• Chemoenzymatic Synthesis of Synthons as Percursors for Enantiopure Clenbuterol and Other β2-Agonists 

      Blindheim, Fredrik Heen; Hansen, Mari Bergan; Evjen, Sigvart; Zhu, Wei; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2018)
      Clenbuterol is a β2-agonist used in the veterinary treatment of asthma in several countries. The drug is listed on the World Antidoping Agency’s prohibited list due to its effect on increased protein synthesis in the body. ...
    • Synthesis of Enantiopure Precursors for Clenbuterol 

      Blindheim, Fredrik Heen (Master thesis, 2017)
      The primary goal of this thesis was to synthesize enantiopure (R)-clenbuterol and its precursors by using enzymes as chiral catalysts. As a secondary goal, the substrate acceptance of ketoreductase 228 (KRED 228) was ...
    • Synthesis of Thymidylate Kinase Inhibitor Precursors 

      Haugen, Thomas Wean (Master thesis, 2019)
      Multimedikamentresistente bakterier er en av de største helseutfordringene verden står oven- for i dag, noe som gjør forskning og utvikling av ny antibiotika viktigere enn noen sinne. Hemming av et av nøkkelenzymene i ...