Browsing NTNU Open by Author "Davies, Catharina de Lange"
Now showing items 1-20 of 85
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Acoustic and Mechanical Properties of Microbubbles Stabilized by Polymeric Nanoparticles
Finnøy, Andreas (Master thesis, 2013)This thesis examines acoustic and mechanical properties of microbubbles stabilized bypoly(butyl cyanoacrylate) nanoparticles. The microbubbles are developed with the purposeof being applied in combination with ultrasound ... -
Acoustic Cluster Therapy (ACT) and Induced Immune Response
Sripalan, Gopana (Master thesis, 2021)Abstract will be available on 2024-08-01 -
Acoustic Cluster Therapy (ACT) induced immune response in the brain and characterization of ACT cluster activation
Olsen, Emma Bøe (Master thesis, 2021)Abstract will be available on 2024-08-01 -
Acoustic Cluster Therapy in the chicken chorioallantoic membrane model
Nymark, Ellen Helgeland (Master thesis, 2018)In this thesis the chicken chorioallantoic membrane (CAM) model was used to study the enhanced delivery of intravenously injected \SI{2}{\mega\dalton} FITC-dextrans using ultrasound in combination with microbubbles. An ... -
Addressing the barriers for delivery of liposomal nanoparticles to tumors
Andreassen, Kristine (Master thesis, 2018)This study concerns the enhanced delivery of three types of fluorescently labelled liposomal nanoparticles to prostate cancer xenographs. Passive delivery of the liposomes was achieved by utilizing the enhanced permeability ... -
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti (Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Cellular Interaction with Polymeric Nanoparticles: The Effect of PEGylation and Monomer Composition
Westrøm, Sara (Master thesis, 2013)It is of importance to understand which nanoparticle properties that govern the interactions between particles and cells, in order to develop a nanocarrier with the desired functionality. In this thesis, nanoparticles made ... -
Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
Sulheim, Einar*; Baghirov, Habib*; von Haartman, Eva; Bøe, Andreas; Åslund, Andreas; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange (Journal article; Peer reviewed, 2016)Background Poly(alkyl cyanoacrylate) (PACA) nanoparticles have shown promise as drug carriers both to solid tumors and across the blood–brain barrier. Efficient drug delivery requires both high cellular uptake of the ... -
Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
Urdal, Jo Endre Brauten (Master thesis, 2020)Nanopartikler kan forbedre effekten og biodistribusjonen, og redusere toksisiteten til allerede eksisterende legemidler ved å innkapsle dem. I tillegg, nanopartikler kan legge til rett for leveringen av legemidler som er ... -
Cellular Uptake of Nanoparticles by Sonoporation
Hanstad, Sigurd (Master thesis, 2017)Encapsulation of anti-cancer drugs in nanoparticles (NPs) can solve many of the problems and side-effects related to cancer treatment today. By exposing micrometer-sized gas-filled bubbles to ultrasound, cellular uptake ... -
Characterization of Multicellular Spheroids as a Method for Drug Delivery Studies
Brunstøl, Karina (Master thesis, 2023)Multicellulære sfæroider (MCSer) er 3D-tumormodeller som ved å bedre etterligne tumor-mikromiljøet (TME) kan forbedre in vitro-kreftforskning med mål om å redusere behovet for dyreforsøk. Formål: Å karakterisere MCSer fra ... -
Characterization of the Uptake and Trafficking of AvB3-targeted and Non-targeted Nanoemulsions in Human Endothelial Cells in vitro
Helgesen, Emily (Master thesis, 2011)RGD-functionalized and non-functionalized oil-in-water nanoemulsions of approximately 100 nm containing DSPC, PEGylated DSPE, cholesterol and Gd-DTPA-DSA at a molar ratio of 1.1/0.15/1/0.75 were prepared. In vitro uptake ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Comparing the caveolae mediated endocytosis of two DNA-chitosan polyplexes
Folasire, Oladayo (Master thesis, 2011)Understanding intracellular processing of gene vectors will help to improve vector design in gene therapy. Chitosan nanoparticles have been previously identied as safe and non toxic gene vector. Linear chitosan oligomer ... -
Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage
Kumar, Rajesh; Pierce, David M.; Isaksen, vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2018)Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular ... -
Composite PACA Nanoparticle-Alginate Microspheres for Sustained Drug Delivery - Characterization, Optimization, In Vitro Drug Release and Cytotoxicity Studies
Einen, Caroline; Benjakul, Sopisa (Master thesis, 2018) -
Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer's Disease Model
Sulheim, Einar; Widerøe, Marius; Bäck, Marcus; Nilsson, K Peter R; Hammarström, Per; Nilsson, Lars; Davies, Catharina de Lange; Åslund, Karl Olof Andreas (Journal article; Peer reviewed, 2023)Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer’s disease (AD) because neuronal damage by the Aβ aggregates occurs before clinical symptoms are apparent. ... -
Cooling of Transducer array used for Ultrasound radiation Force
Risbakk, Håkon (Master thesis, 2015)This thesis proposed a way to cool an ultrasound transducer. The cooling method is to have a an area on the casing of the transducer that has a high thermal conductivity, and a high emissivity. This layer is meant to ... -
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Degradation and Stability of PBCA and POCA Nanoparticles
Bøe, Andreas Gagnat (Master thesis, 2013)Nanoparticles represent promising carriers for controlled drug delivery. In this project threedifferent intruments: Zetasizer, Nanosight and Gas Chromatography, have been used to detect and analyse degradation of monodisperse ...