• Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response 

      Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)
      Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ...
    • Common nodes of virus–host interaction revealed through an integrated network analysis 

      Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...
    • Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling 

      Subbannayya, Yashwanth; Pinto, Sneha M.; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members ...
    • Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M 

      Hansen, Marianne Dore; Johnsen, Ingvild Bjellmo; Stiberg, Kim Andre Ha; Sherstova, Tatyana; Wakita, Takaji; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Meurs, Eliane F.; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2017)
      Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral replication complexes by remodeling host intracellular membranes to a membranous web. The precise composition of these replication complexes ...
    • Novel insights on human-virus interactions through genome-wide approaches 

      Bösl, Korbinian (Doctoral theses at NTNU;2019:113, Doctoral thesis, 2019)
      Virus er en viktig årsak til sykdom og død blant mennesker over hele verden. Symptomer påvirusinfeksjoner spenner fra lett forkjølelse til livstruende sykdomstilstand. Virale patogener som Human Immunodeficiency Virus ...
    • Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines 

      Lee, Seung-Eun; Song, JongKeon; Bösl, Korbinian; Müller, André C.; Vitko, Dijana; Bennett, Keiryn L.; Superti-Furga, Giulio; Pandey, Akhilesh; Kandasamy, Richard Kumaran; Kim, Min-Sik (Journal article, 2018)
      Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt ...
    • The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function 

      Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2020)
      CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ...
    • SLAMF1 is required for TLR4-mediated TRAM-TRIF dependent signaling in human macrophages 

      Yurchenko, Mariya; Skjesol, Astrid; Ryan, Liv; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Wang, Ninghai; Terhorst, Cox; Husebye, Harald; Espevik, Terje (Journal article; Peer reviewed, 2018)
      Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 ...
    • The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 

      Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Journal article; Peer reviewed, 2019)
      Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...