Blar i NTNU Open på forfatter "Brunelli, Cinzia"
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A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Almberg, Sigrun Saur; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Thronæs, Morten; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2017)Purpose The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the ... -
A prospective study examining cachexia predictors in patients with incurable cancer
Vagnildhaug, Ola Magne; Brunelli, Cinzia; Hjermstad, Marianne Jensen; Strasser, Florian; Baracos, Vickie; Wilcock, Andrew; Nabal, María; Kaasa, Stein; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based ... -
An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay
Løhre, Erik Torbjørn; Thronæs, Morten; Brunelli, Cinzia; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ... -
Cancer pain assessment, classification and patient reported outcomes in the evaluation of treatment effect
Brunelli, Cinzia (Doctoral theses at NTNU;2016:328, Doctoral thesis, 2016)Pain is common in patients with cancer and it has a strong impact on quality of life. Despite the development of guidelines, cancer pain treatment is suboptimal. This is often due to lack of efficient, standardized and ... -
Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases
Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Gunnhild; Abramova, Tatiana Mikhailovna; Garcia-Alonso, Elena; Caputo, Mariangela; Rossi, Romina; Boland, Jason W.; Brunelli, Cinzia; Lund, Jo-Åsmund; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful ... -
Development of EirV3 - a computer-based tool for patient reported outcome measures in cancer
Krogstad, Hilde; Brunelli, Cinzia; Sand, Kari; Andersen, Eivind; Garresori, Herish; Halvorsen, Tarje Onsøien; Haukland, Ellinor Christin; Jordal, Frode; Kaasa, Stein; Loge, Jon Håvard; Løhre, Erik Torbjørn; Raj, Sunil Xavier; Hjermstad, Marianne Jensen (Journal article; Peer reviewed, 2017)Purpose Immediate transfer of patient-reported outcome measures (PROMs) for use in medical consultations is facilitated by electronic assessments. We aimed to describe the rationale and development of Eir version 3 (EirV3), ... -
Do laws impact opioids consumption? A breakpoint analysis based on italian sales data
Musazzi, Umberto Maria; Rocco, Paolo; Brunelli, Cinzia; Bisaglia, Luisa; Caraceni, Augusto Tomasso Giovanni; Minghetti, Paola (Journal article; Peer reviewed, 2018)Purpose: In Italy, where the adoption of opioid analgesics in pain management has been historically poor, an increase in opioids consumption occurred between 2000 and 2015. The aim of this study is to assess, through ... -
From "breakthrough" to "episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations
Løhre, Erik T; Klepstad, Pål; Bennett, Michael I.; Brunelli, Cinzia; Caraceni, Augusto; Fainsinger, Robin L.; Knudsen, Anne Kari; Mercadante, Sebastiano; Sjøgren, Per; Kaasa, Stein (Journal article; Peer reviewed, 2016)Context Cancer pain can appear with spikes of higher intensity. Breakthrough cancer pain (BTCP) is the most common term for the transient exacerbations of pain, but the ability of the nomenclature to capture relevant ... -
Fully Integrated Oncology and Palliative Care Services at a Local Hospital in Mid-Norway: Development and Operation of an Innovative Care Delivery Model
Brenne, Anne-Tove; Knudsen, Anne Kari; Raj, Sunil Xavier; Skjelvan, Laila Strand; Lund, Jo-Åsmund; Thronæs, Morten; Løhre, Erik Torbjørn; Hågensen, Liv Ågot; Brunelli, Cinzia; Kaasa, Stein (Peer reviewed; Journal article, 2020)Introduction Early access to cancer palliative care is recommended. Descriptions of structures and processes of outpatient palliative care clinics operated within smaller hospitals are scarce. This paper presents the ... -
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients
Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tomasso Giovanni (Peer reviewed; Journal article, 2020)Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ... -
Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia; Rossi, Romina; Garcia-Alonso, Elena; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2022)Context Inflammation is proposed to influence tumor response in radiotherapy (RT). Clinical studies to investigate the relationship between inflammatory markers and RT response is warranted to understand the variable RT ... -
Is it possible to detect an improvement in cancer pain management? A comparison of two Norwegian cross-sectional studies conducted 5 years apart.
Thronæs, Morten; Raj, Sunil; Brunelli, Cinzia; Almberg, Sigrun Saur; Vagnildhaug, Ola Magne; Bruheim, Susanna; Helgheim, Birgit; Kaasa, Stein; Knudsen, Anne Kari (Journal article; Peer reviewed, 2016)Purpose: Cancer pain (CP) management is challenging. In recent years, efforts were undertaken to achieve better CP management, e.g. clinical research, new treatment modalities, development of guidelines, education, and ... -
Pain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Study
Løhre, Erik Torbjørn; Hjermstad, Marianne Jensen; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2018)Introduction Different definitions of breakthrough pain (BTP) influence the observed BTP prevalence. This study examined BTP prevalence variability due to use of different cutoffs for controlled background pain, different ... -
Pain management index (PMI)-does it reflect cancer patients? wish for focus on pain?
Thronæs, Morten; Balstad, Trude Rakel; Brunelli, Cinzia; Løhre, Erik Torbjørn; Klepstad, Pål; Vagnildhaug, Ola Magne; Kaasa, Stein; Knudsen, Anne Kari; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background The pain management index (PMI) was developed to combine information about the prescribed analgesics and the self-reported pain intensity in order to assess physicians’ response to patients’ pain. However, ... -
PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care
Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Andersen, Sigve; Brunelli, Cinzia; Dajani, Olav; Ahmed, Herish; Hamre, Hanne Mari; Haukland, Ellinor Christin; Holmberg, Mats; Jordal, Frode; Krogstad, Hilde; Lundeby, Tonje; Løhre, Erik T; Mjåland, Svein; Nordbø, Arve; Paulsen, Ørnulf; Staff, Erik Schistad; Wester, Torunn; Kaasa, Stein; Loge, Jon Håvard (Peer reviewed; Journal article, 2020)Background - Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in ... -
Power comparisons and clinical meaning of outcome measures in assessing treatment effect in cancer cachexia: secondary analysis from a randomised pilot multimodal intervention trial
Balstad, Trude Rakel; Brunelli, Cinzia; Pettersen, Caroline Hild; Schønberg, Svanhild Margrethe Arentz; Skorpen, Frank; Fallon, Marie T.; Kaasa, Stein; Bye, Asta; Laird, Barry J. A.; Stene, Guro Birgitte; Solheim, Tora Skeidsvoll (Peer reviewed; Journal article, 2020)Background: New clinical trials in cancer cachexia are essential and outcome measures with high responsiveness to detect meaningful changes are crucial. This secondary analysis from a multimodal intervention trial estimates ... -
Spiritual quality of life in family carers of patients with advanced cancer—a cross-sectional study
Røen, Ingebrigt; Brenne, Anne-Tove; Brunelli, Cinzia; Grande, Gunn; Stifoss-Hanssen, Hans; Solheim, Tora Skeidsvoll; Kaasa, Stein; Knudsen, Anne Kari (Peer reviewed; Journal article, 2021)Purpose Caring affects carers’ psychological and physical health, mortality, and quality of life (QoL) negatively. Lower spiritual QoL is associated with anxiety and depression, but the spiritual dimension is rarely ... -
Standardizing Integrated Oncology and Palliative Care Across Service Levels: Challenges in Demonstrating Effects in a Prospective Controlled Intervention Trial
Brenne, Anne Tove; Løhre, Erik Torbjørn; Knudsen, Anne Kari; Lund, Jo-Åsmund; Thronæs, Morten; Driller, Bardo; Brunelli, Cinzia; Kaasa, Stein (Journal article; Peer reviewed, 2024)Introduction: Patients with cancer often want to spend their final days at home. In Norway, most patients with cancer die in institutions. We hypothesized that full integration of oncology and palliative care services would ... -
The Palliative Radiotherapy and Inflammation Study (PRAIS) - Protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain 11 Medical and Health Sciences 1103 Clinical Sciences
Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Abramova, Tatiana Mikhailovna; Baas, Theo; Mørkeset, Siri Tessem; Caraceni, Augusto; Laird, Barry J; Boland, Jason W.; Rossi, Romina; Garcia-Alonso, Elena; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Bjerkeset, Ellen; Bye, Asta; Lund, Jo-Åsmund; Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Brunelli, Cinzia; Damås, Jan Kristian; Mollnes, Tom Eirik; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2018)Background Radiation therapy (RT) results in pain relief for about 6 of 10 patients with cancer induced bone pain (CIBP) caused by bone metastases. The high number of non-responders, the long median time from RT to pain ... -
Which factors can aid clinicians to identify a risk of pain during the following month in patients with bone metastases? A longitudinal analyses
Habberstad, Ragnhild H; Hjermstad, Marianne Jensen; Brunelli, Cinzia; Kaasa, Stein; Bennett, Michael I; Pardon, Koen; Klepstad, Pål (Journal article; Peer reviewed, 2018)Purpose Explore clinical factors associated with higher pain intensity and future pain in patients with bone metastases to identify patients who can benefit from closer follow-up or pain-modifying interventions. Methods This ...