• Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis 

      Skjeflo, Espen Waage; Sagatun, Caroline; Dybwik, Knut; Aam, Sturla; Urving, Sven Haakon; Nunn, Miles A.; Fure, Hilde; Lau, Corinna; Brekke, Ole Lars; Huber-Lang, Markus; Espevik, Terje; Barratt-Due, Andreas; Nielsen, Erik Waage; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2015)
      Introduction Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of innate immunity recognition systems including complement and the Toll-like receptor family initiate this disproportionate ...
    • Complement in sepsis — when science meets clinics 

      Mollnes, Tom Eirik; Huber-Lang, Markus (Peer reviewed; Journal article, 2020)
      Sepsis as life‐threatening organ dysfunction caused by microorganisms represents a dreadful challenge for the immune system. The role of the complement system as major column of innate immunity has been extensively studied ...
    • A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 

      Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2021)
      Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ...
    • Hemorrhagic shock induces a rapid transcriptomic shift of the immune balance in leukocytes after experimental multiple injury 

      Debler, Lisa; Palmer, Annette; Braumüller, Sonja; Klohs, Bettina; Mollnes, Tom Eirik; Holzmann, Karlheinz; Huber-Lang, Markus; Halbgebauer, Rebecca (Peer reviewed; Journal article, 2021)
    • Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma 

      Wang, Bingduo; Wöhler, Aliona; Greven, Johannes; Salzmann, Rebekka J. S.; Keller, Cindy M.; Tertel, Tobias; Zhao, Qun; Mert, Ümit; Horst, Klemens; Lupu, Ludmila; Huber-Lang, Markus; van Griensven, Martijn; Mollnes, Tom Erik; Schaaf, Sebastian; Schwab, Robert; Strassburg, Christian P.; Schmidt-Wolf, Ingo G. H.; Giebel, Bernd; Hildebrand, Frank; Lukacs-Kornek, Veronika; Willms, Arnulf G.; Kornek, Miroslaw T. (Journal article; Peer reviewed, 2023)
      Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ...
    • Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma 

      Lupu, Ludmila; Horst, Klemens; Greven, Johannes; Mert, Ümit; Ludviksen, Judith K; Pettersen, Kristin; Lau, Corinna; Li, Yang; Palmer, Annette; Qin, Kang; Zhang, Xing; Mayer, Benjamin; van Griensven, Martijn; Huber-Lang, Markus; Hildebrand, Frank; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2022)
      Dysfunctional complement activation and Toll-like receptor signaling immediately after trauma are associated with development of trauma-induced coagulopathy and multiple organ dysfunction syndrome. We assessed the efficacy ...