• Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre; Qvigstad, Elisabeth; Richardsen, Kåre Rønn; Waage, Christin; Sletner, Line; Jenum, Anne Karen; Prasad, Rashmi B.; Groop, Leif C.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Journal article; Peer reviewed, 2021)
      Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) ...
    • Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line; Jenum, Anne Karen; Qvigstad, Elisabeth; Prasad, Rashmi B.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Peer reviewed; Journal article, 2023)
      Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, ...
    • Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth 

      Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen Øiseth; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero Olavi; Morgen, Camilla S.; Nøhr, Ellen Aagaard; Nyegaard, Mette; Palmer, Colin N. A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W. V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per Minor; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Zhang, Ge; Hivert, Marie-France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2023)
      A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ...
    • Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans 

      Sommer, Christine; Vangberg, Kjersti G.; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre; Høgestøl, Ingvild Kristine; Sletner, Line; Jenum, Anne Karen; Drevon, Christian A.; Gulseth, Hanne Løvdal; Birkeland, Kåre Inge (Peer reviewed; Journal article, 2022)
      Context Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown. Objective This work aimed to test ...
    • Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk 

      D’Urso, Shannon; Arumugam, Pooja; Weider, Therese; Hwang, Liang-Dar; Bond, Tom A.; Kemp, John P.; Warrington, Nicole Maree; Evans, David M.; O’Mara, Tracy A.; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2022)
      Background Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships ...
    • Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth 

      Brito Nunes, Caroline; Huang, Peiyuan; Wang, Geng; Lundberg, Mischa; D'Urso, Shannon; Wootton, Robyn E; Borges, Maria Carolina; Lawlor, Deborah A.; Warrington, Nicole Maree; Evans, David M.; Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2023)
      Background Coffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee ...
    • Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes 

      Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P.; Allard, Catherine; Beaumont, Robin N.; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H.; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur; Hummel, Sandra; Hussain, Akhtar; Kajantie, Eero Olavi; Keikkala, Elina; Khamis, Amna; Lahti, Jari; Lekva, Tove; Mustaniemi, Sanna; Sommer, Christine; Tagoma, Aili; Tzala, Evangelia; Uibo, Raivo; Vääräsmäki, Marja; Villa, Pia M.; Birkeland, Kåre Inge; Bouchard, Luigi; Duijn, Cornelia M.; Finer, Sarah; Groop, Leif; Hämäläinen, Esa; Hayes, Geoffrey M.; Hitman, Graham A.; Jang, Hak C.; Järvelin, Marjo-Riitta; Jenum, Anne Karen; Laivuori, Hannele; Ma, Ronald C.; Melander, Olle; Oken, Emily; Park, Kyong Soo; Perron, Patrice; Prasad, Rashmi B.; Qvigstad, Elisabeth; Sebert, Sylvain; Stefansson, Kari; Steinthorsdottir, Valgerdur; Tuomi, Tiinamaija; Hivert, Marie-France; Franks, Paul W.; McCarthy, Mark I.; Lindgren, Cecilia M.; Freathy, Rachel M.; Lawlor, Deborah A.; Morris, Andrew P.; Mägi, Reedik (Peer reviewed; Journal article, 2022)
      Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 ...
    • Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes 

      Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth; Evans, David M. (Peer reviewed; Journal article, 2022)
      Maternal genetic effects can be defined as the effect of a mother’s genotype on the phenotype of her offspring, independent of the offspring’s genotype. Maternal genetic effects can act via the intrauterine environment ...
    • Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study 

      Moen, Gunn-Helen Øiseth; Nivard, Michel; Bhatta, Laxmi; Warrington, Nicole Maree; Willer, Cristen; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M. (Peer reviewed; Journal article, 2022)
      The Barker Hypothesis posits that adverse intrauterine environments result in fetal growth restriction and increased risk of cardiometabolic disease through developmental compensations. Here we introduce a new statistical ...