Browsing NTNU Open by Author "Mjelle, Robin"
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Assessment of Two Commercial Comprehensive Gene Panels for Personalized Cancer Treatment
Ottestad, Anine Larsen; Huang, Mo; Emdal, Elisabeth Fritzke; Mjelle, Robin; Skarpeteig, Veronica; Dai, Hong Yan (Peer reviewed; Journal article, 2023)(1) Background: Analysis of tumor DNA by next-generation sequencing (NGS) plays various roles in the classification and management of cancer. This study aimed to assess the performance of two similar and large, comprehensive ... -
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Journal article; Peer reviewed, 2022) -
Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients
Mjelle, Robin; Dima, Simona O.; Bacalbasa, Nicolae; Chawla, Konika; Sorop, Andrei; Cucu, Dana; Herlea, Vlad; Sætrom, Pål; Popescu, Irinel (Journal article; Peer reviewed, 2019)Background The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to ... -
Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth
Konstantinidis, Ioannis; Anastasiadi, Dafni; Sætrom, Pål; Nedoluzhko, Artem; Mjelle, Robin; Podgorniak, Tomasz; Piferrer, Francesc; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2021)In vertebrates, the somatotropic axis comprising the pituitary gland, liver and muscle plays a major role in myogenesis. Its output in terms of muscle growth is highly affected by nutritional and environmental cues, and ... -
The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation
Nedoluzhko, Artem; Mjelle, Robin; Renström, Maria; Skjærven, Kaja H.; Piferrer, Francesc; Fernandes, Jorge M.O. (Journal article; Peer reviewed, 2021)DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear ... -
Fusobacterium nucleatum and the Epstein-Barr virus-encoded microRNA miR-BART10-3p in colorectal cancer - validating the role of the genes CSF2, CCL20, MAT2B and ELL2
Sognnes, Vibeke (Master thesis, 2020)Kreft i tykktarm- og endetarm, kolorektal kreft (CRC), er den tredje hyppigste diagnostiserte og den nest mest dødelige kreftformen i verden med over 1.8 millioner nye tilfeller og 800,000 nye dødsfall i 2018. Nyere forskning ... -
Identification of metastasis-associated microRNAs in serum from rectal cancer patients
Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ... -
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells
Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine; Standal, Therese (Peer reviewed; Journal article, 2023)Multiple myeloma (MM) is a hematological cancer characterized by accumulation of malignant plasma cells in the bone marrow. The patients are immune suppressed and suffer from recurrent and chronic infections. Interleukin-32 ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
Investigation of single cells in tumor tissue and microRNAs in serum of colorectal cancer patients
Kjemperud, Hanna Sofie (Master thesis, 2022)Kolorektal kreft er en sykdom som påvirker nesten 2 millioner mennesker hvert år, og omtrent 20% av pasientene blir diagnostisert ved avanserte kreftstadier hvor behandling har dårlig effekt, som følge av mangel på symptomer ... -
Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication
Konstantinidis, Ioannis; Sætrom, Pål; Mjelle, Robin; Nedoluzhko, Artem; Robledo, Diego; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2020)The historically recent domestication of fishes has been essential to meet the protein demands ofa growing human population. Selection for traits of interest during domestication is a complexprocess whose epigenetic basis ... -
MicroRNA as biomarkers in colorectal cancer
Sellæg, Kjersti (Master thesis, 2016)Colorectal cancer (CRC) is one of the worlds leading causes of cancer-related deaths in both men and women. Nearly 1.4 million new cases were reported in 2012 and over half of the cases ended in death. High mortality rates ... -
Multiple layers of gene regulation: the cell cycle, epigenetics and microRNAs
Mjelle, Robin (Doctoral thesis at NTNU;2015:73, Doctoral thesis, 2015) -
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Peer reviewed; Journal article, 2022)Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that proliferate in the bone marrow. miRNAs are promising biomarkers for risk stratification in MM and several miRNAs are shown to have ... -
Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
Mjelle, Robin; Sjursen, Wenche; Thommesen, Liv; Sætrom, Pål; Hofsli, Eva (Journal article; Peer reviewed, 2019)Background MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from ... -
Small RNAs are differentially expressed in autoimmune and non-autoimmune diabetes and controls
Sørgjerd, Elin Pettersen; Mjelle, Robin; Beisvag, Vidar; Flatberg, Arnar; Grill, Valdemar Erik Robert; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2022)Objective Diabetes is a heterogeneous disease and a precise diagnosis of diabetes subgroups is necessary to initiate proper early treatment and clinical management of the disease. Circulating small RNAs (sRNAs) are ... -
sMETASeq: combined profiling of microbiota and host small RNAs
Mjelle, Robin; Aass, Kristin Roseth; Sjursen, Wenche; Hofsli, Eva; Sætrom, Pål (Peer reviewed; Journal article, 2020)Understanding microbial communities' roles in human health and disease requires methods that accurately characterize the microbial composition and their activity and effects within human biological samples. We present ... -
The role of Fusobacterium nucleatum and the Epstein-Barr virus encoded EBV-miR-BART10-3p in colorectal cancer - focusing on the genes CXCL8, CSF2, SAP18 and CCND1
Jerud, Julie Tro (Master thesis, 2020)Kolorektal kreft er den tredje mest vanlige krefttypen i verden, og den nest ledende årsaken til dødsfall forårsaket av kreft for begge kjønn. Utviklingen av kolorektal kreft er en prosess som foregår gjennom flere trinn ...