• A 5700 year-old human genome and oral microbiome from chewed birch pitch 

      Jensen, Theis Zetner Trolle; Niemann, Jonas; Iversen, Katrine Højholt; Fotakis, Anna K.; Gopalakrishnan, Shyam; Vågene, Åshild J; Pedersen, Mikkel Winther; Sinding, Mikkel-Holger S.; Ellegaard, Martin R; Allentoft, Morten E.; Lanigan, Liam T; Taurozzi, Alberto J; Nielsen, Sofie Holtsmark; Dee, Michael W; Mortensen, Martin; Christensen, Mads C; Sørensen, Søren; Collins, Matthew J; Gilbert, Marcus Thomas Pius; Sikora, Martin; Rasmussen, Simon; Schroeder, Hannes (Peer reviewed; Journal article, 2019)
      The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancienthuman genome and oral microbiome sequenced ...
    • An expanded mammal mitogenome dataset from Southeast Asia 

      Salleh, Faezah Mohd; Ramos-Madrigal, Jazmín; Peñaloza, Fernando; Liu, Shanlin; Sinding, Mikkel Holger Strander; Patel, Riddhi P.; Martins, Renata; Lenz, Dorina; Fickel, Jörns; Roos, Christian; Shamsir, Mohd Shahir; Azman, Mohammad Shahfiz; Lim, Burton K.; Rossiter, Stephen J.; Wilting, Andreas; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2017)
      Southeast (SE) Asia is 1 of the most biodiverse regions in the world, and it holds approximately 20% of all mammal species. Despite this, the majority of SE Asia's genetic diversity is still poorly characterized. The growing ...
    • An ‛Aukward’ tale: a genetic approach to discover the whereabouts of the last Great Auks 

      Thomas, Jessica E; Carvalho, Gary R.; Haile, James; Martin, Michael David; Castruita, Jose A. Samaniego; Niemann, Jonas; Sinding, Mikkel Holger Strander; Sandoval-Velasco, Marcela; Rawlence, Nicolas J.; Fuller, Errol; Fjeldså, Jon; Hofreiter, Michael; Stewart, John R; Gilbert, Marcus Thomas Pius; Knapp, Michael (Journal article; Peer reviewed, 2017)
      One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the ...
    • Ancient DNA reveals the timing and persistence of organellar genetic bottlenecks over 3,000 years of sunflower domestication and improvement 

      Wales, Nathan; Akman, Melis; Watson, Ray H B; Sánchez Barreiro, Fatima; Smith, Bruce D; Gremillion, Kristen J; Gilbert, Marcus Thomas Pius; Blackman, Benjamin K (Journal article; Peer reviewed, 2019)
      Here, we report a comprehensive paleogenomic study of archaeological and ethnographic sunflower remains that provides significant new insights into the process of domestication of this important crop. DNA from both ancient ...
    • Ancient DNA suggests modern wolves trace their origin to a Late Pleistocene expansion from Beringia 

      Loog, Liisa; Thalmann, Olaf; Sinding, Mikkel Holger Strander; Schuenemann, Verena J.; Perri, Angela; Germonpré, Mietje; Bocherens, Herve; Witt, Kelsey E.; Samaniego Castruita, José Alfredo; Velasco, Marcela Sandoval; Lundstrøm, Inge K.C.; Wales, Nathan; Sonet, Gontran; Frantz, Laurent; Schroeder, Hannes; Budd, Jane; Jimenez, Elodie-Laure; Fedorov, Sergey; Gasparyan, Boris; Kandel, Andrew W.; Lázničková-Galetová, Martina; Napierala, Hannes; Uerpmann, Hans-Peter; Nikolskiy, Pavel A.; Pavlova, Elena Y.; Pitulko, Vladimir V.; Herzig, Karl-Heinz; Malhi, Ripan S.; Willerslev, Eske; Hansen, Anders J.; Dobney, Keith; Gilbert, Marcus Thomas Pius; Krause, Johannes; Larson, Greger; Eriksson, Anders; Manica, Andrea (Journal article; Peer reviewed, 2019)
      Grey wolves (Canis lupus) are one of the few large terrestrial carnivores that have maintained a wide geographical distribution across the Northern Hemisphere throughout the Pleistocene and Holocene. Recent genetic studies ...
    • Ancient genomes from Iceland reveal the making of a human population 

      Ebenesersdóttir, Sigríður Sunna; Sandoval-Velasco, Marcela; Gunnarsdóttir, Ellen D.; Jagadeesan, Anuradha; Guðmundsdóttir, Valdís B.; Thordardóttir, Elísabet L.; Einarsdóttir, Margrét S.; Moore, Kristjan H. S.; Sigurðsson, Ásgeir; Magnúsdóttir, Droplaug N.; Jónsson, Hákon; Snorradóttir, Steinunn; Hovig, Eivind; Møller, Pål; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Cavalleri, Gianpiero L.; Gilbert, Edmund; Lalueza-Fox, Carles; Walser III, Joe W.; Kristjánsdóttir, Steinunn; Gopalakrishnan, Shyam; Arnadottir, Lilja; Magnússon, Ólafur Þ.; Gilbert, Marcus Thomas Pius; Stefánsson, Kári; Helgason, Agnar (Journal article; Peer reviewed, 2018)
      Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of ...
    • Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival 

      Smith, Oliver; Dunshea, Glenn; Sinding, Mikkel-Holger; Fedorov, Sergey; Germonpre, Mietje; Bocherens, Hervé; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2019)
      While sequencing ancient DNA (aDNA) from archaeological material is now commonplace, very few attempts to sequence ancient transcriptomes have been made, even from typically stable deposition environments such as permafrost. ...
    • Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing 

      Mak, Sarah S.T.; Gopalakrishnan, Shyam; Carøe, Christian; Geng, Chunyu; Liu, Shanlin; Sinding, Mikkel Holger Strander; Kuderna, Lukas FK; Zhang, Wenwei; Fu, Shujin; Vieira, Filipe G.; Germonpre, Mietje; Bocherens, Hervé; Fedorov, Sergey; Petersen, Bent; Sicheritz-Pontén, Thomas; Marques-Bonet, Tomas; Zhang, Guojie; Jiang, Hui; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2017)
      Ancient DNA research has been revolutionized following development of next-generation sequencing platforms. Although a number of such platforms have been applied to ancient DNA samples, the Illumina series are the dominant ...
    • Demographic reconstruction from ancient DNA supports rapid extinction of the Great Auk 

      Thomas, Jessica E; Carvalho, Gary R.; James, Haile; Rawlence, Nicolas J.; Martin, Michael David; Ho, Simon Y.W.; Sigfússon, Arnór; Jósefsson, Vigfús A.; Frederiksen, Morten; Linnebjerg, Jannie F.; Castruita, Jose A. Samaniego; Niemann, Jonas; Sinding, Mikkel-Holger S.; Sandoval-Velasco, Marcela; Soares, André E.R.; Lacy, Robert; Barilaro, Christina; Best, Julia; Brandis, Dirk; Cavallo, Chiara; Elorza, Mikelo; Garrett, Kimball L; Groot, Maaike; Johansson, Friederike; Lifjeld, Jan Terje; Nilson, Göran; Serjeanston, Dale; Sweet, Paul; Fuller, Errol; Hufthammer, Anne Karin; Meldgaard, Morten; Fjeldså, Jon; Shapiro, Beth; Hofreiter, Michael; Gilbert, Marcus Thomas Pius; Knapp, Michael (Journal article; Peer reviewed, 2019)
      The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by ...
    • Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria 

      Kieler, Ida Nordang; Osto, Melania; Hugentobler, Leoni; Puetz, Lara; Gilbert, Marcus Thomas Pius; Hansen, Torben; Pedersen, Oluf; Reusch, Claudia E.; Zini, Eric; Lutz, Thomas A.; Bjørnvad, Charlotte Reinhard (Peer reviewed; Journal article, 2019)
      Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to ...
    • Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny 

      Cappellini, Enrico; Welker, Frido; Pandolfi, Luca; Ramos-Madrigal, Jazmín; Samodova, Diana; Rüther, Patrick L.; Fotakis, Anna K.; Lyon, David; Moreno-Mayar, J. Víctor; Bukhsianidze, Maia; Jersie-Christensen, Rosa Rakownikow; Mackie, Meaghan; Ginolhac, Aurélien; Ferring, Reid; Tappen, Martha; Palkopoulou, Eleftheria; Dickinson, Marc R.; Stafford, Jr., Thomas W.; Chan, Yvonne L.; Götherström, Anders; Nathan, Senthilvel K.S.S.; Heintzman, Peter D.; Kapp, Joshua D.; Kirillova, Irina V.; Moodley, Yoshan; Agusti, Jordi; Kahlke, Ralf-Dietrich; Kiladze, Gocha; Martínez-Navarro, Bienvenido; Liu, Shanlin; Sandoval Velasco, Marcela; Sinding, Mikkel-Holger S.; Kelstrup, Christian D.; Allentoft, Morten E.; Orlando, Ludovic; Penkman, Kirsty; Shapiro, Beth; Rook, Lorenzo; Dalén, Love; Gilbert, Marcus Thomas Pius; Olsen, Jesper V.; Lordkipanidze, David; Willerslev, Eske (Journal article; Peer reviewed, 2019)
      The sequencing of ancient DNA has enabled the reconstruction of speciation, migration and admixture events for extinct taxa1. However, the irreversible post-mortem degradation2 of ancient DNA has so far limited its ...
    • Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features 

      Seki, Ryohei; Li, Caí; Fang, Qi; Hayashi, Shinichi; Egawa, Shiro; Hu, Jiang; Xu, Luohao; Pan, Hailin; Kondo, Mao; Sato, Tomohiko; Matsubara, Haruka; Kamiyama, Namiko; Kitajima, Keiichi; Saito, Daisuke; Liu, Yang; Gilbert, Marcus Thomas Pius; Zhou, Qi; Xu, Xing; Shiroishi, Toshihiko; Irie, Naoki; Tamura, Koji; Zhang, Guojie (Journal article; Peer reviewed, 2017)
      Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous ...
    • Genetic affinities of an eradicated european plasmodium falciparum strain 

      De-Dios, Toni; van Dorp, Lucy; Gelabert, Pere; Carøe, Christian; Sandoval-Velasco, Marcela; Fregel, Rosa; Escosa, Raül; Aranda, Carles; Huijben, Silvie; Balloux, Francois; Gilbert, Marcus Thomas Pius; Lalueza-Fox, Carles (Journal article; Peer reviewed, 2019)
      Malaria was present in most of Europe until the second half of the 20th century, when it was eradicated through a combination of increased surveillance and mosquito control strategies, together with cross-border and political ...
    • High-coverage genomes to elucidate the evolution of penguins 

      Pan, Hailin; Cole, Theresa L.; Bi, Xupeng; Fang, Miaoquan; Zhou, Chengran; Yang, Zhengtao; Ksepka, Daniel T.; Hart, Tom; Bouzat, Juan L.; Argilla, Lisa S.; Bertelsen, Mads F.; Boersma, P. Dee; Bost, Charles-André; Cherel, Yves; Dann, Peter; Fiddaman, Steven R.; Howard, Pauline; Labuschagne, Kim; Mattern, Thomas; Miller, Gary; Parker, Patricia; Phillips, Richard A.; Quillfeldt, Petra; Ryan, Peter G.; Taylor, Helen; Thompson, David R.; Young, Melanie J.; Ellegaard, Martin; Gilbert, Marcus Thomas Pius; Sinding, Mikkel Holger Strander; Pacheco, George; Shepherd, Lara D.; Tennyson, Alan J.D.; Grosser, Stefanie; Kay, Emily; Nupen, Lisa J.; Ellenberg, Ursula; Houston, David M.; Reeve, Andrew Hart; Johnson, Kathryn; Masello, Juan F.; Stracke, Thomas; McKinlay, Bruce; Borboroglu, Pablo García; Zhang, De-Xing; Zhang, Guojie (Peer reviewed; Journal article, 2019)
      Background Penguins (Sphenisciformes) are a remarkable order of flightless wing-propelled diving seabirds distributed widely across the southern hemisphere. They share a volant common ancestor with Procellariiformes ...
    • Identification of transcription factor genes involved in anthocyanin biosynthesis in carrot (Daucus carota L.) using RNA-Seq 

      Kodama, Miyako; Brinch-Pedersen, Henrik; Sharma, Shrikant; Holme, Inger B.; Joernsgaard, Bjarne; Dzhanfezova, Tsaneta; Amby, Daniel Buchvaldt; Vieira, Filipe G.; Liu, Shanlin; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2018)
      Background Anthocyanins are water-soluble colored flavonoids present in multiple organs of various plant species including flowers, fruits, leaves, stems and roots. DNA-binding R2R3-MYB transcription factors, basic ...
    • Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia) 

      Holt, Carson; Campbell, Michael; Keays, David Anthony; Edelman, Nathaniel; Kapusta, Aurélie; Maclary, Emily; Domyan, Eric T.; Suh, Alexander; Warren, Wesley C.; Yandell, Mark; Gilbert, Marcus Thomas Pius; Shapiro, Michael D. (Journal article; Peer reviewed, 2018)
      The domestic rock pigeon (Columba livia) is among the most widely distributed and phenotypically diverse avian species. C. livia is broadly studied in ecology, genetics, physiology, behavior, and evolutionary biology, and ...
    • Mind the gut: genomic insights to population divergence and gut microbial composition of two marine keystone species 

      Fietz, Katharina; Hintze, Christian O.R.; Skovrind, Mikkel; Nielsen, Tue Kjærgaard; Limborg, Morten; Krag, Marcus A.; Palsbøll, Per J.; Hansen, Lars Hestbjerg; Møller, Peter Rask; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2018)
      Background Deciphering the mechanisms governing population genetic divergence and local adaptation across heterogeneous environments is a central theme in marine ecology and conservation. While population divergence and ...
    • Molecular clocks indicate turnover and diversification of modern coleoid cephalopods during the Mesozoic marine revolution 

      Tanner, Alastair R; Fuchs, Dirk; Winkelmann, Inger E; Gilbert, Marcus Thomas Pius; Pankey, M Sabrina; Ribeiro, Angela; Kocot, Kevin M.; Halanych, Kenneth M; Oakley, Todd H; Da Fonseca, Rute R.; Pisani, Davide; Vinther, Jakob (Journal article; Peer reviewed, 2017)
      Coleoid cephalopod molluscs comprise squid, cuttlefish and octopuses, and represent nearly the entire diversity of modern cephalopods. Sophisticated adaptations such as the use of colour for camouflage and communication, ...
    • Natural selection shaped the rise and fall of passenger pigeon genomic diversity 

      Murray, Gemma G.R.; Soares, André E.R.; Novak, Ben J.; Schaefer, Nathan K.; Cahill, James A.; Baker, Allan J.; Demboski, John R.; Doll, Andrew; Da Fonseca, Rute R.; Fulton, Tara L.; Gilbert, Marcus Thomas Pius; Heintzman, Peter D.; Letts, Brandon; McIntosh, George; O'Connell, Brendan L.; Peck, Mark; Pipes, Marie-Lorraine; Rice, Edward S.; Santos, Kathryn M.; Sohrweide, A. Gregory; Vohr, Samuel H.; Corbett-Detig, Russell B.; Green, Richard E.; Shapiro, Beth (Journal article; Peer reviewed, 2017)
      The extinct passenger pigeon was once the most abundant bird in North America, and possibly the world. Although theory predicts that large populations will be more genetically diverse, passenger pigeon genetic diversity ...
    • Population genomics of grey wolves and wolf-like canids in North America 

      Sinding, Mikkel Holger Strander; Gopalakrishnan, Shyam; Vieira, Filipe G.; Samaniego, Jose A; Raundrup, Katrine; Heide Jørgensen, Mads Peter; Meldgaard, Morten; Petersen, Bent; Sicheritz-Ponten, Thomas; Mikkelsen, Johan Brus; Marquard-Petersen, Ulf; Dietz, Rune; Sonne, Christian; Dalén, Love; Bachmann, Lutz; Wiig, Øystein; Hansen, Anders J.; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2018)
      North America is currently home to a number of grey wolf (Canis lupus) and wolf-like canid populations, including the coyote (Canis latrans) and the taxonomically controversial red, Eastern timber and Great Lakes wolves. ...