• Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...
    • Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use 

      Liu, Ming; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M.; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; Mitchell, Amy; Skogholt, Anne Heidi; Sivertsen, Børge; Stordal, Eystein; Morken, Gunnar; Kallestad, Håvard; Heuch, Ingrid; Zwart, John-Anker; Fjukstad, Katrine Kveli; Pedersen, Linda Margareth; Johnsen, Marianne Bakke; Skrove, Marit Synnøve; Indredavik, Marit Sæbø; Drange, Ole Kristian; Bjerkeset, Ottar; Børte, Sigrid; Stensland, Synne; Choquet, Hélène; Docherty, Anna R.; Faul, Jessica D.; Foerster, Johanna R.; Fritsche, Lars; Gabrielsen, Maiken Elvestad; Gordon, Scott D.; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R.; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrú, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W.; Smith, Jennifer A.; Taylor, Amy E.; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A.; Zajac, Gregory J.M.; Zhao, Wei; Zhou, Wei; Björnsdóttir, Gyda Thora; Boardman, Jason D.; Boehnke, Michael; Boomsma, Dorret I.; Chen, Chu; Davies, Gareth E.; Eaton, Charles B.; Winsvold, Bendik K S; Hveem, Kristian; Vrieze, Scott (Journal article; Peer reviewed, 2019)
      Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery ...
    • Biological and Clinical Insights From Genetics of Insomnia Symptoms 

      Lane, Jacqueline M.; Jones, Samuel E.; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Brumpton, Ben Michael; Zwart, John-Anker; Nielsen, Jonas Bille; Winswold, Bendik; Willer, Cristen J; Janszky, Imre; Johnsen, Marianne Bakke; Wood, Andrew R.; Strand, Linn B.; Bowden, Jack; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Beaumont, Robin N.; Bechtold, David A.; Cade, Brian E.; Kathiresan, Sekar; Little, Max A.; Loudon, Andrew S.; Purcell, Shaun; Richmond, Rebecca C.; Schormair, Barbara; Tyrrell, Jessica; Winkelmann, Juliane; Zhao, Cheng; Redline, Susan; Spiegelhalder, Kai; Kyle, Simon D.; Frayling, Timothy M.; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we ...
    • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Peer reviewed; Journal article, 2020)
      Background: The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphism (SNP) score on the risk ...
    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...
    • Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study 

      Johnsen, Marianne Bakke; Magnusson, Karin; Børte, Sigrid; Gabrielsen, Maiken Elvestad; Winsvold, Bendik K S; Skogholt, Anne Heidi; Thomas, Laurent; Storheim, Kjersti; Hveem, Kristian; Zwart, John-Anker (Peer reviewed; Journal article, 2020)
      Objective To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design We included 17,153 men and 18,682 ...
    • Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools 

      Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Peer reviewed; Journal article, 2022)
      Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are ...
    • The effect of smoking intensity on all-cause and cause-specific mortality-a Mendelian randomization analysis. 

      Vie, Gunnhild Åberge; Wootton, Robyn E; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Taylor, AE; Gabrielsen, Maiken Elvestad; Davey, George Smith; Romundstad, Pål Richard; Munafo, Marcus R (Peer reviewed; Journal article, 2019)
      Background Smoking is an important cause of mortality and recent studies have suggested that even low-intensity smoking might be associated with increased mortality. Still, smoking is associated with lower socio-economic ...
    • Exome chip analyses in adult attention deficit hyperactivity disorder 

      Zayats, Tetyana; Jacobsen, Kaya Kvarme; Kleppe, Rune; Jacob, CP; Kittel-Schneider, Sarah; Ribases, Marta; Ramos-Quiroga, JA; Richarte, Vanesa; Casas, M; Mota, NR; Grevet, EH; Klein, M; Corominas, J; Bralten, Janita; Galesloot, T; Vasquez, AA; Herms, S; Forstner, AJ; Larsson, H; Breen, G; Asherson, P; Gross-Lesch, Silke; Lesch, KP; Cichon, Sven; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Bau, CH; Buitelaar, Jan; Kiemeney, L; Faraone, Stephen V.; Cormand, B; Franke, Barbara; Reif, Andreas; Haavik, Jan; Johansson, Stefan (Journal article; Peer reviewed, 2016)
      Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, is largely unknown. ...
    • Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism 

      Paulsen, Benedikte; Skille, Hanne; Smith, Erin N.; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brækkan, Sigrid Kufaas; Rosendaal, Frits Richard; Frazer, Kelly A.; Gran, Olga Vikhammer; Hansen, John-Bjarne (Peer reviewed; Journal article, 2019)
      Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant ...
    • Genetic Risk Factors for Lung Cancer: Relationship to Smoking Habits and Nicotine Addiction: The Nord-Trøndelag (HUNT) and Tromsø Health Studies 

      Gabrielsen, Maiken Elvestad (Doktoravhandlinger ved NTNU, 1503-8181; 2013:87, Doctoral thesis, 2013)
    • Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article, 2019)
    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Peer reviewed; Journal article, 2021)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...
    • Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease 

      Zheng, Thenghao; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Thomas, Laurent; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2021)
      Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ...
    • A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease 

      Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik K S; Drange, Ole Kristian; Martinsen, Amy E.; Skogholt, Anne Heidi; Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; Nielsen, Jonas Bille; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Meisingset, Tore Wergeland; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Sealock, Julia; Davis, Lea K.; Pedersen, Nancy L.; Reynolds, Chandra A.; Karlsson, Ida K.; Magnusson, Sigurdur; Stefansson, Hreinn; Thordardottir, Steinunn; Jónsson, Pálmi V.; Snædal, Jon; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Waern, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John Anker Henrik; Athanasiu, Lavinia; Selnes, Per; Saltvedt, Ingvild; Sando, Sigrid Botne; Ulstein, Ingun; Djurovic, Srdjan; Fladby, Tormod; Aarsland, Dag; Selbæk, Geir; Ripke, Stephan; Stefánsson, Kári; Andreassen, Ole; Posthuma, Danielle (Journal article; Peer reviewed, 2021)
      Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. ...
    • GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 

      Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne R.; Karjalainen, Juha; Kurki, Mitja I.; Oneka, Morgan; Taylor, Peter; Fritsche, Lars; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Bordal, Eirin Haug; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana; Mayordomo, Jose; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark J.; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ...
    • Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis 

      Bjørngaard, Johan Håkon; Nordestgaard, AT; Taylor, Amy E; Treur, Jorien L; Gabrielsen, Maiken Elvestad; Munafo, Marcus R; Nordestgaard, BG; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Davey Smith, George (Journal article; Peer reviewed, 2017)
      Background There is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases metabolism of caffeine, so this may represent a causal effect of smoking on caffeine ...
    • Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium 

      Morris, Richard W.; Taylor, Amy E.; Fluharty, Meg E.; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N.; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L.; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S. Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M.; Kennedy, Martin A.; Nohr, Ellen A.; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G.; Whincup, Peter H.; Vink, Jacqueline M.; Boomsma, Dorret I.; Smith, George Davey; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J. Wouter; Power, Chris; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H.; Hayward, Caroline; Romundstad, Pål Richard; Sørensen, Thorkild I.A.; Munafo, Marcus R.; Sattar, Naveed (Journal article; Peer reviewed, 2015)
      Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: ...
    • Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Evensen, Line Holtet; Morelli, Vania Maris; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Njølstad, Inger; Mathiesen, Ellisiv B.; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Peer reviewed, 2019)
      Background Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives To investigate the effect of prothrombotic genotypes on the association between FHMI ...
    • Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls 

      Timofeeva, M N; Hung, R J; Rafnar, T; Christiani, D C; Field, J K; Bickeboller, H; Risch, A; McKay, J D; Wang, Y; Dai, J; Gaborieau, V; McLaughlin, J; Brenner, D; Narod, S A; Caporaso, NE.; Albanes, D; Thun, M; Eisen, T; Wichmann, H E; Rosenberger, A; Han, Y; Chen, W; Zhu, D; Spitz, M; Wu, X; Pande, M; Zhao, Y; Zaridze, D; Szeszenia-Dabrowska, N; Lissowska, J; Rudnai, P; Fabianova, E; Mates, D; Bencko, V; Foretova, L; Janout, V; Krokan, Hans Einar; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars Johan; Njølstad, Inger; Chen, C; Goodman, G; Lathrop, M; Benhamou, S; Vooder, T; Valk, K; Nelis, M; Metspalu, Andres; Raji, O; Chen, Y; Gosney, J; Liloglou, T; Muley, T; Dienemann, H; Thorleifsson, G; Shen, H.; Stefansson, Kari; Brennan, Paul; Amos, C I; Houlston, Richard; Landi, M T (Journal article; Peer reviewed, 2012)