• Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls 

      Aulie, Hanne Aaserud; Estensen, Mette-Elise; Selvaag, AM; Lilleby, Vibeke; Flatø, Berit; Aakhus, Svend (Journal article; Peer reviewed, 2018)
      Background The data on cardiovascular risk and systemic arterial properties in patients with long-lasting juvenile idiopathic arthritis (JIA) is limited. The objective of this study was to describe systemic arterial ...
    • Combining Automatic Angle Correction and 3-D Tracking Doppler for the Assessment of Aortic Stenosis Severity 

      Fiorentini, Stefano; Espeland, Torvald; Berg, Erik Andreas Rye; Aakhus, Svend; Torp, Hans; Avdal, Jørgen (Journal article; Peer reviewed, 2019)
      Aortic valve stenosis (AS) is a narrowing of the aortic valve opening, which causes increased load on the left ventricle. Untreated, this condition can eventually lead to heart failure and death. According to current ...
    • Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial 

      Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune; Gullestad, Lars (Journal article; Peer reviewed, 2016)
      Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ...
    • Eliciting Patient Risk Willingness in Clinical Consultations as a Means of Improving Decision-Making of Aortic Valve Replacement 

      Hussain, Amjad; Garratt, Andrew; Brunborg, Cathrine; Aakhus, Svend; Gullestad, Lars; Pettersen, Kjell I (Journal article; Peer reviewed, 2016)
      Background: Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. Methods and Results: We assessed ...
    • Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis 

      Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K; Hussain, Amjad Iqbal; Pettersen, Kjell; Aakhus, Svend; Espeland, Torvald; Lunde, Ida Gjervold; Kirschfink, Michael; Nilsson, Per; Mollnes, Tom Eirik; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2019)
      Inflammation is involved in initiation and progression of aortic stenosis (AS). However, the role of the complement system, a crucial component of innate immunity in AS, is unclear. We hypothesized that circulating levels ...
    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2018)
      Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ...
    • Left ventricular diastolic dysfunction predicts mortality in patients with systemic sclerosis 

      Tennøe, Anders; Murbræch, Klaus; Andreassen, Johanna; Fretheim, Håvard Halland; Garen, Torhild Oddveig; Gude, Einar; Andreassen, Arne K.; Aakhus, Svend; Molberg, Øyvind; Hoffmann-Vold, Anna-Maria (Journal article; Peer reviewed, 2018)
      Background Primary cardiac affection is common and is a major cause of death in systemic sclerosis (SSc), but there are knowledge gaps regarding the effect of cardiac dysfunction on mortality. Objectives The purpose ...
    • Myokardfibrose 

      Espeland, Torvald; Lunde, Ida Gjervold; Amundsen, Brage H.; Gullestad, Lars; Aakhus, Svend (Journal article; Peer reviewed, 2018)
      BAKGRUNN Myokardfibrose oppstår sekundært til kardial belastning eller skade. I denne oversiktsartikkelen presenteres sentrale aspekter ved myokardfibrose. KUNNSKAPSGRUNNLAG Vi foretok 2 søk i PubMed som til sammen ...
    • Predictors of early mortality after transcatheter aortic valve implantation 

      Kjønås, Didrik; Dahle, Gry; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Rösner, Assami (Journal article; Peer reviewed, 2019)
      Objectives To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the ...
    • Prevalence, risk factors, and type of sleep apnea in patients with paroxysmal atrial fibrillation 

      Traaen, Gunn Marit; Øverland, Britt; Aakerøy, Lars; Hunt, Tove Elizabeth Frances; Bendz, Christina; Leif Magne, Sande; Aakhus, Svend; Zare, Hasse Khiabani; Steinshamn, Sigurd Loe; Anfinsen, Ole-Gunnar; Loennechen, Jan Pål; Gullestad, Lars; Akre, Harriet (Peer reviewed; Journal article, 2019)
      Background Recent studies have suggested an association between sleep apnea (SA) and atrial fibrillation (AF). We aimed to study the prevalence, characteristics, risk factors and type of sleep apnea (SA) in ablation ...
    • Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI). 

      Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Broch, Kaspar; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Hopp, Einar; Kleveland, Ola; STENSÆTH, KNUT HAAKON; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål; Gullestad, Lars (Journal article; Peer reviewed, 2019)
      Introduction Interleukin-6 (IL-6) may be involved in ischaemia-reperfusion injury and myocardial remodelling after myocardial infarction (MI). We have recently shown that IL-6 inhibition by tocilizumab attenuates systemic ...
    • Systolic dysfunction in systemic sclerosis: Prevalence and prognostic implications 

      Tennøe, Anders H; Murbraech, Klaus; Andreassen, Johanna; Fretheim, Håvard Halland; Midtvedt, Øyvind; Garen, Torhild Oddveig; Dalen, Håvard; Gude, Einar; Andreassen, Arne K.; Aakhus, Svend; Molberg, Øyvind; Hoffmann-Vold, Anna-Maria (Journal article, 2019)
      Objective Primary cardiac involvement is presumed to account for a substantial part of disease‐related mortality in systemic sclerosis (SSc). Still, there are knowledge gaps on the evolution and total burden of systolic ...
    • Treatment of sleep apnea in patients with paroxysmal atrial fibrillation: design and rationale of a randomized controlled trial 

      Traaen, Gunn Marit; Aakerøy, Lars; Hunt, Tove Elisabeth F.; Øverland, Britt; Lyseggen, Erik; Aukrust, Pål; Ueland, Thor; Helle-Valle, Thomas Michael; Steinshamn, Sigurd Loe; Edvardsen, Thor; Zare, Hasse Khiabani; Aakhus, Svend; Akre, Harriet; Anfinsen, Ole-Gunnar; Loennechen, Jan Pål; Gullestad, Lars (Journal article; Peer reviewed, 2018)
      Rationale. Atrial fibrillation is associated with increased mortality as well as morbidity. There is strong evidence for an association between atrial fibrillation and sleep apnea. It is not known whether treatment of sleep ...
    • Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy 

      Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar; Ueland, Thor (Journal article; Peer reviewed, 2017)
      The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in ...