boccara, Charlotte N; Lu, Li; Moser, May-Britt; Moser, Edvard Ingjald; Morris, Genela; Derdikman, Dori Moshe (Journal article; Peer reviewed, 2019)
      Navigation requires the integration of many sensory inputs to form a multi-modal cognitive map of the environment, which is believed to be implemented in the hippocampal region by spatially tuned cells [1, 2, 3, 4, 5, 6, ...
    • During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost 

      Almog, Nava; Tocker, Gilad; Bonnevie, Tora; Moser, Edvard Ingjald; Moser, May-Britt; Derdikman, Dori Moshe (Journal article; Peer reviewed, 2019)
      The grid cell network in the medial entorhinal cortex (MEC) has been subject to thorough testing and analysis, and many theories for their formation have been suggested. To test some of these theories, we re-analyzed data ...
    • Entorhinal fast-spiking speed cells project to the hippocampus 

      Ye, Jing; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)
      The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in ...
    • Functional diversity along the transverse axis of hippocampal area CA1 

      Igarashi, Kei M; Ito, Hiroshi; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Decades of neuroscience research have shed lights on the hippocampus as a key structure for the formation of episodic memory. The hippocampus is divided into distinct subfields – CA1, CA2 and CA3. Whereas accumulating ...
    • Functional organization of the hippocampal longitudinal axis 

      Strange, B; Witter, Menno; Lein, Ed S.; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)
      The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) ...
    • Functional properties of stellate cells in medial entorhinal cortex layer II 

      Rowland, David Clayton; Obenhaus, Horst-Andreas; Skytøen, Emilie; Zhang, Qiangwei; Kentros, Clifford; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2018)
      Layer II of the medial entorhinal cortex (MEC) contains two principal cell types: pyramidal cells and stellate cells. Accumulating evidence suggests that these two cell types have distinct molecular profiles, physiological ...
    • Grid cells and cortical representation 

      Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and ...
    • Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex 

      Miao, Chenglin; Cao, Qichen; Ito, Hiroshi; Yamahachi, Homare; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2015)
      Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as ...
    • Integrating time from experience in the lateral entorhinal cortex 

      Moser, Edvard Ingjald; Tsao, Albert; Sugar, Jørgen; Wang, Cheng-Cheng; Moser, May-Britt; Knierim, James (Journal article; Peer reviewed, 2018)
      The encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal–entorhinal circuits is unclear. Here we show in freely foraging rats that temporal ...
    • Integration of grid maps in merged environments 

      Wernle, Tanja; Waaga, Torgeir; Mørreaunet, Maria; Treves, Alessandro; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)
      Natural environments are represented by local maps of grid cells and place cells that are stitched together. The manner by which transitions between map fragments are generated is unknown. We recorded grid cells while rats ...
    • Navigating cognition: Spatial codes for human thinking 

      Bellmund, Jacob Lukas Sarid; Gärdenfors, Peter; Moser, Edvard Ingjald; Doeller, Christian Fritz Andreas (Journal article; Peer reviewed, 2018)
      Ever since Tolman's proposal of cognitive maps in the 1940s, the question of how spatial representations support flexible behavior has been a contentious topic. Bellmund et al. review and combine concepts from cognitive ...
    • Parvalbumin and Somatostatin Interneurons Control Different Space-Coding Networks in the Medial Entorhinal Cortex 

      Miao, Chenglin; Cao, Qichen; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2017)
      The medial entorhinal cortex (MEC) contains several discrete classes of GABAergic interneurons, but their specific contributions to spatial pattern formation in this area remain elusive. We employed a pharmacogenetic ...
    • Path integration in place cells of developing rats 

      Bjerknes, Tale Litlere; Dagslott, Nenitha; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2018)
      Place cells in the hippocampus and grid cells in the medial entorhinal cortex rely on self-motion information and path integration for spatially confined firing. Place cells can be observed in young rats as soon as they ...
    • Place cells in the hippocampus: Eleven maps for eleven rooms 

      Alme, Charlotte; Miao, Chenglin; Jezek, Karel; Treves, Alessandro; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      The contribution of hippocampal circuits to high-capacity episodic memory is often attributed to the large number of orthogonal activity patterns that may be stored in these networks. Evidence for high-capacity storage in ...
    • Place cells, grid cells, and memory 

      Moser, May-Britt; Rowland, David Clayton; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2015)
      The hippocampal system is critical for storage and retrieval of declarative memories, including memories for locations and events that take place at those locations. Spatial memories place high demands on capacity. Memories ...
    • Ready, steady, go! Development of spatial representations in the rat 

      Kruge, Ingvild Ulsaker (Doctoral theses at NTNU;2016:320, Doctoral thesis, 2016)
      In mice and men, the hippocampal region is the central brain network for declarative memory and dynamic representation of location. Hippocampal place cells and entorhinal grid cells use head direction, border and speed ...
    • Representation of geometric borders in the developing rat 

      Bjerknes, Tale Litlere; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Local space is represented by a number of functionally specific cell types, including place cells in the hippocampus and grid cells, head direction cells, and border cells in the medial entorhinal cortex (MEC). These cells ...