Browsing NTNU Open by Author "Høydal, Morten"
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Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial
Smenes, Benedikte; Bækkerud, Fredrik Hjulstad; Slagsvold, Katrine Hordnes; Hassel, Erlend; Wohlwend, Martin; Pinho, Maria; Høydal, Morten; Wisløff, Ulrik; Rognmo, Øivind; Wahba, Alexander (Journal article; Peer reviewed, 2018)OBJECTIVES During open-heart surgery, the myocardium experiences ischaemia–reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia–reperfusion injury ... -
Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats
Ljones, Kristine; Ness, Henning Ofstad; Solvang-Garten, Karin; Gaustad, Svein Erik; Høydal, Morten (Journal article; Peer reviewed, 2017)Introduction: Recent data from long-distance endurance participants suggest that cardiac function is impaired after completion. Existing data further indicate that right ventricular function is more affected than left ... -
Catalyzing transcriptomics research in cardiovascular disease: The CardioRNA COST action CA17129
da Costa Gomes, Clarissa Pedrosa; Ágg, Bence; Andova, Andrejaana; Arslan, Serdal; Baker, Andrew; Barteková, Monika; Beis, Dimitris; Betsou, Fay; Wettinger, Stephanie Bezzina; Bugarski, Branko; Condorelli, Gianluigi; Silva, Gustavo Jose Justo; Danilin, Sabrina; de Gonzalo-Calvo, David; Buil, Alfonso; Carmo-Fonseca, Maria; Enguita, Francisco J.; Felekkis, Kyriacos; Ferdinandy, Peter; Gyöngyösi, Mariann; Hackl, Matthias; Karaduzovic-Hadziabdic, Kanita; Hellemans, Jan; Heymans, Stephane; Hlavackova, Markéta; Høydal, Morten; Jankovic, Aleksandra; Jusic, Amela; Kardassis, Dimitris; Kerkelä, Risto; Kuster, Gabriela M.; Lakkisto, Päivi; Leszek, Przemyslaw; Lustrek, Mitja; Maegdefessel, Lars; Martelli, Fabio; Novella, Susana; O’Brien, Timothy; Papaneophytou, Christos; Pedrazzini, Thierry; Pinet, Florence; Popescu, Octavian; Potočnjak, Ines; Robinson, Emma; Sasson, Shlomo; Scholz, Markus; Simionescu, Maya; Stoll, Monika; Varga, Zoltán V.; Vinciguerra, Manlio; Xuereb, Angela; Yilmaz, Mehmet Birhan; Emanueli, Costanza; Devaux, Yvan (Journal article; Peer reviewed, 2019)Cardiovascular disease (CVD) remains the leading cause of death worldwide and, despite continuous advances, better diagnostic and prognostic tools, as well as therapy, are needed. The human transcriptome, which is the set ... -
Comparison of left versus right atrial myocardium in patients with sinus rhythm or atrial fibrillation - an assessment of mitochondrial function and microRNA expression.
Slagsvold, Katrine Hordnes; Johnsen, Anne Berit; Rognmo, Øivind; Høydal, Morten; Wisløff, Ulrik; Wahba, Alexander (Journal article; Peer reviewed, 2014)Several of the cellular alterations involved in atrial fibrillation (AF) may be linked to mitochondrial function and altered microRNA (miR) expression. A majority of studies on human myocardium involve right atrial (RA) ... -
Effects of doxorubicin on cell death and the transcriptome in human AC16 cardiomyocytes
Lunde, Ingvild (Master thesis, 2022)Bakgrunn: Kreft og hjarte- og karsjukdom er leiande dødsårsaker i verda. Doxorubicin er mykje nytta som cellegift i kreftbehandling, men utvikling av kardiotoksisitet avgrensar bruken. Faktorar som bidreg til doxorubicin-indusert ... -
Effects of hypoxia/reoxygenation and miR-24-3p in human cardiomyocyte models
Tran, Anette (Master thesis, 2020)Background: Effective cardioprotective therapies targeting the reperfusion phase of ischemia/reperfusion (I/R) injury are lacking, which remain one of the top unmet clinical needs in cardiology. MicroRNAs (miRNAs) are a ... -
Effects of overexpressing NOR-1 on cell death and cell viability in human cardiomyocytes during doxorubicin-induced stress
Berg, Per-Christian (Master thesis, 2021)Koronar hjertesykdom er den ledende dødsårsaken i verden, karakterisert av redusert blodforsyning til hjertet. Ubehandlet kan dette føre til en fullstendig blokkering av koronararteriene, kjent som et hjerteinfarkt. ... -
Exogenous miR-451a prevents MMP-9 upregulation in cardiac hypertrophy
Wrobel, Aleksandra Zofia (Master thesis, 2016)Matrix metalloproteinase-9 (MMP-9) degrades extracellular matrix and is increased in several cardiac pathologies. Recently microRNA (miR)-451a has been found to inhibit the expression of MMP-9 in human malignancies. However, ... -
High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes
Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Høydal, Morten; Catalucci, Daniele; Stølen, Tomas (Journal article; Peer reviewed, 2019)UNIKARD (Project Number 217777/H10) -
Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure
Høydal, Morten; Karevold, Asbjørn; Garstad, Idar Kirkeby; Wiseth, Rune; Haaverstad, Rune; Stølen, Tomas; Contu, Riccardo; Condorelli, Gianluigi; Ellingsen, Øyvind; Smith, Godfrey L; Kemi, Ole J; Wisløff, Ulrik (Journal article; Peer reviewed, 2018)Aims Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end‐stage heart failure (HF). To address this limitation, we provide data on ... -
microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation.
Scrimgeour, Nathan Robert; Wrobel, Aleksandra Zofia; Pinho, Maria; Høydal, Morten (Peer reviewed; Journal article, 2019)Matrix metalloproteinases (MMP) are important for cardiac remodeling. Recently, microRNA (miR)-451a has been found to inhibit the expression of both MMP-2 and MMP-9 in human malignancies, but its role in cardiomyocytes has ... -
NOR-1 overexpression protects AC16 human cardiomyocytes against cellular stress responses occurring during hypoxia
Hansson, Åse Mari Larsen (Master thesis, 2021)Bakgrunn: Det er vist at trening kan beskytte hjertet mot skader forårsaket av iskemi/reperfusjon (IR), men de underliggende cellulære mekanismene bak denne beskyttende effekten er fortsatt ukjent. Et av proteinene som er ... -
Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Koch, Lauren G.; Britton, Steven L.; Wisløff, Ulrik; Stølen, Tomas; Esmaeili, Morteza (Journal article; Peer reviewed, 2018)Purpose Exercise training increases aerobic capacity and is beneficial for health, whereas low aerobic exercise capacity is a strong independent predictor of cardiovascular disease and premature death. The purpose of ... -
Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Koch, Lauren G.; Britton, Steven L.; Wisløff, Ulrik; Stølen, Tomas; Esmaeili, Morteza (Peer reviewed; Journal article, 2018)Purpose Exercise training increases aerobic capacity and is beneficial for health, whereas low aerobic exercise capacity is a strong independent predictor of cardiovascular disease and premature death. The purpose of the ... -
The effect of exercise training on myocardial and skeletal muscle metabolism by MR spectroscopy in rats with heart failure
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Stølen, Tomas; Esmaeili, Morteza (Journal article; Peer reviewed, 2019)he metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the ... -
The potential of cardiac troponins I and T, CK-MB and NT-proANP as biomarkers of cardiac stress in farmed Atlantic salmon (Salmo salar)
Westermann, Sunniva (Master thesis, 2022)Denne oppgaven sammenlignet nivåer av hjertesviktsmarkører i Atlantisk laks (Salmo salar) fra en merd på Frøya før og etter transport til et slakteri på Averøy. Hensikten var å fastslå om stress i forbindelse med trenging, ...