• External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis 

      Snell, Kym I.E.; Allotey, John; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; Von Dadelszen, Peter; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony; Arenas Ramírez, Javier; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, Ahmet A.; Seed, Paul T.; Prefumo, Federico; da Silva Costa, Fabricio; Groen, Henk; Audibert, Francois; Masse, Jacques; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, Chie; Rumbold, Alice R.; Heinonen, Seppo; Askie, Lisa; Smits, Luc; Vinter, Christina; Magnus, Per; Eero, Kajantie; Villa, Pia M.; Jenum, Anne Karen; Andersen, Louise B.; Norman, Jane E.; Ohkuchi, Akihide; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala; Galindo, Alberto; Herraiz, Ignacio; Carbillon, Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Browne, Joyce L.; Moons, Karel G.M.; Riley, Richard D.; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published ...
    • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 

      Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda (Peer reviewed; Journal article, 2020)
      Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ...
    • Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene 

      Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)
      Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ...
    • Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: Data from the Norwegian HUNT2 study 

      Kvehaugen, Anne Stine; Melien, Øyvind; Holmen, Oddgeir; Laivuori, Hannele; Dechend, Ralf; Staff, Anne Cathrine (Journal article; Peer reviewed, 2014)
      Background Preeclampsia is associated with an increased risk of hypertension later in life. The regulator of G protein signaling 2 negatively regulates several vasoconstrictors. We recently demonstrated an association ...
    • InterPregGen: Genetic studies of pre-eclampsia in three continents 

      Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele (Journal article; Peer reviewed, 2014)
      Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and ...
    • Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis 

      Allotey, John; Snell, Kym I.E.; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; von Dadelszen, Peter; Dodds, Julie; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid S.; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony O.; Ramírez, Javier A.; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, AA; Seed, PT; Prefumo, F; da Silva Costa, F; Groen, H; Audibert, F; Masse, J; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, C; Rumbold, Alice R.; Heinonen, Seppo; Askie, LM; Smits, LJ; Vinter, CA; Magnus, Per; Kajantie, Eero Olavi; Villa, PM; Jenum, Anne Karen; Andersen, LB; Norman, JE; Ohkuchi, A; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala M.; Galindo, Alberto; Herraiz, Ignacio; Carbillon, , Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Teede, Helena J.; Browne, Joyce L; Moons, Karel G.M.; Riley, Richard D; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management. Objectives: To assess the performance of existing pre-eclampsia ...