• Basal markers and prognosis in luminal breast cancer 

      Engstrøm, Monica J; Valla, Marit; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Purpose Basal marker expression in triple-negative breast cancers identifies basal-like tumours, and thus separates the TN group into two prognostic groups. However, the expression and prognostic significance of basal ...
    • Characterization of FGD5 expression in primary breast cancers and lymph node metastases 

      Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ...
    • FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis 

      Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Purpose Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ...
    • Invasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypes 

      Engstrøm, Monica J; Opdahl, Signe; Vatten, Lars Johan; Haugen, Olav Anton; Bofin, Anna M. (Peer reviewed; Journal article, 2015)
      Aims The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of ...
    • Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences 

      Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Journal article; Peer reviewed, 2016)
      Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 ...
    • Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients 

      Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. (Peer reviewed; Journal article, 2013)
      Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ...
    • MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes 

      Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Peer reviewed; Journal article, 2020)
      Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ...
    • The prognostic value of androgen receptors in breast cancer subtypes 

      Kraby, Maria Ryssdal; Valla, Marit; Opdahl, Signe; Haugen, Olav Anton; Sawicka, Joanna Ewa; Engstrøm, Monica J; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Purpose Androgen receptor (AR) expression is frequent in breast cancer and has been associated with good prognosis in several studies. The present study investigates AR-expression in relation to molecular subtypes, ...
    • TOP2A gene copy number change in breast cancer 

      Engstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2014)
      Aims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone ...