Blar i NTNU Open på forfatter "Klevjer, Marie"
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Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study
Nodeland, Markus; Klevjer, Marie; Sæther, Julie Caroline; Giskeødegård, Guro F.; Bathen, Tone Frost; Wisløff, Ulrik; Bye, Anja (Journal article; Peer reviewed, 2022) -
Circulating lipoprotein subfractions and their association with aerobic fitness level
Nodeland, Markus Edvardsen; Sæther, Julie Caroline; Klevjer, Marie (Master thesis, 2020)Kondisnivå, målt som maksimalt oksygenopptak (VO2max), er en sterk markør for hjertehelse. Basert på dette kan serum profiler fra friske individ med stor differanse i VO2max nivå brukes til å identifisere sirkulerende ... -
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human
Benegiamo, Giorgia; Bou Sleiman, Maroun; Wohlwend, Martin; Rodríguez-López, Sandra; Goeminne, Ludger J. E.; Laurila, Pirkka-Pekka; Klevjer, Marie; Salonen, Minna K.; Lahti, Jari; Jha, Pooja; Cogliati, Sara; Enriquez, José Antonio; Brumpton, Ben Michael; Bye, Anja; Eriksson, Johan G.; Auwerx, Johan (Peer reviewed; Journal article, 2022)Mitochondrial respiratory complexes form superassembled structures called supercomplexes. COX7A2L is a supercomplex-specific assembly factor in mammals, although its implication for supercomplex formation and cellular ... -
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study
Nordeidet, Ada Nilsen; Klevjer, Marie; Wisløff, Ulrik; Langaas, Mette; Bye, Anja (Journal article; Peer reviewed, 2023)Low cardiorespiratory fitness, measured as maximal oxygen uptake (V̇o2max), is associated with all-cause mortality and disease-specific morbidity and mortality and is estimated to have a large genetic component (∼60%). ... -
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease
Klevjer, Marie; Nordeidet, Ada Nilsen; Bye, Anja (Journal article; Peer reviewed, 2023)Endurance training is associated with increased cardiorespiratory fitness (CRF) and decreased risk of cardiovascular disease (CVD). However, a causal relationship between exercise, CRF, and CVD has not been confirmed. ... -
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
Klevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael; Bye, Anja (Peer reviewed; Journal article, 2022)Purpose Low cardiorespiratory fitness (CRF) is a major risk factor for cardiovascular disease (CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors. The genetic component of CRF, ... -
Identification of novel genetic variants associated with cardiorespiratory fitness
Bye, Anja; Klevjer, Marie; Ryeng, Einar; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe; Wisløff, Ulrik (Peer reviewed; Journal article, 2020)Introduction Low maximal oxygen uptake (VO2max) is a strong and independent risk factor for all-cause and cardiovascular disease (CVD) mortality. For other CVD risk factors, numerous genetic association studies have been ... -
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3
De Soysa, Ann Kristin Hjelle; Klevjer, Marie; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Journal article; Peer reviewed, 2019)Purpose The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity per se. Against this background, we investigated the impact of FTO allele ... -
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
Klevjer, Marie; Rasheed, Humaira; Romundstad, Pål Richard; Madssen, Erik; Brumpton, Ben Michael; Bye, Anja (Peer reviewed; Journal article, 2023)Aims A low resting heart rate (RHR) implies a more efficient heart function and a lower risk of cardiovascular disease. However, observational studies have reported a U-shaped association between RHR and atrial fibrillation ... -
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study
Sperstad, Sigri Bakken; Sæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Røsbjørgen, Ragnhild; Dalen, Håvard; Bye, Anja (Peer reviewed; Journal article, 2023)Background Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI. Aim We ... -
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease
Nordeidet, Ada Nilsen; Klevjer, Marie; Øvretveit, Karsten; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael; Bye, Anja (Journal article; Peer reviewed, 2024)Aims: Resting heart rate (RHR) is associated with cardiovascular disease (CVD) and mortality. This study aimed to identify genetic loci associated with RHR, develop a genome-wide polygenic risk score (PRS) for RHR, and ... -
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids
Sæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna; Gjære, Sigrid; Myhra, Marthe; Vesterbekkmo, Elisabeth Kleivhaug; Wiseth, Rune; Madssen, Erik; Bye, Anja (Peer reviewed; Journal article, 2022)Lipoprotein subfractions currently represent a new source of cardiovascular disease (CVD) risk markers that may provide more information than conventional lipid measures. We aimed to investigate whether lipoprotein ... -
Statistical modelling and analysis of energy expenditure among severely overweight
Klevjer, Marie (Master thesis, 2017)The purpose of this thesis was to investigate the relationship between the energy expenditure and the FTO genotype (Fat Mass And Obesity-Associated Protein) of 101 severely overweight persons. The statistical methods used ... -
Statistical modelling and analysis of energy expenditure among severely overweight
Klevjer, Marie (Master thesis, 2017)The purpose of this thesis was to investigate the relationship between the energy expenditure and the FTO genotype (Fat Mass And Obesity-Associated Protein) of 101 severely overweight persons. The statistical methods used ...