Blar i NTNU Open på forfatter "Fayers, Peter"
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A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
Solheim, Tora Skeidsvoll; Laird, Barry J; Balstad, Trude Rakel; Stene, Guro Birgitte; Bye, Asta; Johns, Neil; Pettersen, Caroline Hild Hakvåg; Fallon, Marie; Fayers, Peter; Fearon, Kenneth; Kaasa, Stein (Journal article; Peer reviewed, 2017)Background: Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. ... -
Detailed statistical analysis plan for the Danish Palliative care trial (DanPaCT)
Johnsen, Anna T; Petersen, Morten A; Gluud, Christian; Lindschou, Jane; Fayers, Peter; Sjøgren, Per; Pedersen, Lise; Neergaard, Mette A; Vejlgaard, Tove Bahn; Damkier, Anette; Nielsen, Jan B; Strömgren, Annette S; Higginson, Irene J; Groenvold, Mogens (Journal article; Peer reviewed, 2014)Background Advanced cancer patients experience considerable symptoms, problems, and needs. Early referral of these patients to specialized palliative care (SPC) could offer improvements. The Danish Palliative Care Trial ... -
Development of the EORTC QLQ-CAX24, A Questionnaire for Cancer Patients With Cachexia
Wheelwright, Sally J.; Hopkinson, Jane B.; Darlington, Anne-Sophie; Fitzsimmons, Deborah F.; Fayers, Peter; Balstad, Trude Rakel; Bredart, Anne; Hammerlid, Eva; Kaasa, Stein; Nicolatou-Galitis, Ourania; Pinto, Monica; Schmidt, Heike; Solheim, Tora Skeidsvoll; Strasser, Florian; Tomaszewska, IM; Johnson, Colin D. (Journal article; Peer reviewed, 2017)Context Cachexia is commonly found in cancer patients and has profound consequences; yet there is only one questionnaire that examines the patient's perspective. Objective To report a rigorously developed module for ... -
Differential item functioning (DIF) analyses of health-related quality of life instruments using logistic regression
Scott, Neil W; Fayers, Peter; Aaronson, Neil K; Bottomley, Andrew; de Graeff, Alexander; Groenvold, Mogens; Gundy, Chad; Koller, Michael; Petersen, Morten A; Sprangers, Mirjam AG (Journal article; Peer reviewed, 2010)Background: Differential item functioning (DIF) methods can be used to determine whether different subgroups respond differently to particular items within a health-related quality of life (HRQoL) subscale, after allowing ... -
Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews
Higginson, Irene J.; Evans, Catherine J.; Grande, Gunn; Preston, Nancy; Morgan, Myfanwy; McCrone, Paul; Lewis, Penney; Fayers, Peter; Harding, Richard; Hotopf, Matthew; Murray, Scott A.; Benalia, Hamid; Gysels, Marjolein; Farquhar, Morag; Todd, Chris (Journal article; Peer reviewed, 2013)Background Despite being a core business of medicine, end of life care (EoLC) is neglected. It is hampered by research that is difficult to conduct with no common standards. We aimed to develop evidence-based guidance on ... -
Genetic and Non-genetic Factors Associated WithConstipation in Cancer Patients Receiving Opioids
Laugsand, Eivor Alette; Skorpen, Frank; Kaasa, Stein; Sabatowski, Rainer; Strasser, Florian; Fayers, Peter; Klepstad, Pål (Journal article; Peer reviewed, 2015)Objectives: To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors. Methods: Cancer patients receiving ... -
Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches
Fielding, S; Fayers, Peter; Ramsay, CR (Journal article; Peer reviewed, 2009)Background: Missing data is classified as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR). Knowing the mechanism is useful in identifying the most appropriate analysis. The ... -
Is progression-free survival associated with a better health-related quality of life in patients with lung cancer? Evidence from two randomised trials with afatinib
Griebsch, Ingolf; Palmer, Michael; Fayers, Peter; Ellis, Stuart (Journal article; Peer reviewed, 2014)Objective: Progression-free survival (PFS) is frequently used as an efficacy end point in oncology clinical trials. However, there is limited evidence to support a positive association between improvement in PFS and ... -
Is there a genetic cause of appetite loss? - An explorative study in 1853 cancer patients
Solheim, Tora Skeidsvoll; Fayers, Peter; Fladvad, Torill; Tan, Ben; Skorpen, Frank; Fearon, Kenneth C.; Baracos, Vickie; Klepstad, Pål; Strasser, Florian; Kaasa, Stein (Journal article; Peer reviewed, 2012)Background Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi‐factorial syndrome defined by a ... -
Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review
Hislop, Jenni; Adewuyi, Temitope E.; Vale, Luke D.; Harrild, Kirsten; Fraser, Cynthia; Gurung, Tara; Altman, Douglas G.; Briggs, Andrew H.; Fayers, Peter; Ramsay, Craig R.; Norrie, John D.; Harvey, Ian M.; Buckley, Brian; Cook, Jonathan A. (Journal article; Peer reviewed, 2014)Background Randomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified ... -
Minimal important differences and response shift in health-related quality of life; a longitudinal study in patients with multiple myeloma
Kvam, Ann Kristin; Wisløff, Finn Georg B; Fayers, Peter (Journal article; Peer reviewed, 2010)Background: We previously reported that changes of 6-17 percent in the EORTC QLQ-C30 scores are regarded important by patients with multiple myeloma and thus may be considered as Minimal Important Differences (MIDs). ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
Jakobsen, Gunnhild; Engstrøm, Morten; Hjermstad, Marianne Jensen; Rosland, Jan Henrik; Aass, Nina Kathrine; Albert, Eva; Kaasa, Stein; Fayers, Peter; Klepstad, Pål; Paulsen, Ørnulf (Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Simple imputation methods were inadequate for missing not at random (MNAR) quality of life data
Fielding, S; Fayers, Peter; McDonald, A; McPherson, G; Campbell, MK (Journal article; Peer reviewed, 2008)Objective: QoL data were routinely collected in a randomised controlled trial (RCT), which employed a reminder system, retrieving about 50% of data originally missing. The objective was to use this unique feature to ... -
Sleep quality in hospitalized patients with advanced cancer: an observational study using self-reports of sleep and actigraphy
Jakobsen, Gunnhild; Engstrøm, Morten; Thronæs, Morten; Løhre, Erik Torbjørn; Kaasa, Stein; Fayers, Peter; Hjermstad, Marianne Jensen; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose Although patients with advanced cancer report poor sleep quality, few studies have assessed sleep quality with a combination of subjective and objective measures. We aimed to examine sleep quality in hospitalized ... -
Sleep quality with WHO Step III opioid use for cancer pain
Jakobsen, Gunnhild; Engstrøm, Morten; Fayers, Peter; Hjermstad, Marianne Jensen; Kaasa, Stein; Kloke, Marianne; Sabatowski, Rainer; Klepstad, Pål (Journal article; Peer reviewed, 2018)Objective Sleep is often disturbed in patients with advanced cancer. There is limited knowledge about sleep in patients with cancer treated with strong opioids. This study examines sleep quality in patients with advanced ... -
Specifying the target difference in the primary outcome for a randomised controlled trial: Guidance for researchers
Cook, Jonathan A.; Hislop, Jenni; Altman, Douglas G.; Fayers, Peter; Briggs, Andrew H.; Ramsay, Craig R.; Norrie, John D.; Harvey, Ian M.; Buckley, Brian; Fergusson, D; Ford, Ian; Vale, Luke D. (Journal article; Peer reviewed, 2015)Background Central to the design of a randomised controlled trial is the calculation of the number of participants needed. This is typically achieved by specifying a target difference and calculating the corresponding ... -
The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis
Vagnildhaug, Ola Magne; Blum, David; Wilcock, Andrew; Fayers, Peter; Strasser, Florian; Baracos, Vickie E.; Hjermstad, Marianne Jensen; Kaasa, Stein; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2017)Background A body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic ... -
The Edmonton Symptom Assessment System: Poor performance as a screener for major depression in patients with incurable cancer
Brenne, Elisabeth; Loge, Jon Håvard; Lie, Hanne Cathrine; Hjermstad, Marianne Jensen; Fayers, Peter; Kaasa, Stein (Journal article; Peer reviewed, 2016)Background: Depressive symptoms are prevalent in patients with advanced cancer, sometimes of a severity that fulfil the criteria for a major depressive episode. Aim: The aim of this study was to investigate how the item ... -
The EORTC CAT Core - The computer adaptive version of the EORTC QLQ-C30 questionnaire
Petersen, Morten Aa.; Aaronson, Neil K.; Arraras, Juan I; Chie, Wei-Chu; Conroy, Thierry; Costantini, Anna; Dirven, Linda; Fayers, Peter; Gamper, Eva-Maria; Giesinger, Johannes M; Habets, Esther J.J.; Hammerlid, Eva; Helbostad, Jorunn L.; Hjermstad, Marianne Jensen; Holzner, Bernhard; Johnson, Colin; Kemmler, Georg; King, Madeleine T.; Kaasa, Stein; Loge, Jon Håvard; Reijneveld, Jaap C.; Singer, Susanne; Taphoorn, Martin J. B.; Thamsborg, Lise H.; Tomaszewski, Krzysztof A.; Velikova, Galina; Verdonck-de Leeuw, Irma M.; Young, Teresa; Groenvold, Mogens (Journal article; Peer reviewed, 2018)Background To optimise measurement precision, relevance to patients and flexibility, patient-reported outcome measures (PROMs) should ideally be adapted to the individual patient/study while retaining direct comparability ... -
The relationship between pro-inflammatory cytokines and pain, appetite and fatigue in patients with advanced cancer
Paulsen, Ørnulf; Laird, Barry J; Aass, Nina Kathrine; Lea, Tor Erling; Fayers, Peter; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2017)Background Systemic inflammation is associated with reduced quality of life and increased symptoms in patients with advanced cancer. The aims of this study were to examine the relationships between inflammatory biomarkers ...