Browsing NTNU Open by Author "Austdal, Marie"
Now showing items 1-13 of 13
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Biomarkers for prediction and characterization of preeclampsia using magnetic resonance metabolomics
Austdal, Marie (Doctoral thesis at NTNU;2015:230, Doctoral thesis, 2015) -
Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia
Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ... -
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction
Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2022)Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ... -
First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study
Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article; Peer reviewed, 2015)Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019)Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
New immune phenotypes for treatment response in high-grade serous ovarian carcinoma patients
Torkildsen, Cecilie Fredvik; Austdal, Marie; Jarmund, Anders Hagen; Kleinmanns, Katrin; Lamark, Eva Karin; Nilsen, Elisabeth Berge; Stefansson, Ingunn Marie; Sande, Ragnar; Iversen, Ann-Charlotte; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line (Journal article; Peer reviewed, 2024)Despite advances in surgical and therapeutic approaches, high-grade serous ovarian carcinoma (HGSOC) prognosis remains poor. Surgery is an indispensable component of therapeutic protocols, as removal of all visible tumor ... -
Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins
Torkildsen, Cecilie Fredvik; Austdal, Marie; Iversen, Ann-Charlotte; Bathen, Tone Frost; Giskeødegård, Guro F.; Nilsen, Elisabeth Berge; Iversen, Grete Alræk; Sande, Ragnar; Bjørge, Line; Thomsen, Liv Cecilie Vestrheim (Peer reviewed; Journal article, 2023)High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ... -
Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts
Gierman, Lobke; Stødle, Guro; Tangerås, Line Haugstad; Austdal, Marie; Olsen, Guro Dalheim; Follestad, Turid; Skei, Bente; Rian, Kristin; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Introduction Excessive placental inflammation is associated with pregnancy complications. Toll-like receptors (TLRs) are sensors for danger signals from infections and damaged tissue and initiate inflammation. Trophoblasts ...