Browsing NTNU Open by Author "Einen, Caroline"
Now showing items 1-12 of 12
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Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti (Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Characterization of Multicellular Spheroids as a Method for Drug Delivery Studies
Brunstøl, Karina (Master thesis, 2023)Multicellulære sfæroider (MCSer) er 3D-tumormodeller som ved å bedre etterligne tumor-mikromiljøet (TME) kan forbedre in vitro-kreftforskning med mål om å redusere behovet for dyreforsøk. Formål: Å karakterisere MCSer fra ... -
Characterization of the mechanical properties of pancreatic, breast, and colon tumor models
Devold, Ella Johanne (Master thesis, 2023)Den tette og stive ekstracellulære matriksen i kreftsvulster danner en fysisk barriere som hindrer tilførsel av medisiner og dermed hemmer kreftbehandling. I dette prosjektet har stivheten til tre tumormodeller fra mus ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Composite PACA Nanoparticle-Alginate Microspheres for Sustained Drug Delivery - Characterization, Optimization, In Vitro Drug Release and Cytotoxicity Studies
Einen, Caroline; Benjakul, Sopisa (Master thesis, 2018) -
Effect of Ultrasound and Microbubble Treatment on Tumor Vasculature and Liposomal Uptake in Murine Cancer Models
Kastellet, Andrea Berge (Master thesis, 2023)Hensikt: Målet med denne oppgaven var å undersøke om ultralyd- og mikroboblebehandling (USMB) kan forbedre levering av nanomedisin i murine tumormodeller. Nærmere bestemt ble effekten av USMB på tumorperfusjon og på opptak ... -
Effect of Ultrasound and Microbubbles on Vasculature and Extracellular Matrix Components in Murine Breast Cancer Tumors
Årseth, Charlotte (Master thesis, 2022)Suksessfull kreftbehandling har i mange år vært hindret av utilstrekkelig leveranse av medisiner. En tilnærming til dette problemet er å bruke ultralyd og mikrobobler (USMB) for å overkomme problemer relatert til vaskulatur ... -
Identifying Barriers in Extracellular Matrix for Ultrasound-Mediated Delivery of Nanoparticles in 4T1, KPC and CT26 Tumor Models
Wesche, Håkon Fossland (Master thesis, 2023)En av utfordringene ved dagens kreftbehandlinger er at kun en liten del av medisinene akkumuleres i svulsten. Man tror noe av grunnen til dette skyldes at den ekstracellulære matriksen (ECM) i svulstvevet er ekstra tettpakket. ... -
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound
Einen, Caroline; Price, Sebastian Everard Nordby; Ulvik, Kim; Gjennestad, Magnus Aashammer; Hansen, Rune; Kjelstrup, Signe; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate ... -
A new facility for viscosity and density measurements for CO2 – rich mixtures relevant for CO2 transport and storage
Khosravi, Bahareh; Austegard, Anders; Stang, Hans Georg Jacob; Einen, Caroline; Jakobsen, Jana Poplsteinova; Snustad, Ingrid; Løvseth, Sigurd Weidemann (Journal article, 2022)For safe and cost-effective design, optimization, and operation of CO2 capture, transport, and storage (CCS) processes, accurate viscosity and density data of CO2-rich mixtures are required. Currently, there are large ... -
Ultrasound enhanced diffusion in hydrogels: An experimental and non-equilibrium molecular dynamics study
Price, Sebastian Everard Nordby; Einen, Caroline; Moultos, Othonas A.; Vlugt, Thijs J. H.; Davies, Catharina de Lange; Eiser, Erika; Lervik, Anders (Journal article; Peer reviewed, 2024)Focused ultrasound has experimentally been found to enhance the diffusion of nanoparticles; our aim with this work is to study this effect closer using both experiments and non-equilibrium molecular dynamics. Measurements ... -
Uptake and Distribution of Nanoparticles in Multicellular Spheroids
Krog, Ida (Master thesis, 2024)Purpose: Cancer is a medical condition characterized by the uncontrolled growth and spread of certain cells within the body, making it the second leading cause of death worldwide. Chemotherapy is a crucial treatment for ...