Blar i NTNU Open på forfatter "Astrup, Elisabeth"
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A Complex Interaction between Rickettsia conorii and Dickkopf-1 - Potential Role in Immune Evasion Mechanisms in Endothelial Cells
Astrup, Elisabeth; Lekva, Tove; Davi, Giovanni; Otterdal, Kari; Santilli, Francesca; Øie, Erik; Halvorsen, Bente; Damås, Jan Kristian; Raoult, Didier; Vitale, Giustina; Olano, Juan P; Ueland, Thor; Aukrust, Pål (Journal article; Peer reviewed, 2012)The pathophysiological hallmark of spotted fever group rickettsioses comprises vascular inflammation. Based on the emerging importance of the wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized ... -
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome
Damås, Jan Kristian; Otterdal, Kari; Astrup, Elisabeth; Lekva, Tove; Janardhanan, Jeshina; Michelsen, Annika Elisabet; Aukrust, Pål; Varghese, George M.; Ueland, Thor (Journal article; Peer reviewed, 2024)Purpose: The mechanisms that control inflammation in scrub typhus are not fully elucidated. The Notch pathways are important regulators of inflammation and infection, but have not been investigated in scrub typhus. Methods: ... -
Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality
Astrup, Elisabeth; Janardhanan, J; Otterdal, Kari; Ueland, Thor; Prakash, JAJ; Lekva, Tove; Strand, Øystein Anders; Abraham, OC; Thomas, K; Damås, Jan Kristian; Mathews, P; Mathai, D; Aukrust, Pål; Varghese, GM (Journal article; Peer reviewed, 2014)Background: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10–20%, further knowledge of the immune response during ... -
The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017
Elstrøm, Petter; Astrup, Elisabeth; Hegstad, Kristin; Samuelsen, Ørjan; Enger, Hege; Kacelnik, Oliver (Peer reviewed; Journal article, 2019)Introduction: Scandinavian countries have traditionally had a low prevalence of resistant organisms, but have in recent years experienced a change in their epidemiology. We aim to describe the epidemiology of carbapenema ... -
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
Astrup, Elisabeth; Ranheim, Trine; Damås, Jan Kristian; Davi, Giovanni; Santilli, Francesca; Jensenius, Mogens; Vitale, Giustina; Aukrust, Pål; Olano, Juan P; Otterdal, Kari (Journal article; Peer reviewed, 2014)Background: Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Methods: ... -
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Otterdal, Kari; Portillo, Aránzazu; Astrup, Elisabeth; Ludviksen, Judith K; Schjalm, Camilla; Raoult, Didier; Olano, Juan Pablo; Halvorsen, Bente; Oteo Revuelta, José Antonio; Aukrust, Pål; Mollnes, Tom Eirik; Nilsson, Per (Journal article, 2016)Mediterranean spotted fever caused by Rickettsia conorii is a potentially lethal disease characterized by vascular inflammation affecting multiple organs. Studies of R. conorii so far have focused on activation of inflammatory ... -
Secreted wnt antagonists in scrub typhus
Ueland, Thor; Astrup, Elisabeth; Otterdal, Kari; Lekva, Tove; Janardhanan, Jeshina; Prakash, John A.; Thomas, Kurien; Michelsen, Annika; Aukrust, Pål; Varghese, George M.; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)Background The mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. The wingless (Wnt) signaling pathways are emerging as important regulators of inflammation and ...