• HIV infection of CD4+ T cells: New insights into innate sensing and host dependency factors 

      Meås, Hany Zakaria (Doctoral theses at NTNU;2018:261, Doctoral thesis, 2018)
      Despite decades of research and public health efforts, HIV/AIDS remains a major global health issue with more than 36 million people infected with the virus in 2016. Effective HIV treatment has enabled HIV infected patients ...
    • The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function 

      Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2020)
      CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ...
    • Sensing of HIV-1 by TLR8 activates human T cells and reverses latency 

      Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen (Journal article; Peer reviewed, 2020)
      During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental ...