Browsing NTNU Open by Author "Moestue, Siver Andreas"
Now showing items 1-20 of 60
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18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients
Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Willoch, Frode; Størkersen, Øystein; Sandsmark, Elise; Moestue, Siver Andreas; Tessem, May-Britt; Halvorsen, Dag; Kjøbli, Eirik; Angelsen, Anders; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Objective To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. Methods High-risk prostate cancer patients (n=28) ... -
A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer.
Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ... -
Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: a correlation study between micro-CT angiography and DCE-MRI
Kim, Eugene; Cebulla, Jana; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016) -
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ... -
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer
Søgaard, Caroline Danielsen; Moestue, Siver Andreas; Rye, Morten Beck; Kim, Jana; Nepal, Anala; Liabakk, Nina-Beate; Bachke, Siri; Bathen, Tone Frost; Otterlei, Marit; Hill, Deborah Katherine (Journal article; Peer reviewed, 2018)Docetaxel is the chemotherapeutic choice for metastatic hormone-refractory prostate cancer, however, it only marginally improves the survival rate. The purpose of the present study was to examine if a peptide ... -
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Karvelsson, Sigurdur; Wang, Qiong; Hilmarsdòttir, Bylgja; Sigurdsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Peer reviewed, 2021) -
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia
Pettersen, Kristine; Andersen, Sonja Benedikte; van der Veen, Anna; Nonstad, Unni; Hatakeyema, Shinji; Lambert, Christian; Lach-Trifilieff, Estelle; Moestue, Siver Andreas; Kim, Jana; Grønberg, Bjørn Henning; Schilb, Alain; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2019)Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the ... -
Bestemmelse av fosfolipidnivåer i EGF-behandlede brystkreftceller dyrket in vitro med hjelp av MALDI-MSI
With Andreassen, Veronica (Master thesis, 2022)Brystkreft er i dag den vanligste kreftrelaterte dødsårsaken blant kvinner i verden. Til tross for gode prognoser for de fleste molekylære undergruppene av brystkreft, er det også noen grupper som har svært dårlig prognose. ... -
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Peer reviewed; Journal article, 2021)We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl ... -
Biomarker discovery using NMR based metabolomics of tissue
Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ... -
Bruk av piperacillin/tazobaktam ved behandling av infeksjoner i abdomen - Kan intervensjoner bidra til å optimalisere forskrivningen?
Gustavsen, Ingrid Ressem (Master thesis, 2022)Introduksjon: Antibiotikaresistens er en trussel mot folkehelsen. Effektive tiltak for å bremse utviklingen er viktig for å kunne ha effektiv antibiotikabehandling også i fremtiden. De nasjonale retningslinjene for ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
Pallasaho, Satu; Gondane, Aishwarya; Kuivalainen, Anni; Girmay, Samuel; Moestue, Siver Andreas; Loda, Massimo; Itkonen, Harri (Journal article; Peer reviewed, 2022) -
Characterization of protein corona on poly(alkyl cyanoacrylate) nanoparticles in human plasma
Kjøsnes, Heidi Rørvik (Master thesis, 2020)Nanopartikler kan brukes som spesiallagde fremkomstmidler for forbedret medisinlevering. De kan brukes i behandling av ulike sykdommer og lidelser, inkludert kreft. Ulike materialer kan brukes i arkitekturen til nanopartiklene. ... -
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA
Frahm, Anne; Hill, Deborah Katherine; Katsikis, Sotirios; Andreassen, Trygve; Ardenkjær-Larsen, Jan Henrik; Bathen, Tone Frost; Moestue, Siver Andreas; Jensen, Pernille Rose; Lerche, Mathilde (Peer reviewed; Journal article, 2021)Hyperpolarized 13C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue ... -
Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer
Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ... -
Cytosolic phospholipase A2 alpha in aggressive breast cancer: Linking inflammation, angiogenesis, and metastasis
Tunset, Hanna Maja (Doctoral theses at NTNU;2018:340, Doctoral thesis, 2018) -
Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ... -
Detection and differentiation of breast cancer sub-types using a cPLA2a activatable fluorophore
Chiorazzo, MG; Tunset, Hanna Maja; Popov, AV; Johansen, Berit; Moestue, Siver Andreas; Delikatny, EJ (Journal article; Peer reviewed, 2019)Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we ... -
Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen
Barkovskaya, Anna; Goodwin, Craig; Seip, Kotryna; Hilmarsdòttir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eirikur; Der, Channing J; Moestue, Siver Andreas; Guðjónsson, Þórarinn; Mælandsmo, Gunhild Mari; Prasmickaite, Lina (Peer reviewed; Journal article, 2021)Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast ...