• Exploring the viability of measuring zinc and prostate-specific antigen in urine as a diagnostic tool for prostate cancer 

      Nguyen, Thai Thanh (Master thesis, 2021)
      Bakgrunn: Nåværende metoder for å diagnostisere prostatakreft benytter seg av inngripende biopsier, som kan føre til komplikasjoner som infeksjon og død. Ikke-inngripende metoder benytter seg av PSA målinger, som ofte er ...
    • KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases 

      Bartels, Anne-Kathrin; Gottert, Sascha; Desel, Christine; Schäfer, Miriam; Krossa, Sebastian; Scheidig, Axel J.; Gotzinger, Joachim; Lorenzen, Inken (Journal article; Peer reviewed, 2019)
      Background/Aims: Endoplasmic reticulum (ER)-resident proteins with a C-terminal KDEL ER-retention sequence are captured in the Golgi apparatus by KDEL receptors (KDELRs). The binding of such proteins to these receptors ...
    • Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17 

      Krossa, Sebastian; Scheidig, Axel J.; Grötzinger, Joachim; Lorenzen, Inken (Journal article; Peer reviewed, 2018)
      A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active form ...
    • Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue 

      Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Peer reviewed, 2020)
      Levels of zinc, along with its mechanistically related metabolites citrateand aspartate, are widely reported as reduced in prostate cancer compared to healthytissue and are therefore pointed out as potential cancer biomarkers. ...
    • Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI 

      Andersen, Maria Karoline; Høiem, Therese Stork; Claes, Britt S.R.; Balluff, Benjamin; Marta, Martin-Lorenzo; Richardsen, Elin; Krossa, Sebastian; Bertilsson, Helena; Heeren, Ron M.A.; Rye, Morten Beck; Giskeødegård, Guro F.; Bathen, Tone Frost; Tessem, May-Britt (Peer reviewed; Journal article, 2021)
      Background Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ...