Blar i NTNU Open på forfatter "Engedal, Knut"
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A 52 month follow-up of functional decline in nursing home residents - Degree of dementia contributes
Helvik, Anne-Sofie; Engedal, Knut; Saltyte Benth, Jurate; Selbæk, Geir (Journal article; Peer reviewed, 2014)Background: Few have studied how personal activities of daily living (P-ADL) develop over time in nursing home residents with dementia. Thus, the aim was to study variables associated with the development of P-ADL functioning ... -
Alcohol and prescribed psychotropic drug use among patients admitted to a department of old age psychiatry in Norway
Johannessen, Aud; Engedal, Knut; Larsen, Marianne; Lillehovde, Elin Johnsen; Stelander, Line; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2017)Background: Although alcohol and prescribed psychotropic drug use has increased among older people, the usefulness of information provided about these substances in patients’ referrals to departments of old-age psychiatry ... -
Alcohol consumption and use of drugs with addiction potential in older adults – a population-based study
Tevik, Kjerstin Elisabeth (Doctoral theses at NTNU;2019:256, Doctoral thesis, 2019) -
Alzheimer's Disease - The Impact of Vascular Comorbidity on Disease Progression and Clinical Profile
Eldholm, Rannveig Sakshaug (Doctoral theses at NTNU;2019:77, Doctoral thesis, 2019) -
Applicability of the locus of control of behaviour scale for people with dementia
Halse, Ingeborg; Björklöf, Guro Hanevold; Engedal, Knut; Rokstad, Anne Marie Mork; Persson, Karin Ester Torun; Eldholm, Rannveig Sakshaug; Selbæk, Geir; Barca, Maria Lage (Journal article; Peer reviewed, 2019)Objective: To investigate the applicability of the Locus of Control of Behaviour scale (LoCB) for people with dementia. Method: A sample of 534 participants with dementia (78.4 mean age, 58% female) were included. Assessment ... -
Assessment of alcohol and psychotropic drug use among old-age psychiatric patients in Norway: Experiences of health professionals
Johannessen, Aud; Engedal, Knut; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2017)Background: Increased awareness among health professionals regarding older people’s alcohol and prescribed psychotropic drug use may be beneficial for reducing their unhealthy consumption among elderly. Aim: This study ... -
Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics
Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Barca, Maria Lage; Knapskog, Anne Brita; Cavallin, Lena; Engedal, Knut; Skovlund, Eva; Saltvedt, Ingvild; Selbaek, Geir (Journal article; Peer reviewed, 2018)Background: Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this ... -
Being stuck in a vice: The process of coping with severe depression in late life
Björklöf, Guro Hanevold; Kirkevold, Marit; Engedal, Knut; Selbæk, Geir; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2015)Articles describing older persons’ experiences of coping with severe depression are, to our knowledge, lacking. This article is methodologically grounded in phenomenological hermeneutics, inspired by Paul Ricoeur, and ... -
Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification
Knapskog, Anne Brita; Henjum, Kristi; Idland, Ane-Victoria; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Saltvedt, Ingvild; Watne, Leiv; Engedal, Knut; Nilsson, Lars N.G. (Peer reviewed; Journal article, 2020)Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). Previous studies ... -
Cortisol levels among older people with and without depression and dementia
Barca, Maria Lage; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Björklöf, Guro Hanevold; Borza, Tom; Telenius, Elisabeth Wiken; Knapskog, Anne-Brita; Brækhus, Anne; Saltvedt, Ingvild; Selbæk, Geir; Engedal, Knut (Journal article; Peer reviewed, 2018)Cortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 ... -
Cost analysis of day care centres in Norway
Vossius, Corinna Elisabeth; Selbæk, Geir; Saltyte Benth, Jurate; Wimo, A.; Engedal, Knut; Kirkevold, Øyvind; Rokstad, Anne Marie Mork (Journal article; Peer reviewed, 2019)Background: Day care services aim to offer meaningful activities and a safe environment for the attendees and a respite for family caregivers while being cost effective. This study compares the use of formal and informal ... -
Experiences and needs of spouses of persons with young-onset frontotemporal dementia during the progression of the disease
Johannessen, Aud; Helvik, Anne-Sofie; Engedal, Knut; Thorsen, Kirsten (Journal article; Peer reviewed, 2017)Background Two of the most common types of young-onset dementia (<65 years old) are Alzheimer's disease and frontotemporal lobe dementia (FTLD). A limited amount of research that focuses on the needs of spouses of persons ... -
Exploration of 27 plasma immune markers: A cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
Gaarden, Torfinn Lødøen; Engedal, Knut; Saltyte Benth, Jurate; Larsen, Marianne; Lorentzen, Bernhard; Mollnes, Tom Eirik; Bjølseth, Tor Magne; Castellheim, Albert (Journal article; Peer reviewed, 2018)Background The prevalence of major depression (MD) according to population studies is the same for old (65 years and older) and younger adults. In contrast, an elevated proportion of old MD patients are hospitalized ... -
Exploring the trajectories of quality of life and its covariates in nursing home residents: A longitudinal study
Røen, Irene Mari; Saltyte Benth, Jurate; Kirkevold, Øyvind; Testad, Ingelin; Selbæk, Geir; Engedal, Knut; Bergh, Sverre (Journal article; Peer reviewed, 2019)Background: There is no cure for dementia and appropriate care should be offered to improve or maintain quality of life for those living with dementia. Objectives: To identify groups of residents following similar trajectories ... -
Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men – the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study
Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)Background Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic ... -
Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients
Knapskog, Anne Brita; Eldholm, Rannveig Sakshaug; Brækhus, Anne; Engedal, Knut; Saltvedt, Ingvild (Journal article; Peer reviewed, 2017)Background The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer’s disease. The diagnostic power of these ... -
Health-related quality of life in older depressed psychogeriatric patients: one year follow-up
Helvik, Anne-Sofie; Corazzini, Kirsten; Selbæk, Geir; Björklöf, Guro Hanevold; Laks, Jerson; Saltyte Benth, Jurate; Østbye, Truls; Engedal, Knut (Peer reviewed; Journal article, 2016)Background Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change ... -
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Edwin, Trine Holt; Henjum, Kristi; Nilsson, Lars N. G.; Watne, Leiv; Persson, Karin Ester Torun; Eldholm, Rannveig Sakshaug; Saltvedt, Ingvild; Halaas, Nathalie Bodd; Selbæk, Geir; Engedal, Knut; Strand, Bjørn Heine; Knapskog, Anne Brita (Peer reviewed; Journal article, 2020)Introduction: The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity. We explored if cerebrospinal fluid (CSF) soluble TREM2 ... -
Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ... -
Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential – The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study
Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)Background The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential ...