Blar i NTNU Open på forfatter "Bugge, Marit"
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ... -
Characterization of in vitro polarized human neutrophils - a model for testing how cancer cells affect neutrophil polarization
Seljeseth, Emilie (Master thesis, 2021)Nøytrofile er de mest tallrike leukocyttene i den menneskelige sirkulasjonen og de første cellene som rekrutteres til infeksjons- og betennelsessteder. Disse medfødte immuncellene er hovedaktører i vertsimmuniteten og har ... -
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis
Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ... -
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ... -
Endogenous ligands secreted by multiple myeloma cell lines activate TLRs 7, 8, and 9
Vatn, Susanne (Master thesis, 2020) -
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article, 2013)We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD), in an extensive material of ulcerative colitis (UC) and Crohn`s disease (CD). The chemokine CXCL10 and its receptor ... -
Investigating iPSC derived macrophages as a model to study Mtb infection compared to alveolar macrophages, monocyte derived macrophages and THP-1 macrophages
Horn, Nils Ulrik Crawford (Master thesis, 2022)Mycobacterium tuberculosis (Mtb) er fortsatt et omfattende folkehelseproblem for en stor del av verdens utviklingsland, og forårsaker mer enn 1,5 millioner dødsfall årlig. Imidlertid forblir mange aspekter av interaksjonene ... -
Metastatic Cancerous Intestinal Epithelial Cells express Toll-like receptor 3 and release RANTES/CCL5 and IP-10/CXCL10 in response to Double-stranded RNA
Bugge, Marit (Master thesis, 2011)Toll-like receptors (TLR)s are important for mounting an inflammatory response against invading microorganisms by recognizing pathogen-associated molecular patterns (PAMP)s, which are rare or absent in vertebrates. TLRs ... -
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness
Bugge, Marit; Bergstrøm, Bjarte; Oda Kamilla, Eide; Helene, Solli; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J. (Journal article; Peer reviewed, 2017)Toll-like receptors (TLR)s are innate immune receptors for microbial molecules and also sense damage-associated molecular patterns released from host cells. Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic ... -
The Metastatic Intestinal Epithelial cell line SW620 produce neutrophil-attracting chemokines and extracellular matrix associated components in a Toll-Like Receptor 3 dependent manner
Skauge, Nadia Huse (Master thesis, 2020)Toll-lik reseptor 3 (TLR) er en mønstergjenkjennende reseptor (PRR) som kan indusere immunresponser når de gjenkjenner dsRNA, endogent mRNA oog den syntetiske TLR3 liganden Poly(I:C). Tiidligere har den metastatiske ... -
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells
Bugge, Marit (Doctoral thesis at NTNU;2016:77, Doctoral thesis, 2016)Toll-lignende reseptor 3 uttrykk og signalisering i kolonepitelceller: Toll-lignende reseptorer (TLRer) er viktige sensorer i menneskets medfødte immunforsvar og aktiveres av komponenter som representerer fare for verten, ...